Leptin and adiponectin in the female life course

Lecke, Sheila Bünecker; Morsch, Débora Martinho; Spritzer, Poli Mara

doi:10.1590/s0100-879x2011007500035

Cited by 21 publications

(19 citation statements)

References 88 publications

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“…However, Thurston et al found that the association of adipokines with hot flashes was marginally significant and varied by menopausal stage [16]. Accumulated evidence indicates that estrogen is an important shared risk factor relevant to hot flashes and adipocyte-derived hormones [15,16,20]. For instance, leptin concentrations vary with the level of sex hormones, particularly estrogen in ovulatory women [21,22].…”

Section: Discussionmentioning

confidence: 99%

Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

et al. 2017

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IntroductionHot flashes have been postulated to be linked to the development of metabolic disorders. This study aimed to evaluate the relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women.Participants and designIn this cross-sectional study, a total of 151 women aged 45–60 years were stratified into one of three groups according to hot-flash status over the past three months: never experienced hot flashes (Group N), mild-to-moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, fasting levels of circulating glucose, lipid profiles, plasma insulin, and adipocyte-derived hormones. Multiple linear regression analysis was used to evaluate the associations of hot flashes with adipocyte-derived hormones, and with insulin resistance.SettingsThe study was performed in a hospital medical center.ResultsThe mean (standard deviation) of body-mass index was 22.8(2.7) for Group N, 22.6(2.6) for Group M, and 23.5(2.4) for Group S, respectively. Women in Group S displayed statistically significantly higher levels of leptin, fasting glucose, and insulin, and lower levels of adiponectin than those in Groups M and N. Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with higher leptin levels, lower adiponectin levels, and higher leptin-to-adiponectin ratio. Univariate linear regression analysis revealed that hot-flash severity was strongly associated with a higher HOMA-IR index (% difference, 58.03%; 95% confidence interval, 31.00–90.64; p < 0.001). The association between hot flashes and HOMA-IR index was attenuated after adjusting for leptin or adiponectin and was no longer significant after simultaneously adjusting for leptin and adiponectin.ConclusionThe present study provides evidence that hot flashes are associated with insulin resistance in postmenopausal women. It further suggests that hot flash association with insulin resistance is dependent on the combination of leptin and adiponectin variables.

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Section: Discussionmentioning

confidence: 99%

Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

et al. 2017

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“…Functional analysis CCL15 was performed with murine HPCs, in order to build the basis for further investigations in different stem cell transplantation and regenerative medicine models with non-immunocompromised mice [15,16,17]. There are a number of facts indicating that mouse models are sufficient to perform an initial preclinical evaluation of CCL15.…”

Section: Discussionmentioning

confidence: 99%

“…The impact of CCL15 was investigated in murine HPCs, building the basis for further investigation in different stem cell transplantation and regenerative medicine models with non-immunocompromised mice [15,16,17]. The N-terminally truncated form of CCL15 acts on HPCs by amplifying CXCL12-induced transwell migration and directly inducing integrin-mediated adhesion.…”

Section: Introductionmentioning

confidence: 99%

Beta-Chemokine CCL15 Affects the Adhesion and Migration of Hematopoietic Progenitor Cells

Richter

Rüster

Bistrian

et al. 2014

Transfus Med Hemother

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Background: Hematopoietic stem and progenitor cell (HPC) motility is essential for HPC transplantation. The chemokine CXCL12 is key for HPC motility. Further regulators are of interest to improve HPC transplantation and regenerative medicine. Here the impact of the human chemokine CCL15 on HPC motility was investigated. Methods: CCL15 plasma concentrations were determined during HPC mobilization in humans. Activity of CCL15 on HPCs was investigated in murine assays, including chemotaxis, adhesion, and CFU-A assays, and competitive repopulation assays. Results: During HPC mobilization with granulocyte colony-stimulating factor, blood plasma contains increased concentrations (1.1 ± 0.1 ng/ml) of activated CCL15(27-92) versus 0.4 ± 0.1 ng/ml in controls (p = 0.02). CCL15(27-92) significantly enhanced CXCL12-induced transwell migration of Lin-/Sca1+ HPCs and strengthened shear stress-dependent adhesion to vascular cell adhesion molecule-1 (VCAM-1). CCL15(27-92) dose-dependently reduced the colony size in CFU-A assays performed with murine bone marrow and Lin-/Sca1+ HPCs. CCL15(27-92) did not show a direct impact on cell cycle status of HPCs. In murine repopulation assays, pretreatment of bone marrow with CCL15(27-92) significantly increased competitive repopulation. Conclusion: Our results point to a regulation of HPCs by CCL15 by modulating migratory and adhesive properties of HPCs with the potency to improve HPC short-term engraftment in stem cell transplantation.

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“…These findings are not well understood so far and the results in adults are conflicting [19][20][21][22]. Adiponectin concentrations in life course are complex and change over time in females [23]. Between the age of 5 and 8 years, adiponectin concentrations decrease independent of BMI.…”

Section: Tablementioning

confidence: 99%

Cord blood n-3 LC-PUFA is associated with adiponectin concentrations at 10 years of age

Standl

Demmelmair²,

Koletzko³

et al. 2015

Prostaglandins, Leukotrienes and Essential Fatty Acids

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An elevated ratio of n-6 to n-3 long-chain (LC-) polyunsaturated fatty acids (PUFA) may be a potential risk factor for obesity development. N-3 LC-PUFA are thought to alter adiponectin concentrations, and thus may have a beneficial effect on weight development. We analysed the association between n-3 LC-PUFA concentrations in cord blood and adiponectin concentrations at 10 years. Fatty acid composition was measured in cord blood and at 10 years of age by gas chromatography, and adiponectin concentrations were measured only at 10 years of age in 237 children from the Munich LISAplus birth cohort study. Linear regression models assessed associations between n-3 LC-PUFA, n-6 LC-PUFA and the n-6/n-3 ratio in cord blood with adiponectin concentrations at 10 years of age. LC-PUFA were presented as percentages and categorized into tertiles. Regression models were adjusted for LC-PUFA percentages at 10 years of age and other potential confounding factors. Cord blood n-3 LC-PUFA tertiles were significantly associated with adiponectin concentrations in an inverse J-shaped relationship [2nd tertile versus 1st tertile: Beta=1.84 (SE=0.65), and 3rd tertile versus 1st tertile: 1.02 (0.68), p-value<0.01 (ANOVA)]. Further, cord blood n-6/n-3 ratios were significantly associated with adiponectin concentrations [2nd tertile versus 1st tertile: 0.14 (0.67), and 3rd tertile versus 1st tertile: -1.37 (0.68), p-value=0.03 (ANOVA)]. The cord blood n-6 LC-PUFA tertiles were not associated with adiponectin concentrations. Our results suggest that a higher n-3 LC-PUFA concentrations and a lower n-6/n-3 ratio in cord blood are associated with higher adiponectin concentrations at 10 years of age.

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Leptin and adiponectin in the female life course

Cited by 21 publications

References 88 publications

Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

Beta-Chemokine CCL15 Affects the Adhesion and Migration of Hematopoietic Progenitor Cells

Cord blood n-3 LC-PUFA is associated with adiponectin concentrations at 10 years of age

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