Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil

Sudo, R. T.; Cunha, L.B.P.; Carmo, Paula Lima do; Matos, Aline da Rocha; Trachez, Margarete M.; Cardoso, Lídia; Aguiar, M.I.S.; Abreu, Antonio Vitor de; Zapata‐Sudo, Gisele

doi:10.1590/s0100-879x2010007500045

Cited by 3 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among 15 studies involved reporting sex differences of MH, 12 studies confirmed that there was a significant difference in MH incidence between males and females 21,26,[31][32][33] with 3 studies suggesting no difference. 22,34,35 It was generally proposed that the incidence of MH in males was more than twice that in females, which was in keeping with the results of most studies included in this review. Moreover, there was a similar sex difference in pediatric patients for the incidence of MH.…”

Section: Sex Differencesupporting

confidence: 77%

“…46 A Canadian study with a sample size of 129 cases showed about 72 (55.8%) cases had CGS scores greater than 35. 38 According to the study Sudo et al, 35 there was a low correlation (32.2%) in low-risk patients (rank 1-2) between CGS and CHCT.…”

Section: Diagnosismentioning

confidence: 96%

“…There were 10 articles involving in age ranges. [19][20][21][22][26][27][28][29][30][32][33][34][35]38,39 Of particular concern was that the majority of people who developed MH were younger than 45 years old, with the average age at morbidity of between 18.5 and 46.5 years old. 21,26 One study in an adult population (>18 years old) showed that the average age at mortality from MH was 31.4 years.…”

Section: Age Characteristicsmentioning

confidence: 99%

“…Among the 24 studies, eight articles recorded CGS scores of patients with MH. 19,26,30,35,38,42,46,48 However, there was marked heterogeneity in CGS scores among different studies. The CGS scores of patients diagnosed with MH ranged from 0 to 73, 26,48 and the median CGS scores were between 30 and 53.4.…”

Section: Diagnosismentioning

confidence: 99%

See 3 more Smart Citations

Epidemiological and clinical features of malignant hyperthermia: A scoping review

Cong,

Wan,

Wang

et al. 2023

Clinical Genetics

View full text Add to dashboard Cite

Malignant hyperthermia (MH) is a potentially fatal inherited pharmacogenetic disorder related to pathogenic variants in the RYR1, CACNA1S, or STAC3 genes. Early recognition of the occurrence of MH and prompt medical treatment are indispensable to ensure a positive outcome. The purpose of this study was to provide valuable information for the early identification of MH by summarizing epidemiological and clinical features of MH. This scoping review followed the methodological framework recommended by Arksey and O'Malley. PubMed, Embase, and Web of science databases were searched for studies that evaluated the epidemical and clinical characteristics of MH. A total of 37 studies were included in this review, of which 26 were related to epidemiology and 24 were associated with clinical characteristics. The morbidity of MH varied from 0.18 per 100 000 to 3.9 per 100 000. The mortality was within the range of 0%–18.2%. Identified risk factors included sex, age, disorders associated with MH, and others. The most frequent initial clinical signs included hyperthermia, sinus tachycardia, and hypercarbia. The occurrence of certain signs, such as hypercapnia, delayed first temperature measurement, and peak temperature were associated with poor outcomes. The epidemiological and clinical features of MH varied considerably and some risk factors and typical clinical signs were identified. The main limitation of this review is that the treatment and management strategies were not assessed sufficiently due to limited information.

show abstract

Section: Sex Differencesupporting

confidence: 77%

Section: Diagnosismentioning

confidence: 96%

Section: Age Characteristicsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological and clinical features of malignant hyperthermia: A scoping review

Cong,

Wan,

Wang

et al. 2023

Clinical Genetics

View full text Add to dashboard Cite

show abstract

“…Dantrolene 120 mg was promptly administered and had very good effects in controlling the hyperthermia and clinical symptoms, although the caffeine halothane contracture test with muscle biopsy, the definite diagnosis of MH susceptibility, was not taken. 12,13 Despite the isoenzymes of CK were not tested in this patient, an unusual high-level CK was noticed, peaking (16,215 IU/L) on postoperative Day 2, suggesting severe rhabdomyolysis. 14 The patient followed a downhill course and eventually died 12 days after surgery.…”

Section: Discussionmentioning

confidence: 84%

Almost-certain malignant hyperthermia during cardiopulmonary bypass: a case report and literature review

Zhang

Zhou

2019

Perfusion

View full text Add to dashboard Cite

Malignant hyperthermia is a well-known but potentially lethal disorder which is triggered by volatile anesthetics and depolarizing muscle relaxants. Early diagnosis and treatment could save lives. However, during cardiac surgery, hypothermia and cardiopulmonary bypass make the diagnosis of malignant hyperthermia extremely difficult than other surgeries. We report a case of almost-certain malignant hyperthermia, according to the clinical grading scale, in a patient undergoing on-pump coronary artery bypass grafting surgery. The patient underwent difficult weaning from cardiopulmonary bypass until intra-aortic balloon pump and temporary cardiac pacemaker had been implanted. Although dantrolene and corresponding treatments were administered recently, the patient died 12 days after surgery because of acute kidney failure and cardiac arrest. Therefore, it is important for us to previously recognize some specific signs of malignant hyperthermia during cardiopulmonary bypass to avoid severe outcomes.

show abstract

Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles

Reggiani

2020

J Muscle Res Cell Motil

View full text Add to dashboard Cite

Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil

Cited by 3 publications

References 34 publications

Epidemiological and clinical features of malignant hyperthermia: A scoping review

Epidemiological and clinical features of malignant hyperthermia: A scoping review

Almost-certain malignant hyperthermia during cardiopulmonary bypass: a case report and literature review

Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles

Contact Info

Product

Resources

About