High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations

Teixeira, Daniel; Vargens, Daniela D.; Príncipe, Alessandro; Oliveira, Eugénio; Amorim, António; Prata, Maria João; Suarez‐Kurtz, Guilherme

doi:10.1590/s0100-879x2010007500056

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…However, this result is not consistent with a previous study as mentioned above [35], because of analysis of selected 57 pharmacogenes in this study. Although Teixeira et al [36] carried out an MDS analysis for the GSTM3*A/B polymorphism in subSaharan African populations, to the best of our knowledge, this is the first study to use an MDS analysis as part of a frequency analysis of a large number of pharmacogene variants among different populations.…”

Section: Discussionmentioning

confidence: 99%

Ethnic variability in the allelic distribution of pharmacogenes between Korean and other populations

Kim¹,

Kim²,

Chang³

et al. 2012

Pharmacogenetics and Genomics

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In terms of the 57 pharmacogenes studied, there were no significant differences among the KOR, CHB, and JPT populations. However, the YRI and CEU populations were significantly differentiated from the three Eastern Asian groups. Future pharmacogenomics studies can utilize the polymorphisms identified in this study, as these variants may have important implications for the selection of highly informative single nucleotide polymorphisms for future clinical trials.

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Section: Discussionmentioning

confidence: 99%

Ethnic variability in the allelic distribution of pharmacogenes between Korean and other populations

Kim¹,

Kim²,

Chang³

et al. 2012

Pharmacogenetics and Genomics

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Rapid Detection of the GSTM3 A/B Polymorphism Using Real-time PCR with TaqMan® Probes

Martínez-Treviño

Moreno-Treviño

Salinas-Santander

et al. 2016

Archives of Medical Research

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Glutathione S-transferases (GSTs) are a group of phase II detoxification enzymes, which catalyze the conjugation of glutathione (GSH) with carcinogens, among other xenobiotics. The GSTM3 gene is part of the GSTs gene family, and its polymorphism A/B has been associated with risk and protective effects of several cancers. This genetic variant is a deletion of 3 bp (AGG) in intron 6. Previous association studies have performed genotyping using techniques such as polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In this study, we took advantage of the TaqMan(®) probes features and developed a reliable, faster, more simple and economic method to identify the 3-bp deletion. Our allelic discrimination method was able to distinguish between homozygous A/A, heterozygous A/B and homozygous B/B samples, as shown by TaqMan(®) based real-time PCR. Results were validated by Sanger Sequencing. In conclusion, we developed a specific and rapid method to detect the 3-bp deletion from the GSTM3 A/B polymorphism.

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Gene–environment interactions in esophageal cancer

Matejcic

Parker

2015

Critical Reviews in Clinical Laboratory Sciences

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Esophageal cancer (EC) is one of the most common malignancies in low- and medium-income countries and represents a disease of public health importance because of its poor prognosis and high mortality rate in these regions. The striking variation in the prevalence of EC among different ethnic groups suggests a significant contribution of population-specific environmental and dietary factors to susceptibility to the disease. Although individuals within a demarcated geographical area are exposed to the same environment and share similar dietary habits, not all of them will develop the disease; thus genetic susceptibility to environmental risk factors may play a key role in the development of EC. A wide range of xenobiotic-metabolizing enzymes are responsible for the metabolism of carcinogens introduced via the diet or inhaled from the environment. Such dietary or environmental carcinogens can bind to DNA, resulting in mutations that may lead to carcinogenesis. Genes involved in the biosynthesis of these enzymes are all subject to genetic polymorphisms that can lead to altered expression or activity of the encoded proteins. Genetic polymorphisms may, therefore, act as molecular biomarkers that can provide important predictive information about carcinogenesis. The aim of this review is to discuss our current knowledge on the genetic risk factors associated with the development of EC in different populations; it addresses mainly the topics of genetic polymorphisms, gene-environment interactions, and carcinogenesis. We have reviewed the published data on genetic polymorphisms of enzymes involved in the metabolism of xenobiotics and discuss some of the potential gene-environment interactions underlying esophageal carcinogenesis. The main enzymes discussed in this review are the glutathione S-transferases (GSTs), N-acetyltransferases (NATs), cytochrome P450s (CYPs), sulfotransferases (SULTs), UDP-glucuronosyltransferases (UGTs), and epoxide hydrolases (EHs), all of which have key roles in the detoxification of environmental and dietary carcinogens. Finally, we discuss recent advances in the study of genetic polymorphisms associated with EC risk, specifically with regard to genome-wide association studies, and examine possible challenges of case-control studies that need to be addressed to better understand the interaction between genetic and environmental factors in esophageal carcinogenesis.

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High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations

Cited by 3 publications

References 16 publications

Ethnic variability in the allelic distribution of pharmacogenes between Korean and other populations

Ethnic variability in the allelic distribution of pharmacogenes between Korean and other populations

Rapid Detection of the GSTM3 A/B Polymorphism Using Real-time PCR with TaqMan® Probes

Gene–environment interactions in esophageal cancer

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