Circadian cardiac autonomic function in perinatally HIV-infected preschool children

Benchimol-Barbosa, Paulo Roberto

doi:10.1590/s0100-879x2009000800006

Cited by 4 publications

(4 citation statements)

References 36 publications

(49 reference statements)

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“…Beat-to-beat QTc interval measurements from 24-hour ECG recordings may provide additional information since cardiac autonomic nervous activity can modulate the variations of ventricular repolarization [18]. Data on variations of ventricular repolarization over time among HIV-infected patients are scanty [26]. …”

Section: Discussionmentioning

confidence: 99%

QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording

Fiorentini¹,

Petrosillo

Stefano

et al. 2012

BMC Cardiovasc Disord

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BackgroundAim of the study was to assess QTc interval by a 24-hour ECG recording in a group of HIV-infected individuals with a basal prolonged QTc. The risk factors associated with QTc prolongation and the indices of cardiovascular autonomic control were also evaluated.MethodsA case–control study was performed using as cases 32 HIV-infected patients with prolonged (>440 msec) QTc interval as assessed by Holter ECG, and as controls 64 HIV-infected subjects with normal QTc interval. Autonomic function was evaluated by heart rate variability analysis during 24-hour recording.ResultsDuration of HIV disease was significantly longer among cases than among controls (p=0.04). Waist/hip ratio was also higher among cases than among controls (p=0.05). Frequency domain analysis showed the absence of physiologic decrease of low frequency (LF) in the night period in both cases and controls. The LF night in cases showed a statistically significant reduction when compared with controls (p=0.007).ConclusionsIn our study group, QTc interval prolongation was associated with a longer duration of HIV infection and with a greater waist/hip ratio. HIV patients with QTc interval prolongation and with a longer duration of HIV infection were more likely to have an impairment of parasympathetic and sympathetic cardiac component.

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Section: Discussionmentioning

confidence: 99%

QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording

Fiorentini¹,

Petrosillo

Stefano

et al. 2012

BMC Cardiovasc Disord

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“…Abnormalities include attenuation of parasympathetic-mediated circadian rhythm heart rate variability and impairment of night time QTc interval lengthening. 46 …”

Section: Electrophysiologic Abnormalitiesmentioning

confidence: 99%

Cardiovascular manifestations of HIV infection in children

Idris

Grobbee

Burgner

et al. 2014

Eur J Prev Cardiolog

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HIV infection in children may greatly impact the cardiovascular system, including effects on the heart, which tend to manifest early in childhood, and on the vasculature. The underlying mechanisms, essential for targeted prevention, are poorly understood. Current evidence largely stems from research in adults. However, as modes of infection, immune maturity, growth and development, and treatment are markedly different in children, specific pediatric research, accounting for the complex interplay of normal growth and development, HIV infection and treatment, is clearly warranted.

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“… 3 Among potential cardiovascular problems, conduction abnormalities have been rarely studied in HIV-infected children. 4 5 Autopsy showed that various pathologies may occur throughout the conduction system, including vasculitis, myocarditis or fragmentation of the His bundle with fibrosis. 6 In adults, HIV infection is associated with a 20% prevalence of prolonged QTc interval, 7 which potentially induces fatal ventricular arrhythmia, particularly torsade de pointes .…”

Section: Introductionmentioning

confidence: 99%

Effects of paediatric HIV infection on electrical conduction of the heart

et al. 2016

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ObjectiveTo investigate the effects of HIV infection in children on heart electrical conduction, particularly to delineate the effects of HIV infection from treatment.MethodsOn a 12-lead ECG, available for 37 antiretroviral therapy (ART) naïve, 42 ART-exposed vertically-acquired HIV-infected and 50 healthy children in Jakarta, Indonesia, we measured cardiac conduction parameters: PR, QRS, and QTc (corrected using Bazett's formula) intervals. The associations between HIV infection/treatment status and ECG intervals were evaluated using general linear modelling with further adjustment for potential confounders or intermediary variables. Findings are presented as (adjusted) mean differences between each of the two HIV groups and healthy children.ResultsAlthough not exceeding the clinical threshold for long QT (QTc >460 ms for girls and >440 ms for boys) compared to healthy children, mean QTc intervals were longer in ART-naïve (difference 18.2 ms, 95% CI 7.0 to 29.3) and, to greater extent, in ART-exposed HIV-infected children (difference 28.9 ms, 19.3 to 38.5). Following adjustment for RR interval, age and height, prolongation of PR interval was seen only in ART-naïve HIV-infected children (difference 12.9 ms, 2.4 to 23.3). Cardiac mass/function, high-sensitive C reactive protein, cholesterol and glycated haemoglobin levels, systolic and diastolic blood pressures, or postnatal parental smoking exposure did not affect these associations. No difference in the QRS interval was observed between groups.ConclusionsProlongation of the QTc interval occurs in ART-naïve HIV-infected children and, to a greater extent, in the ART-exposed children, whereas a longer PR interval appears to be seen only among ART-naïve HIV-infected children.

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Circadian cardiac autonomic function in perinatally HIV-infected preschool children

Cited by 4 publications

References 36 publications

QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording

QTc interval prolongation in HIV-infected patients: a case–control study by 24-hour Holter ECG recording

Cardiovascular manifestations of HIV infection in children

Effects of paediatric HIV infection on electrical conduction of the heart

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