Acute leukemias in Piauí: comparison with features observed in other regions of Brazil

Abstract

Differences in age and sex distribution as well as FAB (FrenchAmerican-British classification) types have been reported for acute leukemias in several countries. We studied the demographics and response to treatment of patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) between 1989 and 2000 in Teresina, Piauí, and compared these results with reports from Brazil and other countries. Complete data concerning 345 patients (230 ALL, 115 AML) were reviewed. AML occurred predominantly in adults (77%), with a median age of 34 years, similar to that found in the southeast of Brazil but lower than the median age in the United States and Europe (52 years). FAB distribution was similar in children and adults and FAB-M2 was the most common type, as also found in Japan. The high frequency of FAB-M3 described in most Brazilian studies and for Hispanics in the United States was not observed. Overall survival for adults was 40%, similar to other studies in Brazil. A high mortality rate was observed during induction. No clinical or hematological parameter influenced survival in the Cox model. ALL presented the characteristic peak of incidence between 2-8 years. Most of the cases were CD10+ pre-B ALL. In 25%, abnormal expression of myeloid antigens was observed. Only 10% of the patients were older than 30 years. Overall survival was better for children. Age and leukocyte count were independent prognostic factors. These data demonstrate that, although there are regional peculiarities, the application of standardized treatments and good supportive care make it possible to achieve results observed in other countries for the same chemotherapy protocols.

Flowcytometric Immunophenotypic Profile of Acute Leukemia: Mansoura Experience

“…As regard ALL, there were 38 cases (74.5%) with B-ALL and 13 cases (25.5%) with T-ALL. These results were in concordance with the most published data [6,12,13]. Common ALL (CD10 positive) accounted for 89.5% of B-ALL cases which is concomitant with Rego et al and Gujral et al [6,13].…”

“…Most of the previous studies reported lower APL percentages ranging from 5 to 14% of all AML cases [7][8][9][10][11] while fewer investigators stated nearly similar percentage to our results (24%) [4,5]. Rego et al [6] found completely different percentages of APL in two different cities within Table 3 Lineage demarcation markers expression in acute leukemia Brazil (7.8 and 21% of AML). Most published data indicated the predominance of M1-2 as the most common AML subtypes [5,[9][10][11].…”

“…The high percentage of AML may be due to the large number of adults involved in our study (65.8%). The FAB distribution of AML has been extensively studied by many researchers allover the world [4][5][6][7][8][9][10][11]. In our study, APL accounted for 23%, while non-APL AML accounted for 77% of all AML cases.…”

Tratamiento de la leucemia linfoide aguda del adulto: Experiencia de un hospital en la Ciudad de México

“…Su incidencia en México es 5 casos por 100.000 habitantes 2 . La supervivencia en diversas regiones de Latinoamérica oscila entre 24 y 41% a 5 años [3][4][5] . En nuestro país, Arteaga y cols en el Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ) han descrito los resultados del protocolo institucional 0195 con una tasa de remisiones completas (RC) del 74% y una supervivencia global en promedio de 15 meses 6 .…”

Characterization and analysis of the outcome of adults with acute myeloid leukemia treated in a Brazilian University hospital over three decades

“…However, while randomized clinical trials have reported high long-term survival rates, the results of population-based studies have shown long-term remissions in a quarter of patients only (4)(5)(6)(7). Furthermore, retrospective studies performed in developing countries have reported even lower overall survival rates (8)(9)(10)(11)(12)(13).…”