Correction Braz J Med Biol Res 2007; 40(4): 583-590 Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I-converting enzyme deletion/deletion genotype

Abstract

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Proteolytic Processing of Angiotensin-I in Human Blood Plasma

“…The generated calibration curves of the angiotensin peptides ANG-1-10, ANG-4-10 and ANG-5-10 indicate cross-reactions of the immuno-fluorescence assay ANG-1-10-antibody with all peptides comprising the same C-terminus as ANG-1-10. Thus we confirm the finding of Velloso et al , who reported about 100% cross reaction of an ANG-1-10-antibody with ANG-3-10 and ANG-4-10 [33]. This finding is crucial concerning the direct measurement of ANG-1-10 in plasma by comparable antibody based assays, as the presence of peptides which derive from N-terminal cleavage of ANG-1-10 might lead to falsified quantification of the examined angiotensin peptide if the plasma peptides are not separated from each other prior to their quantification.…”