Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats

Moreno, Silvana Ramos Farías; Silva, A L C; ., G.F. Diré; Honeycut, Hayden; Carvalho, Jorge José de; Nascimento, Ana Lúcia Rosa; Pereira, Mário; Rocha, Emely Kazan; Oliveira-Timóteo, M; Arnóbio, Adriano; Olej, Beni; Bernardo-Filho, Mário; Caldas, L.Q.A.

doi:10.1590/s0100-879x2007000100010

Cited by 24 publications

(17 citation statements)

References 9 publications

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“…It can reduce the uptake of radiobiocomplex sodium pertechnetate in heart (Moreno et al 2007a). Again, this may decrease the visualization of the organ, requiring a repeat procedure.…”

Section: Heartmentioning

confidence: 99%

Radiopharmaceuticals drug interactions: a critical review

Santos-Oliveira

Smith

Carneiro-Leão

2008

An. Acad. Bras. Ciênc.

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Radiopharmaceuticals play a critical role in modern medicine primarily for diagnostic purposes, but also for monitoring disease progression and response to treatment. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications and radiopharmaceuticals. These interactions which have an impact on image by competing with the radiopharmaceutical for binding sites for example can lead to false negative results. Drugs that accelerate the metabolism of the radiopharmaceutical can have a positive impact (i.e. speeding its clearance) or, if repeating image is needed, a negative impact. In some cases, for example in cardiac image among patients taking doxirubacin, these interactions may have a therapeutic benefit. The incidence of drug-radiopharmaceuticals adverse reactions is unknown, since they may not be reported or even recognized. Here, we compiled the medical literature, using the criteria of a systematic review established by the Cochrane Collaboration, on pharmaceutical-drug interactions to provide a summary of documented interactions by organ system and radiopharmaceuticals. The purpose is to provide a reference on drug interactions that could inform the nuclear medicine staff in their daily routine. Efforts to increase adverse event reporting, and ideally consolidate reports worldwide, can provide a critically needed resource for prevention of drug-radiopharmaceuticals interactions.

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“…It can reduce the uptake of radiobiocomplex sodium pertechnetate in heart (Moreno et al 2007a). Again, this may decrease the visualization of the organ, requiring a repeat procedure.…”

Section: Heartmentioning

confidence: 99%

Radiopharmaceuticals drug interactions: a critical review

Santos-Oliveira

Smith

Carneiro-Leão

2008

An. Acad. Bras. Ciênc.

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“…It has already reported that the biodistribution of radiopharmaceuticals used in diagnostic imaging in nuclear medicine is also altered by including plant origin drugs (Hesslewood & Leung, 1994;Britto et al, 1998;Gomes et al, 2001;Mattos et al, 1999). It has been described that extracts of medicinal plants could interfere with the biodistribution of 99m Tc sodium pertechnetate particularly (Rebello et al, 2007;Rebello et al, 2008;Bernardo-Filho et al, 2005;Moreno et al, 2007;Jankovic & Djokic, 2005;Valenca et al, 2005). In these studies, alterations on the uptake of radiopharmaceutical were observed.…”

Section: Introductionmentioning

confidence: 99%

Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats

Zora¹,

Müftüler²,

Demir³

et al. 2012

Rev. bras. farmacogn.

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Abstract:In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99m Tc-DTPA and its blood cells uptake. DTPA was labeled with 99m Tc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99m Tc-DTPA in kidneys and in blood cells. 99m Tc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99m Tc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.

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“…Radiobiocomplexes may be prepared with technetium-99m (Tc-99m), as sodium pertechenetate ( 99m TcO 4 Na), and used as imaging agents (Hladik III et al, 1987;Saha, 2004). The bioavailability of radiobiocomplexes can be recognizably altered by a wide variety of conditions, such as, drug therapy, radiation therapy, diseases and medicinal plant therapy Oliveira et al, 2003;Bernardo-Filho et al, 2005;Moreno et al, 2007a;Moreno et al, 2007b). As the investigation of herbs interaction with cells is highly relevant and necessary, and also there are studies suggesting the association of some constituents of Ginkgo biloba (EGb) with possible toxic effects, the purpose of this work was: (i) to evaluate the influence of a Ginkgo biloba extract (EGb 761) on the ultrastructure (electronic microscopy) of some organs isolated from Wistar rats treated with this extract and (ii) to assess the effect of this extract on the biodistribution of the sodium pertechnetate.…”

Section: Introductionmentioning

confidence: 99%