The methyl ester of rosuvastatin elicited an endothelium-independent and 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent relaxant effect in rat aorta

Pharmacological characterization of mechanisms involved in the vasorelaxation produced by rosuvastatin in aortic rings from rats with a cafeteria‐style diet

“…Phenylephrine enhanced the vasorelaxant response produced by rosuvastatin (E max 59.88 ± 6.85% of the phenylephrine‐induced contraction), making the vasorelaxant effect produced by rosuvastatin more evident. This result is in accordance with previous reports on in vitro studies that employed other drugs with a vasorelaxant effect . Precontraction with phenylephrine also makes the effects produced by antagonists and blockers more evident.…”

“…The fact that 10 −5 ‐mol/L cycloheximide, a general protein synthesis inhibitor, significantly attenuated ( P < 0.05) the vasorelaxant effect produced by rosuvastatin in aortic rings from rats with a CAF diet suggests the involvement of protein synthesis in this vasorelaxation. This suggestion is consistent with previous findings in which 10 −5 ‐mol/L cycloheximide inhibited the vasorelaxant response produced by the methyl ester of rosuvastatin . Nevertheless, it must be taken into account that cycloheximide also facilitates the induction of cellular apoptosis .…”

“…Thus, the present western blot results are consistent with evidence suggesting that rosuvastatin enhances the expression of iNOS in myocardial‐infarcted rats and with reports suggesting that statins improve endothelial function through modification of the expression, activity, and enzymatic coupling of eNOS . The involvement of NO and K + channels in the vasorelaxant effect produced by rosuvastatin in aortic rings from rats with a CAF diet was investigated because it was reported that stimulation of NOS and the opening of Ca +2 ‐dependent K + channels are involved in those vasorelaxations to rosuvastatin and methyl ester of rosuvastatin on phenylephrine‐precontracted aortic rings of rats with standard diet . These findings about the involvement of NO and K + channels in the vasorelaxations produced by rosuvastatin on aortic rings of rat with CAF diet are in line with previous reports in which statins produced vasorelaxation and stimulation of NO and K + channels; they also corroborate several reports that suggest that NO and K + channels play an important role in the modulation of vascular tone …”

Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone in vitro to rat aortic rings

“…It should be pointed out that under our experimental conditions, phenylephrine enhanced the vasorelaxant responses produced by amfepramone and acetylcholine (Figure 2). That effect was previously reported in other in vitro studies of acetylcholine and other drugs with vasorelaxant effects (17,21,22). …”

Synthetic Characterization of Complexes of Rosuvastatin and Some ACE Inhibitors: Pharmacological Evaluation

“…Literature survey reveals a number of studies carried on derivatization of ROS [8][9][10][11][12][13][14][15], captopril [16][17][18][19], enalapril [20] and lisinopril [21,22] but there is no study yet present on analogues of ROS and ACE inhibitors. Owing to the tendency of DDI of ROS due to the presence of number of electron donating sites, in vitro interactions were carried out it was reacted with anti-hypertensives and synthesis of complexes of ROS with enalapril, captopril and lisinopril are reported in this paper.…”