TNF-a and IL-10 levels in tracheobronchial lavage of ventilated preterm infants and subsequent lung function

Corso, Andrea; Pitrez, Paulo Márcio; Stein, Renato T.; Jones, Marcus Herbert

doi:10.1590/s0100-879x2007000400016

Cited by 3 publications

(1 citation statement)

References 39 publications

(62 reference statements)

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“…The expression and release of pro-inflammatory cytokines in the lung have been implicated in the etiology of BPD, 11 in association with chorioamnionitis, 12 and prolonged mechanical ventilation. 13,14 Nosocomial RVIs may exacerbate inflammation attributable to positive pressure ventilation, prematurity, and/or supplemental oxygen therapy, and may contribute to the development of chronic lung disease of prematurity. The effect of RVI on length of stay appeared to be mediated through effects on the respiratory system.…”

Section: Discussionmentioning

confidence: 99%

Unrecognized Viral Respiratory Tract Infections in Premature Infants during their Birth Hospitalization: A Prospective Surveillance Study in Two Neonatal Intensive Care Units

Bennett

Tabarani

Bartholoma

et al. 2012

The Journal of Pediatrics

101

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Objective We sought to determine the frequency and effects of nosocomial respiratory viral infections (RVIs) in premature neonates, including those who may be asymptomatic. Study Design We performed a year-long surveillance for RVIs in infants <33 weeks gestational age admitted to two Syracuse neonatal intensive care units (NICUs). Infants were enrolled within 3 days of NICU admission and were sampled for RVIs until discharge using a multiplex PCR assay capable of detecting 17 different respiratory viruses or subtypes. Results 26 of 50 prematurely born infants (52%) tested positive for a respiratory virus at least once during their birth hospitalization. Testing positive for a respiratory virus was significantly associated with longer length of stay (70 days vs. 35 days, p = 0.002) and prolonged ventilatory support (51 vs. 13 days, p = 0.002). Infants who tested positive for a respiratory virus during their birth hospitalization had more than twice the rate of developing bronchopulmonary dysplasia (BPD; p < 0.05). Conclusion Nosocomial RVIs were frequent in our study population, despite the absence of clinical indicators of illness. Length of hospital stay was significantly longer and a diagnosis of BPD was more common in those premature infants who had respiratory viruses detected.

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Section: Discussionmentioning

confidence: 99%