Identifying reasons for failure in biomedical research and publishing

Bousfield, Derek R.

doi:10.1590/s0100-879x2009000700001

Cited by 5 publications

(3 citation statements)

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“…In Latin America, training in clinical research methodology is limited in the medical school curriculum and doctors are not familiar with the use of different tools to perform clinical investigation. [25][26][27][28] Ideally the training of future researchers should have a direct involvement in the practical aspects of clinical research and globalization. 29 They should be under the supervision of faculty members who are accomplished investigators and learn how to review published data, research design, data collection, data analysis and research ethics.…”

Section: Resultsmentioning

confidence: 99%

Clinical research in Latin America: scientific production in high impact clinical research journals from 2000 to 2010

Coronel

Fregni

2015

Int J Clin Trials

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Background: Scientific production has long been dominated by a few countries such as the United States, Europe and Japan. Historically Latin American countries have contributed marginally to the world's scientific production, however important changes are now taking place in the geography of scientific research. Methods: In order to determine the current contribution of Latin America to global clinical research and whether the region has been participating in the growth of internationally collaborative research we reviewed the literature in 10 high-impact medical journals between 2000 and 2010. We manually searched original articles in 10 journals that have a strong focus on clinical research and had the highest impact factors in their fields during the study period. We identified a total of 1047 original articles published. Results: Our results show that Latin America was a minor contributor of research published in high impact journals with only 4 (0.38%) of the articles citing a corresponding author affiliated with a Latin American institution. Furthermore, only 23 articles (2.2%) cited non-corresponding authors from Latin America in contrast to 358 articles (34.2%) in which all the authors were affiliated with US institutions. Conclusions: Although these results show limited contribution from Latin America to the production of health and clinical research, it also shows that Latin America is represented in the most competitive journals given the relative lack of research infrastructure , training and challenges with language. Factors such as GDP and investment in research may play a significant role, but may not be the only contributing factors for this scenario.

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Section: Resultsmentioning

confidence: 99%

Clinical research in Latin America: scientific production in high impact clinical research journals from 2000 to 2010

Coronel

Fregni

2015

Int J Clin Trials

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“…This subject has certainly http://dx.doi.org/10.1590/S1519-38292014000400001 generated great interest. It is therefore surprising that, thirty years later, methodological errors can still be found in scientific studies, at least in the fields of biology, sociology, psychology and medicine, as identified by Ioannides himself 4 in 2005 and Bousfield 8 in 2009, which has also led to high rates of non-publication.…”

Section: The Importance Of the Quality Of The Methodology In Researchmentioning

confidence: 99%

A importância da qualidade da Metodologia na Pesquisa

Filho¹

2014

Rev. Bras. Saude Mater. Infant.

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“…Our intention was to create a science game that would be educational, but also challenging and interesting enough to ensure player engagement. We also decided to perform the first version in Portuguese to avoid any language barrier that could hamper the widespread use of this game, knowing that the English skills of undergraduate and graduate students in Brazil is often relatively poor ( 7 ). Our main target audience was students enrolled in postgraduate programs in pharmacology, medicinal chemistry, toxicology, pharmacy, and medicine as they can benefit from understanding that DDD is a team effort of individual scientists with highly specific expertise working on the same project.…”

Section: Introductionmentioning

confidence: 99%

SCREENER, an educational game for teaching the Drug Discovery and Development process

Noël

Xexéo

Mangeli

et al. 2021

Braz J Med Biol Res

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Although the use of games as an educational strategy is an important current trend, there is practically no option available for training people on the Drug Discovery and Development (DDD) process. To fill this gap, we designed “SCREENER”, a science game that is intended to be educational, but also challenging and interesting enough to ensure player engagement. Our main target audience is students of postgraduate programs in pharmacology, medicinal chemistry, pharmacy, and medicine. This game could also be of interest to the pharmaceutical industry and regulatory and patent agencies for training new employees. We discuss the creation of SCREENER, a hybrid of board and card games, and present its components with some examples of cards and resources, as well as the dynamics of the game. SCREENER mimics the process of drug discovery and development from validating a target to registering the new drug with the regulatory agency, and can be played individually (self-learning) or with the help of a monitor who assists up to six players/teams. Briefly, 29 task cards categorized in four major areas (efficacy, safety, pharmacokinetics, and pharmaceutical development) must be purchased sequentially. Classic characteristics of games such as decision making and challenge have been incorporated. More in-depth information on the tasks and technical terms is available through QR codes. The vagaries of the DDD process are mimicked by the bonus/setback cards. The evaluation of our first test with students is presented and supports the usefulness of this new tool.

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Identifying reasons for failure in biomedical research and publishing

Cited by 5 publications

References 1 publication

Clinical research in Latin America: scientific production in high impact clinical research journals from 2000 to 2010

Clinical research in Latin America: scientific production in high impact clinical research journals from 2000 to 2010

A importância da qualidade da Metodologia na Pesquisa

SCREENER, an educational game for teaching the Drug Discovery and Development process

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