Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats

Abstract

Idarubicin is an anthracycline antibiotic extensively used in acute leukemia. In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of idarubicin. Vitamin E (200 IU kg -1 week -1 ), catechin (200 mg kg -1 week -1 ), idarubicin (5 mg kg -1 week -1 ), idarubicin + vitamin E (200 IU kg -1 week -1 ), and idarubicin + catechin (200 mg kg -1 week -1 ) combinations were given to male Sprague-Dawley rats weighing 210 to 230 g (N = 6/group). Idarubicintreated animals exhibited a decrease in body and heart weight, a decrease in myocardial contractility, and changes in ECG parameters (P<0.01). Catechin + idarubicin-and vitamin E + idarubicin-treated groups exhibited similar alterations, but changes were attenuated in comparison to those in cardiac muscle of idarubicin-treated rats (P<0.05). Superoxide dismutase and catalase activity was reduced in the idarubicin-treated group (P<0.05). Glutathione peroxidase levels were decreased in the idarubicin-treated group (P<0.05) and reached maximum concentrations in the catechin-and catechin + idarubicintreated groups compared to control (P<0.01). Malondialdehyde activity was decreased in the catechin + idarubicin-treated groups compared to control and increased in the other groups, reaching maximum concentrations in the vitamin E-treated group (P<0.01). In electron microscopy studies, swelling of the mitochondria and dilatation of the sarcoplasmic reticulum of myocytes were observed in the idarubicintreated groups. In groups that were given idarubicin + vitamin E and idarubicin + catechin, the only morphological change was a weak dilatation of the sarcoplasmic reticulum. We conclude that catechin and vitamin E significantly reduce idarubicin-induced cardiotoxicity in rats.

Phyto-phospholipid complex of catechin in value added herbal drug delivery

“…Catechins (the examples include catechin, epicatechin, epigallocatechin, gallocatechin, epigallocatechin gallate etc.) are poorly absorbed through the gastrointestinal and [1,2]. Heating catechins past their point of decomposition release pyrocatechol, which explains the common origin of the names of these compounds.…”

“…It was showed that catechin significantly reduced Idarubicin induced carditoxicity in rats [1]. Takano et al studied the protective effect of (?…”

Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats

“…Several reports suggest that oxygen-free radicals produced during the metabolic activation of DXR may have toxic effects on heart muscle (Kozluca et al, 1995;Kalender et al, 2001), which is provided with poor mechanisms of detoxification of such species (Doroshow et al, 1980;Rajagopalan et al, 1988). It was mentioned that DXR has toxic effects on liver (Bagchi et al, 1995).…”

The protection of the myocardium by amifostine against mitoxantrone-induced acute cardiotoxicity in rats

“…Catalase, SOD and Gpx play critical roles in protecting the myocardium from lipid peroxidation and free oxygen radicals under oxidative damage. It was detected in some experimental studies that doxorubicin and idarubicin decreased GSH, catalase, Gpx, and SOD levels in the heart tissue [9,11,37,38]. However, over-expression of catalase and Mn-SOD activities were detected after doxorubicin administration.…”