2009
DOI: 10.1590/s0100-879x2009000700004
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Effect of postnatal malnutrition on hyperoxia-induced newborn lung development

Abstract: Several factors are associated with bronchopulmonary dysplasia. Among them, hyperoxia and lung immaturity are considered to be fundamental; however, the effect of malnutrition is unknown. Our objective was to evaluate the effects of 7 days of postnatal malnutrition and hyperoxia on lung weight, volume, water content, and pulmonary morphometry of premature rabbits. After csection, 28-day-old New Zealand white rabbits were randomized into four groups: control diet and room air (CA, N = 17), control diet and ≥95%… Show more

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Cited by 34 publications
(37 citation statements)
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References 35 publications
(55 reference statements)
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“…Similar findings of the body weight, lung weight and lung weight to body weight ratio in protein restricted group were mentioned by other studies [14,17]. The decrease in body weight, lung weight and lung weight to body weight ratio at day 1 and 14 may be due to decrease in the amount of protein content in the body and organs which was essential component of tissue elements, but the increased lung weight to body weight ratio at 2 months may be due to decrease in lung weight more than body weight or increase in the body weight which caused by fluid retention resulted from hypo-albuminaemia.…”
Section: Discussionsupporting
confidence: 91%
“…Similar findings of the body weight, lung weight and lung weight to body weight ratio in protein restricted group were mentioned by other studies [14,17]. The decrease in body weight, lung weight and lung weight to body weight ratio at day 1 and 14 may be due to decrease in the amount of protein content in the body and organs which was essential component of tissue elements, but the increased lung weight to body weight ratio at 2 months may be due to decrease in lung weight more than body weight or increase in the body weight which caused by fluid retention resulted from hypo-albuminaemia.…”
Section: Discussionsupporting
confidence: 91%
“…The smallest species in which in utero manipulation like intra-amniotic or direct intravenous or intratracheal injections during the saccular or initial alveolar phase of development can be modeled is the rabbit. The use of preterm born rabbits has been previously described to study neonatal nutrition (5), the antioxidant system (31), intraventricular hemorrhage (3), the effect of betamethasone (29), or hyperoxia exposure (21,22). The latter two studies have provided very important information about the housing and feeding of premature rabbits as well as insights in the lung pathology after hyperoxic exposure.…”
Section: Discussionmentioning
confidence: 99%
“…The feeding consisted of a mixture of soybean oil (Intralipid 30%, 270 kcal/100 ml; Fresenius Kabi), pure casein (100% Casein, 360 kcal/100 mg; Optimum Nutrition), pediatric milk formula (Nutrilon HA nr 2, 453 kcal/100 mg; Nutricia), and water. This mixture gives a nutritional value of 16 g lipids, 5.3 g proteins, 2.7 g carbohydrates (176 kcal in total)/100 ml and was chosen in accordance to prior studies using a preterm rabbit model (21,22). The amount of feeding steadily increased from 80 to 100 to 150 to finally 200 mg·kg Ϫ1 ·day Ϫ1 on days 0, 1, 2, and 3 (until 7), respectively.…”
Section: Methodsmentioning
confidence: 99%
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