Genetic characterization of dengue virus type 3 isolates in the State of Rio de Janeiro, 2001

Miagostovich, Marize Pereira; Santos, Flávia Barreto dos; Simone, Thatiane Santos De; Costa, Eliane Veiga da; Filippis, Ana María Bispo de; Schatzmayr, Hermann G.; Nogueira, Rita Maria Ribeiro

doi:10.1590/s0100-879x2002000800002

Cited by 43 publications

(31 citation statements)

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“…8,[14][15][16] In 1999 and 2000, DENV-3 was detected in Ecuador, Venezuela, and Brazil and later in other South American countries. [17][18][19] The molecular evolution of DENV-3 has been studied in numerous American countries, including Nicaragua, Venezuela, Mexico, Brazil, Paraguay, Cuba, Peru, and Argentina. [16][17][18][20][21][22][23][24] All of these studies point to subtype III as the only DENV-3 circulating in the Western Hemisphere.…”

Section: Introductionmentioning

confidence: 99%

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Ospina¹,

Díaz²,

Osorio³

2010

The American Journal of Tropical Medicine and Hygiene

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Section: Introductionmentioning

confidence: 99%

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Ospina¹,

Díaz²,

Osorio³

2010

The American Journal of Tropical Medicine and Hygiene

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“…From 1995 to 2001, an increasing number of DF and DHF cases has been observed in several urban areas of the country (17). Recently, DEN-3 has been isolated in Brazil but its association with DHF has not been clearly established (27,28).…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001

Neto

Lima

Paula

et al. 2005

Braz J Med Biol Res

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“…In most cases, hepatic involvement prolongs the clinical course of this self-limiting viral infection, but it does not constitute a sign of worse prognosis. [8][9][10][11][12][13][14] The present study was conducted with the primary objective of studying the serum transaminases level in various forms of dengue infection and correlate with the severity and outcome of the disease at a tertiary care hospital.…”

mentioning

confidence: 99%

Profile of serum transaminases in patients with dengue infection in a tertiary care hospital

Kulkarni

Koppad

Shetty

2017

Int J Contemp Pediatr

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INTRODUCTIONDengue ranks among the most important mosquito-borne viral disease in the world. Dengue fever is an acute infectious disease caused by an arbovirus in the Flavivirus genus. It has four serotypes, and the mosquito Aedes aegypti is the vector. While dengue is a global concern, currently close to 75% of the global population exposed to dengue are in the Asia-Pacific region.Dengue virus was isolated in India for the first time in 1945. Over the last few years, atypical manifestations of ABSTRACT Background: Although dengue virus is a non hepatotropic virus, liver injury due to dengue infection is not uncommon. Atypical manifestations with liver involvement have frequently been reported, ranging from mild elevations of aminotransferase levels to fulminant hepatitis. The aim of the present study is to study the serum transaminases level in various forms of dengue infection and correlate with severity. Methods: An analysis of 151 serologically confirmed cases (0-14 yrs) of dengue from June 2017 to July 2017 at a tertiary care hospital, Dharwad was made to assess the frequency and degree of hepatic dysfunction in children with dengue infection by analyzing serum transaminase levels. Patients were classified according to WHO as dengue without warning signs, with warning signs and severe dengue. Patients were divided into primary and secondary dengue based on serology and serum transaminases levels were assessed in each of the above groups. Patients with normal aminotransferase levels were categorized into Grade A, those with atleast one of the enzymes raised to less than 3 times the reference range as Grade B, those with atleast one of the enzymes elevated more than 3 times but less than 10 times as Grade C and those with elevations more than 10 times as Grade D. χ2 test was applied to check statistical significance. Results: During the study period, the total number of serologically confirmed cases of dengue were 151 among which dengue fever without warning signs were 38, with warning signs were 91 and severe dengue were 22. Serum transaminase levels were significantly raised in severe dengue (χ2=14.228, df=6, p=0.027).It was also found that transaminases were significantly higher in secondary dengue infection than primary dengue ( χ2=10.155, df=3, p=0.017). Transaminases were significantly elevated in non-survivors (χ2=16.958, df=3, p<0.001). Conclusions: Hepatic dysfunction was common in all forms of dengue infection, with AST rising significantly more than ALT. Transaminases were significantly elevated in severe dengue and secondary dengue infections. Patients with significantly high transaminases had a poor outcome.

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Genetic characterization of dengue virus type 3 isolates in the State of Rio de Janeiro, 2001

Cited by 43 publications

References 12 publications

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001

Profile of serum transaminases in patients with dengue infection in a tertiary care hospital

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