Impairment of cytomegalovirus-specific cellular immune response as a risk factor for cytomegalovirus disease in transplant recipients

Effects of the Intensity of Immunosuppressive Therapy on Outcome of Treatment for CMV Disease in Organ Transplant Recipients

“…This was more common in patients who had not seroconverted prior to infection and may be an indication of an impaired host immune system (31,32 …”

Diagnostic Utility of Human Cytomegalovirus-Specific T-Cell Response Monitoring in Predicting Viremia in Pediatric Allogeneic Stem-Cell Transplant Patients

“…In allogeneic HSCT patients, it is well established that the most critical conditions occur in CMV seronegative donor (DϪ) of CMV seropositive recipients (Rϩ), because in this settings CMV may replicate in absence of an adequate immune response (17,(25)(26)(27)(28)(29)(30)(31)(32). However, CMV seropositive donors (Dϩ) may also experience occurrence of CMV infection and disease as several factors may influence antiviral immunological recovery.…”

Alterações bucais e cuidados orais no paciente transplantado de medula óssea

“…54 As lesões orais por CMV não apresentam características clínicas específicas, com tendência à formação de úlceras irregulares e profundas e superfície recoberta por pseudomembrana. 55 O diagnóstico pode ser obtido através de biópsia e análise imunoistoquímica específica para CMV. Ganciclovir é a droga de escolha para o tratamento das infecções por CMV; 54 em casos de resistência a esta droga, derivadas principalmente de terapias preventivas para esse vírus, drogas que inibem a DNA polimerase do vírus (Foscarnet e Cidofovir) têm sido usadas.…”