The first report in Brazil of severe infection caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)

Rozenbaum, Ronaldo; Sampaio, M.G.; Batista, Generosa; Garibaldi, A; Terra, Glaura Martha Florim; Souza, Maria José de; Vieira, E.N.; Silva-Carvalho, Maria Cícera; Teixeira, Lenise Arneiro; Figueiredo, A.M.S.

doi:10.1590/s0100-879x2009005000007

Cited by 30 publications

(26 citation statements)

References 16 publications

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“…Generally, when compared with HA-MRSA, CA-MRSA lineages have different characteristics ( Tristan et al 2007 ). Frequently, these strains are isolated from SSTI; however, although less frequent, more serious infections such as bacteraemia, necrotising pneumonia and fasciitis, endocarditis and osteomyelitis have been reported in different countries (CDC 1999, Dauwalder et al 2008 , Bassetti et al 2010 , Sola et al 2012 ), including Brazil ( Ribeiro et al 2005 , Rozenbaum et al 2009 , Ferreira et al 2012 ). Moreover, these isolates commonly carry SCC mec type IV, V or VII, often harbour lukS and lukF ( lukSF pvl ) genes that encode the S and F subunits of Panton-Valentine leukocidin (PVL) and are usually more susceptible to non-β-lactam antibiotics than HA-MRSA ( Tristan et al 2007 , Sun et al 2013 ).…”

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confidence: 99%

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

Figueiredo

Ferreira

2014

Mem. Inst. Oswaldo Cruz

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important bacterial pathogens based on its incidence and the severity of its associated infections. In addition, severe MRSA infections can occur in hospitalised patients or healthy individuals from the community. Studies have shown the infiltration of MRSA isolates of community origin into hospitals and variants of hospital-associated MRSA have caused infections in the community. These rapid epidemiological changes represent a challenge for the molecular characterisation of such bacteria as a hospital or community-acquired pathogen. To efficiently control the spread of MRSA, it is important to promptly detect the mecA gene, which is the determinant of methicillin resistance, using a polymerase chain reaction-based test or other rapidly and accurate methods that detect the mecA product penicillin-binding protein (PBP)2a or PBP2’. The recent emergence of MRSA isolates that harbour a mecA allotype, i.e., the mecC gene, infecting animals and humans has raised an additional and significant issue regarding MRSA laboratory detection. Antimicrobial drugs for MRSA therapy are becoming depleted and vancomycin is still the main choice in many cases. In this review, we present an overview of MRSA infections in community and healthcare settings with focus on recent changes in the global epidemiology, with special reference to the MRSA picture in Brazil.

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confidence: 99%

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

Figueiredo

Ferreira

2014

Mem. Inst. Oswaldo Cruz

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“…A number of published studies described CA-MRSA strains of SCCmec IV as susceptible to all non-␤-lactam antibiotics (6,18). Also, some CA-MRSA strains can display low-level oxacillin resistance (16).…”

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Detection of New Methicillin-Resistant Staphylococcus aureus Strains That Carry a Novel Genetic Homologue and Important Virulence Determinants

et al. 2012

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In this study, 18 methicillin-resistant Staphylococcus aureus (MRSA) isolates harboring staphylococcal cassette chromosome mec (SCC mec ) type XI, recovered in the Dutch-German Euregio, were characterized by DNA microarrays. In contrast to previous data, we found two MRSA strains of different clonal lineages possessing SCC mec XI that carried important virulence determinants. The worrisome emergence of such toxigenic MRSA strains raises concerns that MRSA strains with enhanced virulence potential and impaired detectability by standard molecular assays may spread in Europe.

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“…However, PVL-positive MRSA-related osteomyelitis has been described previously in children in a number of recent case reports, highlighting the increasing need for clinicians to be aware of its possible presence as the responsible pathogen in community-acquired musculoskeletal infections in this age group [1,7,8].…”

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confidence: 97%

Panton-Valentine leukocidin-positive Staphylococcus aureus osteomyelitis of the tibia in a 10-year-old child

Elledge

Dasari

Roy

2014

Journal of Pediatric Orthopaedics B

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Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is increasing in prevalence among asymptomatic carriers and in cases of paediatric soft-tissue infections alike. CA-MRSA may express virulence factors such as Panton-Valentine leukocidin, which makes soft-tissue and hard-tissue infections due to such organisms challenging to treat. We report a case of osteomyelitis of the proximal tibia in a 10-year-old boy and discuss its management in what is to the authors' knowledge the first case report of Panton-Valentine leukocidin-positive CA-MRSA osteomyelitis in a child in the UK.

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The first report in Brazil of severe infection caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)

Cited by 30 publications

References 16 publications

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

The multifaceted resources and microevolution of the successful human and animal pathogen methicillin-resistant Staphylococcus aureus

Detection of New Methicillin-Resistant Staphylococcus aureus Strains That Carry a Novel Genetic Homologue and Important Virulence Determinants

Panton-Valentine leukocidin-positive Staphylococcus aureus osteomyelitis of the tibia in a 10-year-old child

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