2008
DOI: 10.1590/s0100-879x2008000700002
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Abstract: It is well known that the ventrolateral medulla contains neurons involved in the tonic and reflex control of the cardiovascular system. Two regions within the ventrolateral medulla were initially identified: the rostral ventrolateral medulla (RVLM) and the caudal ventrolateral medulla (CVLM). Activation of the RVLM raises arterial blood pressure and sympathetic nerve activity, and activation of the CVLM causes opposite effects. The RVLM premotor neurons project directly to sympathetic preganglionic neurons and… Show more

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Cited by 21 publications
(17 citation statements)
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“…Curiously, Feldberg and Guertzenstein (1986) described a similar anaesthetic sensitivity in their first description of the 'CPA' in cat where a pressor response was only obtained during very deep anaesthesia and further following pretreatment of a ventral surface site with pentobarbitone, leptazol evoked a much larger rise in pressure. Despite intensive investigation considerable confusion still surrounds the location of the so called 'CPA' (Campos et al, 2008;Campos and McAllen, 1999;Gordon and McCann, 1988;Horiuchi and Dampney, 2002;Natarajan and Morrison, 2000;Possas et al, 1994;Silva et al, 2001;Panneton, 2005, 2002;Tolentino-Silva et al, 1997;Yajima et al, 2008;Feldberg and Guertzenstein, 1986;Panneton et al, 2008). We suggest, in light of the present study, this confusion is due to the existence of three caudal pressor regions.…”
Section: 'Cardiovascular' Regionsmentioning
confidence: 55%
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“…Curiously, Feldberg and Guertzenstein (1986) described a similar anaesthetic sensitivity in their first description of the 'CPA' in cat where a pressor response was only obtained during very deep anaesthesia and further following pretreatment of a ventral surface site with pentobarbitone, leptazol evoked a much larger rise in pressure. Despite intensive investigation considerable confusion still surrounds the location of the so called 'CPA' (Campos et al, 2008;Campos and McAllen, 1999;Gordon and McCann, 1988;Horiuchi and Dampney, 2002;Natarajan and Morrison, 2000;Possas et al, 1994;Silva et al, 2001;Panneton, 2005, 2002;Tolentino-Silva et al, 1997;Yajima et al, 2008;Feldberg and Guertzenstein, 1986;Panneton et al, 2008). We suggest, in light of the present study, this confusion is due to the existence of three caudal pressor regions.…”
Section: 'Cardiovascular' Regionsmentioning
confidence: 55%
“…Natarajan and Morrison (2000) also propose the existence of relay neurons from the CPA that are excitatory, located in or around the vasodepressor CVLM region, a proposal supported by data presented here. We have previously demonstrated that the pressor responses evoked from MCPA are independent of the RVLM (Seyedabadi et al, 2006) whereas those evoked from some described CPA sites are dependent upon the integrity of the RVLM (Campos et al, 2008;Gordon and McCann, 1988;Horiuchi and Dampney, 2002;Natarajan and Morrison, 2000). Thus our impression is that past investigations of the 'CPA' may have been exploring more than one pressor area.…”
Section: 'Cardiovascular' Regionsmentioning
confidence: 99%
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“…In this regard, the rostral ventrolateral medulla (RVLM) is an important region for the maintenance of the hypertension. 24,25 Because the RVLM is a key regulatory of sympathetic activity, 26 a change in ROS activity here may be an essential mechanism involved in generating excessive sympathetic activity in the 2K-1C model. We identified an imbalance between ROS generation and oxidant scavenging in the RVLM that promoted O 2 ⅐Ϫ generation.…”
mentioning
confidence: 99%
“…Alternatively, circuits of the rostral (RVLM) and caudal (CVLM) ventrolateral medulla groups are responsible for the tonic and reflex control of cardiovascular function. Neuronal activities in these two groups are opposing as the stimulation of the RVLM increases blood pressure and sympathetic nerve activity in sharp contrast to the CVLM (Campos et al, 2008). The changes could result from peripheral reflexes or descending signals from central structures such as the hypothalamus and cerebral cortex (Guyenet, 2006;Thomas, 2011).…”
Section: Brainstem Circuits Involved In Generating and Driving Respirmentioning
confidence: 99%