The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder

Crippa, José Alexandre S; Uchida, Ricardo Riyoiti; Busatto, Geraldo F.; Guimarães, F.S.; Del-Ben, Cristina Marta; Zuardi, Antônio Waldo; Santos, Antônio Carlos dos; Araújo, David; McGuire, Philip; Graeff, Frederico Guilherme

doi:10.1590/s0100-879x2004000300013

Cited by 14 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Morphological brain abnormalities were evaluated in each study, and only four of them [13][14] have detected no significant differences between the patient and control groups.…”

Section: Resultsmentioning

confidence: 99%

“…69 Supporting this notion, another study detected a high frequency of cavum septi pellucidum (CSP) in patients with PD who presented EEG abnormalities. 70 More recently, Crippa et al 14 investigated the prevalence and size of the CSP in 21 PD patients compared to 21 healthy controls, but no significant differences were detected between groups by manual, ROI-based methods. The first study on PD patients using VBM-based methods detected a reduction of gray matter in the left parahippocampal gyrus of PD patients.…”

Section: -52mentioning

confidence: 99%

See 1 more Smart Citation

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: The aim of the present report is to present a systematic and critical review of the more recent literature data about structural abnormalities detected by magnetic ressonance in anxiety disorders. Method: A review of the literature in the last five years was conducted by a search of the Medline, Lilacs and SciELO indexing services using the following key words : "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" and "obsessive-compulsive", crossed one by one with "magnetic resonance", "voxel-based", "ROI" and "morphometry palavras-chave: "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" e "obsessive-compulsive" cruzadas uma a uma com "magnetic ressonance", "voxel-based", "ROI" e "morphometry

show abstract

“…Morphological brain abnormalities were evaluated in each study, and only four of them [13][14] have detected no significant differences between the patient and control groups.…”

Section: Resultsmentioning

confidence: 99%

Section: -52mentioning

confidence: 99%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…1,5 There is no clear cutoff value to define enlargement of the CSP, but many previous studies used a common cutoff of Ն6 mm. 2,3,[5][6][7][8][9][10][11][12][13][14][15][16] In patients with schizophrenia and an enlarged CSP, smaller amygdala volumes and smaller left posterior parahippocampal gyrus volumes compared with patients without CSP were found. 12 Other studies did not find a relation to global or specific brain structure volumes.…”

mentioning

confidence: 90%

“…The presence of an enlarged CSP, according to the Ն6-mm cutoff varied from 0% to 19.5% in patients and from 0% to 14.7% in controls. 2,3,[6][7][8][9][10][11][12][13][14][15][16] Because control groups for clinical studies do not always reflect the general population, the prevalence of an enlarged CSP in the general pediatric population is unknown. Thus, the goal of this study was to determine the prevalence of a CSP in the general pediatric population and to examine the relationship between the size of a CSP and brain structure volumes, nonverbal intelligence (as a proxy for cognitive function), and emotional or behavioral problems in children.…”

mentioning

confidence: 99%

Cavum Septum Pellucidum in the General Pediatric Population and Its Relation to Surrounding Brain Structure Volumes, Cognitive Function, and Emotional or Behavioral Problems

Dremmen¹,

Bouhuis²,

Blanken

et al. 2019

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: The cavum septum pellucidum, a cavity filled with CSF, is localized between the 2 lateral ventricles of the brain. The cavum is present in all neonates, but it typically closes within 5 months after birth. In some cases, this closure does not occur and a persistent or enlarged cavum septum pellucidum has been linked, in some studies, to psychiatric disorders. However, the clinical relevance in the general population is unknown. In this study, we examined the relationship between the cavum septum pellucidum and volumes of brain structures, cognitive function, and emotional and behavioral problems in children. MATERIALS AND METHODS: This study was embedded in the Generation R Study, a prospective cohort in Rotterdam, the Netherlands. MR imaging studies of 1070 children, 6-10 years of age, were systematically evaluated for the presence and length of a persistent cavum septum pellucidum. An enlarged cavum septum pellucidum was defined as a cavum length of Ն6 mm. Groups without, with persistent, and with enlarged cavum septi pellucidi were compared for brain structure volumes, nonverbal intelligence, and emotional and behavioral problems. RESULTS: The prevalence of cavum septi pellucidi in our sample was 4.6%. Children with an enlarged cavum septum pellucidum had a larger corpus callosum, greater thalamic and total white matter-to-total brain volume ratio, and smaller lateral ventricle volumes. We did not find a relationship between cavum septi pellucidi and cognitive function or emotional and behavioral problems. CONCLUSIONS: The cavum septum pellucidum is a normal structural brain variation without clinical implications in this population-based sample of school-aged children. ABBREVIATIONS: CBCL ϭ Child Behavior Checklist; CSP ϭ cavum septum pellucidum; IQ ϭ intelligence quotient; M ϭ marginal mean; s ϭ Spearman partial correlation; SE ϭ standard error

show abstract

“…We suggest that the symptoms in the present case may be attributed to HFI, however, future studies are needed to validate this hypothesis. Headache, bipolar disorder, and other psychiatric symptomology have been correlated with the presence of cavum septi pellucidi and cavum vergae (Nopoulos et al, 2000;Crippa et al, 2004;Filipovic et al, 2004a,b;Varsik et al, 2005). Both of these cavities, usually gone by adulthood, were present in this adult donor.…”

Section: Discussionmentioning

confidence: 99%

A case of extensive hyperostosis frontalis interna in an 87‐year‐old female human cadaver

2008

View full text Add to dashboard Cite

Hyperostosis frontalis interna (HFI) is a condition that involves thickening of the inner surface of the frontal bone with sparing of the midline. Little is known about the etiology and clinical presentation of HFI. We report unusual findings in a woman with extensive Type D hyperostosis of the frontal bone and a large hyperostotic nodule in the parietal bone with impingement on the precentral gyrus, distinguishing this from the common form of HFI. The scalp was dissected from the cranial vault, and the calvaria and brain were removed and digitally imaged. Bone specimens were embedded in methyl methacrylate plastic, sectioned, and stained using the Von Kossa Method with MacNeal's tetrachrome. Medical records were reviewed, and additional history was obtained through interviews with the donor's family. The calvaria had extensive, bilateral thickening of the frontal bone with irregular topography and clearly demarcated borders. The dura was adherent to all hyperostotic regions. A 3.5-cm nodule was visible on the inner table of the left parietal bone. The dura and cerebrum showed compression in this region, but it was unclear if this resulted in clinical ramifications. Microscopic analysis revealed a larger proportion of cancellous bone was present in regions of macroscopic hyperostosis. Quantitative analysis of sections through areas of gross hyperostosis demonstrated a lower proportion of lamellar bone than in the control. The patient exhibited symptoms that have been correlated to HFI in previous studies. We suggest that the HFI disease process was responsible for the manifestation of these symptoms in this patient.

show abstract

The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder

Cited by 14 publications

References 11 publications

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Cavum Septum Pellucidum in the General Pediatric Population and Its Relation to Surrounding Brain Structure Volumes, Cognitive Function, and Emotional or Behavioral Problems

A case of extensive hyperostosis frontalis interna in an 87‐year‐old female human cadaver

Contact Info

Product

Resources

About