Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

Tanrıverdi, Taner; Sanuş, Galip Zihni; Ulu, Mustafa Onur; Türeci, Ercan; Uzun, Hafize; Aydın, Seval; Kaynar, Mehmet Yaşar

doi:10.1590/s0100-879x2005001100020

Cited by 20 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, E-selectin levels appeared to be higher in patients with CV than in those without CV. 20,22 In contrast, Gaetani et al 17 found no association between E-selectin level and SAH or CV; however, they analyzed cisternal CSF with RIA rather than ventricular CSF with ELISA. …”

Section: E-selectinmentioning

confidence: 98%

Proteomic Biomarker Discovery in Cerebrospinal Fluid for Cerebral Vasospasm Following Subarachnoid Hemorrhage

Lad¹,

Hegen²,

Gupta³

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

Section: E-selectinmentioning

confidence: 98%

Proteomic Biomarker Discovery in Cerebrospinal Fluid for Cerebral Vasospasm Following Subarachnoid Hemorrhage

Lad¹,

Hegen²,

Gupta³

et al. 2012

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

“…On the other hand, CSF may be more reliable when tested together with serum E-selectin. Tanriverdi 25 et al found that serum and CSF Eselectin levels were significantly increased in aneurismal SAH patients as compared with patients with hydrocephalus.…”

Section: A 1bmentioning

confidence: 99%

E-Selectin Expression Increased in Human Ruptured Cerebral Aneurysm Tissues

Jia

Wang

Zhao

et al. 2011

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

The prevalence of intracranial aneurysm in humans is about 6% 1,2 . Data from the United States show 200 million to 1 billion people worldwide with unruptured aneurysm 3 . Most aneurysm patients die of rupture of the aneurysms with subarachnoid hemorrhage (SAH) and following vasospasm. Therefore, the reasons behind cerebral aneurysm rupture is of the most important factors under investigation. Even though hemodynamics studies showed blood flow and intralumenal pressure change had major effect on the formation of aneurysms, which based on other evidences, such as the fact that cerebral aneurysms characteristically occur at the branch points of major cerebral arteries and, more commonly, at the internal carotidposterior communicating artery and anterior cerebral-anterior communicating artery junctions, more and more research reveals that inflammation reactions might be another important factor in the formation and rupture of cerebral aneurysms. ABSTRACT: Objectives:The purpose of the present study is to investigate the expression of inflammation factor endothelial-leukocyte adhesion molecule (E-selectin, CD62E) in cerebral aneurysm walls and its relationship with aneurysm rupture. Methods: Cerebral aneurysm tissue samples were collected at the time of surgical clipping of nine patients with history of subarachnoid hemorrhage, and then compared with control artery tissues from the superficial temporal arteries (STA) of five patients with intracranial tumors. Immunohistochemistry (IHC) was performed to reveal and localize E-selectin expression in the aneurysms and artery tissues. Western blot analysis was used to relatively quantify the level of E-selectine protein expression in cerebral aneurysms when compared with normal arteries. Results: E-selectin was detected in the wall of all the aneurysm tissue samples and was rarely found in normal control arteries by IHC, and it was concentrated in proliferating and disorganized epithelia cells. Moreover, with the Western blot method, the E-selectin protein level increased significantly in aneurysm tissues compared to normal STA. Conclusions: E-selectin might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls.

show abstract

“…Correspondingly, but not addressing the acute phase, selective endothelin-A receptor antagonists have been found to ameliorate delayed vasospasm (7). Cell adhesion molecules (CAMs) and E-selectin in particular have also been advocated to participate in the development of vasospasm through very early steps of an inflammatory response, as they increase rapidly after SAH in both CSF and plasma (127,128). It has been argued, however, that most inflammatory changes are less likely to occur during the very acute phase due to their timeconsuming nature of initiation as expertly outlined in a overview by Sercombe et al (129).…”

Section: Acute Vasospasmmentioning

confidence: 99%

Cerebral blood flow changes in acute subarachnoid hemorrhage

Schubert¹

2008

Front Biosci

View full text Add to dashboard Cite

Delayed vasospasm and secondary injury due to ischemia occur frequently in the setting of subarachnoid hemorrhage (SAH), and these changes have been well characterized within the last decades. Considerable effort has also been put into the development of therapeutic strategies and appropriate monitoring modalities. However, although in particular acute injury is known to contribute significantly to overall outcome in SAH, these immediate alterations still remain largely neglected in current research. Few studies exist to date which mainly describe rapid alterations in perfusion and metabolism. As the main characteristic of the very first minutes and hours after SAH, an immediate phase of CPP-independent hypoperfusion has been observed repeatedly both experimentally and clinically, and it has mostly been attributed to the development of acute vasospasm. Endothelin and nitric oxide, prime suspect in the pathogenesis of chronic vasospasm, may play a pivotal role in this early scenario, possibly being promoted by the drastic ICP increase and extravasation of blood compounds. The much disputed concept of inflammation in chronic vasospasm may not be applicable this early after the ictus, but mechanisms of cellular and structural changes causing microvascular platelet aggregation and immediate disruption of the basal lamina, however, are thought to contribute significantly to the imminent cascade of disturbances in perfusion and metabolism. This review is intended to summarize current insights and illustrate recent efforts to better understand alterations in cerebral perfusion in these very first minutes and hours after SAH which--at some point--may also be amenable to early therapeutic intervention.

show abstract

Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

Cited by 20 publications

References 36 publications

Proteomic Biomarker Discovery in Cerebrospinal Fluid for Cerebral Vasospasm Following Subarachnoid Hemorrhage

Proteomic Biomarker Discovery in Cerebrospinal Fluid for Cerebral Vasospasm Following Subarachnoid Hemorrhage

E-Selectin Expression Increased in Human Ruptured Cerebral Aneurysm Tissues

Cerebral blood flow changes in acute subarachnoid hemorrhage

Contact Info

Product

Resources

About