5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus

Gualda, L B; Martins, Gabriel G.; Müller, Bianca; Guimarães, F.S.; Oliveira, Rúbia Maria Weffort de

doi:10.1590/s0100-879x2011007500033

Cited by 16 publications

(5 citation statements)

References 20 publications

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“…In addition to this trophic effect, CGRP is known to increase the synthesis of acetylcholine receptors at the level of the neuromuscular junction (New and Mudge, ). The presence of CGRP in cell bodies located in the raphae nuclei suggests that the neuropeptide could regulate the activity of spinal motor nuclei, as suggested previously (Arvidsson et al, ; Gualda et al, ).…”

Section: Discussionsupporting

confidence: 73%

Distribution of CGRP in the minipig brainstem

Sánchez

Vecino

Coveñas

2014

Microscopy Res & Technique

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For the first time, an in-depth study has been made of the distribution of fibers and cell bodies containing calcitonin gene-related peptide (CGRP) in the minipig brainstem using an indirect immunoperoxidase technique. The animals studied were not treated with colchicine. Cell bodies containing CGRP were found in 20 nuclei/regions of the brainstem. These perikarya were located in somatomotor, brachiomotor and raphae nuclei, nucleus ambiguus, substantia nigra, nucleus reticularis tegmenti pontis, nucleus prepositus hypoglossi, nuclei olivaris inferior and superior, nuclei pontis, formatio reticularis, nucleus dorsalis tegmenti of Gudden, and in the nucleus reticularis lateralis. Fourteen of the 20 brainstem nuclei showed a high density of immunoreactive cell bodies. In comparison with other species, the minipig, together with the rat, show the most widespread distribution of cell bodies containing CGRP in the mammalian brainstem. Immunoreactive fibers were also observed in the brainstem. However, in the minipig brainstem the density of these fibers is low, as in many brainstem nuclei only single immunoreactive fibers were observed. A high density of immunoreactive fibers was only observed in the pars caudalis of the nucleus tractus spinalis nervi trigemini and in the nucleus ventralis tegmenti of Gudden. According to the observed anatomical distribution of the immunoreactive structures containing CGRP, the peptide could be involved in motor, somatosensory, gustative, and autonomic mechanisms.

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Section: Discussionsupporting

confidence: 73%

Distribution of CGRP in the minipig brainstem

Sánchez

Vecino

Coveñas

2014

Microscopy Res & Technique

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“…In rodents, this has a biphasic effect on locomotion where high concentrations of 7‐NI increases locomotion and low concentrations decreases it (Spiacci, Kanamaru, Guimarães, & Oliveira, ). Another study demonstrated that pretreatment with 5‐HT1a receptor agonist, 8‐OH‐DPAT, blocked the increase in locomotor activity induced by the microinjection of peroxynitrite donors in the raphe nucleus (Gualda, Martins, Müller, Guimarães, & Oliveira, ). Whether stage development switching of nitrergic and aminergic signalling in spinal locomotor networks alters the relationship between these neuromodulatory systems is an interesting and important avenue that has yet to be explored.…”

Section: Key Neuromodulators Of Developing Locomotor Networkmentioning

confidence: 99%

Developmental stage‐dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks

Hachoumi

Sillar

2019

Developmental Neurobiology

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Neuromodulation plays important and stage‐dependent roles in regulating locomotor central pattern (CPG) outputs during vertebrate motor system development. Dopamine, serotonin and nitric oxide are three neuromodulators that potently influence CPG outputs in the development of Xenopus frog tadpole locomotion. However, their roles switch from predominantly inhibitory early in development to mainly excitatory at later stages. In this review, we compare the stage‐dependent switching in neuromodulation in Xenopus with other vertebrate systems, notably the mouse and the zebrafish, and highlight features that appear to be phylogenetically conserved.

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“…For example, nNOS-derived NO has been reported to induce antidepressant and anxiolytic effects [48][49][50]. In addition, the effects of NO on locomotor activity in the dorsal raphe nucleus is mediated through the 5HT 1A receptors [51].…”

Section: Discussionmentioning

confidence: 99%