Vascular adaptive responses to physical exercise and to stress are affected differently by nandrolone administration

Bruder‐Nascimento, Thiago; Cordellini, Sandra

doi:10.1590/s0100-879x2011007500043

Cited by 14 publications

(18 citation statements)

References 36 publications

(34 reference statements)

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“…In humans, stress affects feeding of two ways; in one group, about 30%, food intake is decreased, and consequently there is loss of body weight during or after of stressful situation, whereas most people increase food intake during exposure to stress (19,20). Several studies has used hypercaloric or high-fat diet based on unsaturated fatty acid to analyze obesity (11,17). The present study is in agreement with previous studies (21,22), which show that high-fat diet increases the adiposity index.…”

Section: Discussionmentioning

confidence: 99%

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Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

Bruder‐Nascimento

Campos

Alves

et al. 2013

Arq Bras Endocrinol Metab

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Objective: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. Materials and methods: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. Results: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. Conclusion: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet. Arq Bras Endocrinol Metab. 2013;57(8):642-9 Keywords Chronic stress; high-fat diet; calorie intake and food intake RESUMO Objetivo: Avaliar o papel do estresse crônico sobre parâmetros metabólicos e nutricionais de ratos expostos à dieta rica em gordura. Materiais e métodos: Ratos Wistar machos (30 dias de idade/70-100 g) foram distribuídos em quatro grupos: dieta-normal (NC), estresse crônico (St), dieta rica em gordura (HD) e estresse crônico/dieta rica em gordura (HD/St). O estresse consistiu em imobilização durante 15 semanas, 5 vezes por semana 1h por dia e a dieta rica em gordura foi oferecida por 15 semanas. Parâmetros nutricionais e metabólicos foram avaliados. O nível de significância foi de 5%. Resultados: HD tiveram peso corpóreo, gordura total e níveis de insulina e leptina aumentados e foram resistentes à insulina. Os grupos St e HD/St manifestaram hipertensão e níveis séricos de corticosterona elevados. O estresse bloqueou os efeitos da dieta. Conclusão: O estresse impediu o surgimento dela. Nossos resultados ajudam compreender os mecanismos envolvidos na disfunção metabólica e nutricional e contribuem para casos clínicos de estresse e dietas ricas em gorduras. Arq Bras Endocrinol Metab. 2013;57(8):642-9 Descritores Estresse crônico; dieta rica em gordura; consumo calórico e metabolismo

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Section: Discussionmentioning

confidence: 99%

“…Stress is linked to several diseases and dysfunctions, such as cardiovascular alterations, immunologic function disorders, asthma, allergy, ulcer, depression, chronic anxiety, insulin resistance, overweight, and obesity (6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

Bruder‐Nascimento

Campos

Alves

et al. 2013

Arq Bras Endocrinol Metab

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“…This increase of corticosterone is associated with adrenal glands hypertrophy. Various investigators have used the fresh weight of the adrenal gland, an organ that responds to stress, as indicative of stressogenic conditions 8 . The weight of the adrenal gland may be reduced or may remain unchanged after exposure to acute stress, but is often increased by chronic stress 24,25 .…”

Section: Discussionmentioning

confidence: 99%

“…The most well-defined cardiovascular disorders related to chronic stress in humans are arterial hypertension, heart rate variability, left ventricular systolic and diastolic dysfunction and vascular alterations [5][6][7][8] . In addition, this variable stress for 15 days was able to produce hypertrophic cardiac and permanent cardiac structural changes 9 .…”

Section: Introductionmentioning

confidence: 99%

Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos

Bruder‐Nascimento

Campos

Leopoldo

et al. 2012

Arq. Bras. Cardiol.

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“…It was also reported that chronic administration of nandrolone and swimming exercise, alone or in combination, have no effect on BP (29,45). However, previous studies showed that in hypertensive mice, endurance exercise could significantly reduce BP (46,47).…”

Section: Discussionmentioning

confidence: 99%

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

Joukar¹,

Baravati²,

Fathpour³

et al. 2015

Res Cardiovasc Med

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Background: Until now, no experimental study has directly assessed the arrhythmogenesis of chronic consumption of anabolic androgenic steroids along with moderate-intensity endurance exercise. Objectives: We evaluated the influence of integration of anabolic androgenic steroids along with moderate-intensity endurance exercise on susceptibility to lethal ventricular arrhythmias in rat. Materials and Methods:The animal groups were as follows: control group (CTL); exercise group (EX) which were under 6 weeks of treadmill exercise; nandrolone group (Nan) which received 5 mg/kg of nandrolone decanoate twice a week; vehicle group (Arach) which received Arachis oil (solvent of nandrolone); trained vehicle group (Arach + Ex); and trained nandrolone group (Nan + Ex). One day after ending of the intervention period, arrhythmia was inducted by intravenous infusion of aconitine and ventricular arrhythmias were recorded. Then malondialdehyde (MDA) and glutathione peroxidase (GPX) of heart tissue were measured. Results: Nandrolone, exercise, and their combination were associated with heart hypertrophy. Exercise could prevent the incremental effect of nandrolone on MDA/GPX ratio. Chronic administration of nandrolone with moderate-intensity endurance exercise had no significant effect on blood pressure, heart rate, and basal electrocardiographic parameters. Combination of nandrolone and exercise significantly increased the incidence of ventricular fibrillation (VF) and reduced the VF latency (P < 0.05). Conclusions:The findings suggest that chronic coadministration of nandrolone with moderate-intensity endurance exercise facilitates the VF occurrence in rat. Complementary studies are needed to elucidate the involved mechanisms of this abnormality.

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Vascular adaptive responses to physical exercise and to stress are affected differently by nandrolone administration

Cited by 14 publications

References 36 publications

Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos

Nandrolone plus moderate exercise increases the susceptibility to lethal arrhythmias

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