Peripheral markers of oxidative stress in chronic mercuric chloride intoxication

Gutiérrez-Carrasquilla, Liliana; Mazzotti, Nicolle Gollo; Araújo, Alex Sander; Klipel, R.B.; Fernandes, Tania Regina Gattelli; Llesuy, Susana; Belló‐Klein, Adriane

doi:10.1590/s0100-879x2006000600009

Cited by 25 publications

(15 citation statements)

References 18 publications

(16 reference statements)

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“…It has been shown that heavy metals such as mercury, lead and thallium reduce antioxidative enzymes such as SOD, CAT, GLU and Lipid peroxidase (LPO) (Woodside et al, 2005;Farina et al, 2013). The present study agrees with the findings that showed that oxidative stress was an important component of the mechanism of toxicity by heavy metals (Gutierrez et al, 2006). It has been shown that acute exposure to mercury increases LPO and decreases SOD levels in experimental animals.…”

Section: Discussionsupporting

confidence: 92%

The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

Ao¹,

Aa²,

Ayuba³

et al. 2014

Afr. J. Cell. Path

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Aim: The present study was aimed at evaluating the effect of ascorbic acid on mercury-induced changes on the cerebellar cortex of adult Wistar rats. Methods: Thirty adult Wistar rats of average weight of 200g were randomly divided into 6 groups of 5 rats each. The animals in Group 1 (control) were administered with distilled water, Groups 2 and 3 were administered with 52mg/kg and 26.25mg/kg body weight of HgCl 2 respectively while Groups 4 and 5 were administered with 52mg/kg of HgCl 2 and 5mg/kg of ascorbic acid and 26.25gm/kg of HgCl 2 and 5mg/kg of ascorbic acid respectively, while Group 6 was administered with 5mg/kg of ascorbic acid. The administration was through the oral route, daily for 3 weeks and the animals were humanely sacrificed. Thereafter, blood and tissue samples were harvested for analysis. Results: The result of the biochemical parameters showed a significant increase (P<0.05) in the mean SOD and LPO values after the administration of mercuric chloride and ascorbic acid. Histological observation of the cerebellar cortex showed normal histo-morphology in Groups 1 and 6 while, the cerebellum in Groups 2, 3, 4 and 5 showed some degenerative, necrotic and cellular changes. Conclusion: Ascorbic acid administration has shown to ameliorate the induced degenerative changes in the cerebellum caused by mercuric chloride toxicity in Wistar rats.

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Section: Discussionsupporting

confidence: 92%

The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

Ao¹,

Aa²,

Ayuba³

et al. 2014

Afr. J. Cell. Path

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“…These changes might mean that antioxidant defenses are effectively related to endothelial venous function improvement induced by dialysis, because patients with major improvement in endothelial function presented the lower TRAP reduction. Oxidative stress was measured through a very sensitive method that involves chemiluminescence, allowing high precision determinations with small amounts of sample (23). One limitation of our study was that we did not measure systemic inflammatory mediators that could be related to chronic renal failure itself and also to the hemodialysis session (24), since changes in these mediators could partially explain the endothelial function improvement.…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis improves endothelial venous function in end-stage renal disease

Silva

Signori

Plentz

et al. 2008

Braz J Med Biol Res

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The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential -TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP (402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/µL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect.

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“…They increase oxidative stress and decrease intracellular levels of glutathione in vitro. Chronic administration of HgCl 2 to rats caused an imbalance in oxidative stress and a significant decrease in the animal's body weight compared with control [6].…”

Section: Introductionmentioning

confidence: 87%

Effect of radioactive and non-radioactive mercury on wheat germination and the anti-toxic role of glutathione

Popa¹,

Murariu²,

Molnar³

et al. 2007

Isotopes in Environmental and Health Studies

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Studies to test the noxious effect of mercury ions on wheat germination and seedling growth showed that germination rate, shoot length, and fresh weights varied as a function of their concentration in the treatment solutions. At the same concentration, the radioactive mercury proved to be more harmful to the living seeds and seedlings. The detoxification action of glutathione for both radioactive and non-radioactive mercury was also followed. After a seven-day period of germination in the presence of the investigated compounds, the wheat plantlets were cut from the seeds, and their height, weight, and residual radioactivity were measured. The shoot length decreased from 8.1 (blank) to 4.6 cm (non-radioactive mercury) or even to 2.5 cm ((203)Hg), while glutathione had both an anti-toxic and an anti-radiotoxic effect (6.4 and 6.0 cm, respectively). The root weight of the lot decreased from 1.7 to 0.7 g and 0.4 g, respectively, while glutathione showed a healing action (1.5 and 1.7 g). The radioactive ions accumulated especially in roots (35.5 %), and less in shoots (11.2 %). Results were statistically validated.

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Peripheral markers of oxidative stress in chronic mercuric chloride intoxication

Cited by 25 publications

References 18 publications

The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

Hemodialysis improves endothelial venous function in end-stage renal disease

Effect of radioactive and non-radioactive mercury on wheat germination and the anti-toxic role of glutathione

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