Modulation of hormone secretion by functional electrical stimulation of the intact and incompletely dysfunctional dog pancreas

Rozman, Janez; Bunc, M.; Zorko, B.

doi:10.1590/s0100-879x2004000300012

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…Insulin is normally secreted from the pancreatic islets, and the release of endogenous insulin is under the influence of circulating nutrients and various neural factors, including vagal and parasympathetic pathways [18]. It has been reported that vagal nerve stimulation can significantly increase insulin secretion for a prolonged period of time in intact and in partly dysfunctional pancreas, while splanchnic nerve (sympathetic) stimulation can reduce insulin secretion [19,20]. The lower levels of plasma insulin observed in this study may be associated with the activation of sympathetic pathways, as we have recently found that electrical stimulation indeed can activate α-and β-adrenergic pathways in the stomach [1].…”

Section: Discussionmentioning

confidence: 99%

“…Ghrelin and leptin are both expressed abundantly in stomach and are secreted into the gastric lumen and the circulatory system once stimulated [10,11,[14][15][16][17]. Endocrine secretion of insulin from pancreas is under the influence of various neural pathways [18][19][20]. All Modified IGS parameters are similar to those for IGS, except that the pulse width was increased from 0.3 to 2 msec these peptides are released during eating and may function in the short-term system control of feeding behavior.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

et al. 2007

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This study evaluated the effect of gastric electrical stimulation (GES) with various parameters on plasma concentrations of satiety-related peptides and glucose. GES was performed in nine healthy dogs via electrodes implanted in the middle of the lesser curvature. Four sessions were performed in each animal: control, stimulation with IGS (implantable gastric stimulation for obesity, 0.3 m sec), modified IGS (2 msec), and long pulses (300 msec). Blood samples were collected at 15 and 0 min before the meal and at 15, 30, and 60 min after the meal. GES was initiated 30 min before the first blood sample and maintained throughout collection. Plasma ghrelin, leptin, insulin and glucose were measured. The total AUCs of plasma ghrelin and leptin were not significantly affected by GES. The total AUC of plasma insulin was significantly lower with IGS and long pulse parameters (P < 0.05). The total AUC for plasma glucose was significantly lower in sessions with long pulses and modified IGS parameters (P < 0.05). We conclude that acute GES is able to change the release of some satiety-related peptides. Whether this is associated with the changed eating behavior and weight loss in obese patients needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

et al. 2007

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“…Greater nutrient availability can, in turn, increase IGF-1 levels (Thissen, Ketelslegers & Underwood, 1994). Vagal stimulation also promotes the release of insulin (Rozman, Bunc & Zorko, 2004), and insulin has been shown to stimulate the synthesis and release of IGF-1 (Kalme, Loukovaara, Koistinen, Koistinen, Seppala & Leinonen, 2001; Thissen et al, 1994). The stimulation of pressure receptors can also promote the release of insulin (Marchini, Lagercrantz, Feuerberg, Winberg, Uvnas-Moberg, 1987).…”

Section: Moderate Pressure Is Criticalmentioning

confidence: 99%

Preterm infant massage therapy research: A review

Field¹,

Diego²,

Hernandez‐Reif³

2010

Infant Behavior and Development

210

144

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In this paper, preterm infant massage therapy studies are reviewed. Massage therapy has led to weight gain in preterm infants when moderate pressure massage was provided. In studies on passive movement of the limbs, preterm infants also gained significantly more weight, and their bone density also increased. Research on ways of delivering the massage is also explored including using mothers versus therapists and the added effects of using oils. The use of mothers as therapists was effective in at least one study. The use of oils including coconut oil and safflower oil enhanced the average weight gain, and the transcutaneous absorption of oil also increased triglycerides. In addition, the use of synthetic oil increased vagal activity, which may indirectly contribute to weight gain. The weight gain was associated with shorter hospital stays and, thereby, significant hospital cost savings. Despite these benefits, preterm infant massage is only practiced in 38% of neonatal intensive care units. This may relate to the underlying mechanisms not being well understood. The increases noted in vagal activity, gastric motility, insulin and IGF-1 levels following moderate pressure massage are potential underlying mechanisms. However, those variables combined do not explain all of the variance in weight gain, highlighting the need for additional mechanism studies.

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“…insulin) and digestive hormones (i.e. gastrin) (Chang et al, 2003' Rozman, Bunc & Zorko, 2004. Further, tactile stimulation promotes the release of both food absorption (insulin) and digestive hormones (Marchini, Lagercrantz, Feuerberg, Winberg & Uvnas-Moberg, 1987;Uvnas-Moberg, 2004).…”

Section: Vagal Stimulation For Preterm Infantsmentioning

confidence: 99%

Vagal activity, early growth and emotional development

Field

Diego

2008

Infant Behavior and Development

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A review of the research on infant vagal tone suggests that vagal activity is associated with both infant growth and infant socioemotional development. Vagal activity has been noted to increase following the stimulation of pressure receptors as in massage therapy. Vagal activity, in turn, stimulates gastric motility which mediates weight gain in infants. Vagal activity has also been notably elevated during synchronous mother-infant interactions and positive affect, providing confirmatory data for the Porges "Social Engagement System" model. In contrast, low vagal activity has been noted in prenatally depressed mothers (and prenatally angry and anxious mothers) and their infants, as well as in children with autism. These studies highlight the relations between vagal activity and the social behaviors of attentiveness, facial expressions and vocalizations.The vagus nerve is a key component in the regulation of the autonomic nervous system and socioemotional function. It is composed of afferent (sensory) and efferent (motor) fibers that innervate most organs in the body including the gastrointestinal and cardiovascular systems as well as the ears, mouth and voice (Chang, Mashimo & Goyal, 2003; Kandel, Schwartz & Jessel, 2000). Heart rate variability has been used to estimate vagal activity and serves as a noninvasive measure of autonomic nervous system function and maturation that has been shown to reflect vagal regulation of the heart and the gastro-intestinal system (Fox & Porges, 1985; Katoh, Nomura, Iga, Hiasa, Uehara, Harada et al., 2003; Task Electrophysiology, 1996). Several time and frequency domain methods have been used to estimate vagal activity from heart rate variability, yielding comparable results and include the Bohrer and Porges (1982) algorithm to estimate vagal tone, Lorenz plots on interbeat intervals to estimate the Toichi Cardiac Vagal Index (CVI), and spectral analyses to estimate the high frequency component of heart rate variability (HF, RSA) (Allen Chambers, Towers, 2006; Task Force of the European Society of Cardiology, and the North American Society of Pacing and Electrophysiology, 1996).Estimates of vagal activity from heart rate variability have been widely used in studies assessing infant development, affect and social interactions. In these studies, vagal tone, specifically baseline vagal tone has been variously treated as a correlate, a predictor, a mediator, a marker variable and even a causal variable of normal and abnormal behaviors and conditions. The primary theme of the review paper is that baseline vagal activity may be considered a stable physiological state just as expressivity has been considered a primary behavior component of individual infant temperament. Secondly, low baseline vagal activity appears to be a marker of infant risk conditions such as prematurity and depression. Third, vagal stimulation in the Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providi...

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Modulation of hormone secretion by functional electrical stimulation of the intact and incompletely dysfunctional dog pancreas

Cited by 9 publications

References 20 publications

Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

Effect of Acute Gastric Electrical Stimulation on the Systemic Release of Hormones and Plasma Glucose in Dogs

Preterm infant massage therapy research: A review

Vagal activity, early growth and emotional development

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