Cell migration in the postnatal subventricular zone

Menezes, João R.L.; Marins, Monica; Alves, José A. J.; Fróes, Maira Monteiro; Hedin-Pereira, Cecília

doi:10.1590/s0100-879x2002001200002

Cited by 30 publications

(22 citation statements)

References 68 publications

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“…The migration of olfactory interneuron precursors from the SVZ toward the OB is a highly regulated process influenced by different factors, including soluble molecules with attractive or repulsive functions as well as cell adhesion and extracellular matrix molecules (Ono et al, 1994;Hu et al, 1996;Wu et al, 1999;Conover et al, 2000;Menezes et al, 2002). In this report, we provided evidence that HGF and its receptor Met are likely to be involved in this process.…”

Section: Discussionmentioning

confidence: 71%

Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling

Garzotto¹,

Giacobini²,

Crepaldi³

et al. 2008

Journal of Neuroscience

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The olfactory bulb is one of the few structures in the mammalian forebrain in which continuous neurogenesis takes place throughout life. Neuronal precursors originate from progenitors located in the subventricular zone (SVZ) of the lateral ventricles, move tangentially in chains through the rostral migratory stream (RMS), and reach the olfactory bulb (OB), where they finally differentiate into granule and glomerular interneurons. Multiple molecular factors are involved in controlling the various steps of this neurogenic process. Here, we show that hepatocyte growth factor (HGF) and its receptor Met protein are expressed in vivo in the OB and throughout the migratory pathway, implying that HGF might mediate migratory signals in this system. By using primary in vitro cultures, we demonstrate that HGF promotes migration of RMS neuroblasts, acting both as an inducer and attractant. HGF stimulation on RMS tissue explants selectively induces MAP kinase pathway activation. Furthermore, in vitro analysis of mice with a point mutation in the Met receptor that impairs signal transduction through the Ras/MAP kinase pathway (Met Grb2/Grb2 ) shows that without Met-Grb2 binding, neuroblast migration is reduced. Overall, these findings indicate that HGF signaling via Met-Grb2 coupling influences olfactory interneuron precursor migration along the RMS.

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Section: Discussionmentioning

confidence: 71%

Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling

Garzotto¹,

Giacobini²,

Crepaldi³

et al. 2008

Journal of Neuroscience

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“…A population of cells that has been described as highly motile and implicated in migrational events are cells from the neural stem cell lineage (Doetsch et al, 1997;Gage et al, 1998;Alvarez-Buylla et al, 2000;Menezes et al, 2002;Suzuki and Goldman, 2003). The SVZ is by far the largest germinal region in the adult mammalian brain and located along the length of the lateral ventricles (Morshead et al, 1994;Steindler et al, 1996;Doetsch et al, 1997;Sanai et al, 2004).…”

Section: In the Subventricular And Subgranular Zone Gfap-d Marks Thementioning

confidence: 99%

Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton

Roelofs

Fischer

Houtman

et al. 2005

Glia

141

218

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Human glial fibrillary acidic protein-delta (GFAP-delta) is a GFAP protein isoform that is encoded by an alternative splice variant of the GFAP-gene. As a result, GFAP-delta protein differs from the predominant splice form, GFAP-alpha, by its C-terminal protein sequence. In this study, we show that GFAP-delta protein is not expressed by all GFAP-expressing astrocytes but specifically by a subpopulation located in the subpial zone of the cerebral cortex, the subgranular zone of the hippocampus, and, most intensely, by a ribbon of astrocytes following the ependymal layer of the cerebral ventricles. Therefore, at least in the sub ventricular zone (SVZ), GFAP-delta specifically marks the population of astrocytes that contain the neural stem cells in the adult human brain. Interestingly, the SVZ astrocytes actively splice GFAP-delta transcripts, in contrast to astrocytes adjacent to this layer. Furthermore, we show that GFAP-delta protein, unlike GFAP-alpha, is not upregulated in astrogliosis. Our data therefore indicate a different functional role for GFAP-delta in astrocyte physiology. Finally, transfection studies showed that GFAP-delta protein expression has a negative effect on GFAP filament formation, and therefore could be important for modulating intermediate filament cytoskeletal properties, possibly facilitating astrocyte motility. Further studies on GFAP-delta and the cells that express it are important for gaining insights into its function during differentiation, migration and during health and disease.

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“…In the adult, the new neurons generated in this region enter the rostral migratory stream, complete their last divisions, and continue to migrate into the olfactory bulb where they differentiate into new neurons (21,22). In the hippocampal formation, progenitor cells divide along the border between the hilus and the granule cell layer, and daughter cells differentiate into granule cell neurons (23).…”

Section: Neurogenesis In the Adult Mammalian Brainmentioning

confidence: 99%

Regulation and function of neurogenesis in the adult vertebrate brain

Mendez-Otero

Zaverucha-do-Valle

Gubert

et al. 2005

Braz J Med Biol Res

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Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has changed the way we think about neurological diseases and about the exploration of new strategies for brain repair. In this review we will explore the potential of adult neural stem cells and we will present some of our own work on this subject. We will also discuss the possibility that adult neurogenesis and neuronal replacement may also play a role in therapies aimed at restoring impaired brain function. A better understanding of the various aspects of spontaneous neuronal replacement may also be used to increase the success of procedures with cell therapies.

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Cell migration in the postnatal subventricular zone

Cited by 30 publications

References 68 publications

Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling

Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling

Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton

Regulation and function of neurogenesis in the adult vertebrate brain

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