Correction Braz J Med Biol Res 1994; 27(11): 2667-2679 - Analysis of right and left ventricular performance of the rat heart with chronic myocardial infarction

Stefanon, Ivanita; Auxiliadora‐Martins, Maria; Vassallo, Dalton Valentim; Mill, J. G.

doi:10.1590/s0100-879x2009000900015

Cited by 9 publications

(15 citation statements)

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“…Thus, in a previous study, in which an isolated heart preparation was used, perfused with a nutrient solution, a decrease in the systolic pressure was identified, which correlated, in linear form, with the increase in the right ventricular mass 53 .…”

Section: Functional Characteristicsmentioning

confidence: 81%

Infarto do miocárdio experimental em ratos: análise do modelo

Zornoff¹,

Paiva²,

Minicucci³

et al. 2009

Arq. Bras. Cardiol.

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Section: Functional Characteristicsmentioning

confidence: 81%

Infarto do miocárdio experimental em ratos: análise do modelo

Zornoff¹,

Paiva²,

Minicucci³

et al. 2009

Arq. Bras. Cardiol.

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“…Even before the organism presents signs of HF, myocardial contractility is reduced due to post-MI remodeling that results from alterations in key cytoplasmic and membrane proteins involved in the contraction-relaxation cycle (43,44). There are basically two subcellular defects that may contribute to the development of myocardial dysfunction: deranged calcium handling and/or alteration of myofilament responsiveness.…”

Section: Molecular Substrate For Contractile Dysfunctionmentioning

confidence: 99%

Remodeling in the ischemic heart: the stepwise progression for heart

Mill¹,

Stefanon

Santos

et al. 2011

Braz J Med Biol Res

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Coronary artery disease is the leading cause of death in the developed world and in developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in the last decades. However, the incidence of heart failure (HF) in patients with healed infarcted areas is increasing. Therefore, HF prevention is a major challenge to the health system in order to reduce healthcare costs and to provide a better quality of life. Animal models of ischemia and infarction have been essential in providing precise information regarding cardiac remodeling. Several of these changes are maladaptive, and they progressively lead to ventricular dilatation and predispose to the development of arrhythmias, HF and death. These events depend on cell death due to necrosis and apoptosis and on activation of the inflammatory response soon after MI. Systemic and local neurohumoral activation has also been associated with maladaptive cardiac remodeling, predisposing to HF. In this review, we provide a timely description of the cardiovascular alterations that occur after MI at the cellular, neurohumoral and electrical level and discuss the repercussions of these alterations on electrical, mechanical and structural dysfunction of the heart. We also identify several areas where insufficient knowledge limits the adoption of better strategies to prevent HF development in chronically infarcted individuals.

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“…Accepted June 26, 2009. Available online September 4, 2009. Myocardial infarction induces a progressive geometric, structural, and functional remodeling of both ventricles (1)(2)(3)(4). Several adaptive changes resulting from the myocardium infarction, including myocyte hypertrophy (5), increased deposition of extracellular matrix components (6), and chamber enlargement (7,8), seem to depend either on hemodynamic disturbances determined by the loss of contractile tissue (9) or on the neurohumoral activation triggered by myocardial ischemia (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Studies in intact and isolated preparations have suggested that contractile abnormalities may depend on changes in transient calcium concentrations (13) and on the decreased Ca 2+ sensitivity in the contractile machinery of the ventricular myocardium (4,14). The influences of the coronary vasculature and its perfusion on the diastolic properties of the heart and on cardiac contraction have also been well established.…”

Section: Introductionmentioning

confidence: 99%