M Me ek ko on ny yu um m i il le eu us su un nu un n 1 12 2 a ay y a al lt t› ›n nd da a t ta an n› › a al la an n k ki is st ti ik k f fi ib br ro oz zl lu u h ha as st ta al la ar rd da a k kl li in ni ik k s se ey yi ir re e e et tk ki is si i E Ef ff fe ec ct t o of f m me ec co on ni iu um m i il le eu us s o on n t th he e c cl li in ni ic ca al l p pr ro og gn no os si is s o of f p pa at ti ie en nt ts s w wi it th h c cy ys st ti ic c f fi ib br ro os si is s d di ia ag gn no os se ed d a at t y yo ou un ng ge er r t th ha an n 1 12 2 m mo on nt th hs s S Se ev vg gi i P Pe ek kc ca an n, , N Nu ur ra al l K Ki ip pe er r* *, , M Me eh hm me et t K Kö ös se e* ** *, , A Ay yfl fle e T Ta an na a A As sl la an n* ** ** *, , N Na az za an n Ç Ço ob ba an no o¤ ¤l lu u* *, , E Eb br ru u Y Ya al lç ç› ›n n* *, , D De en ni iz z D Do o¤ ¤r ru u* *, , U U¤ ¤u ur r Ö Öz zç çe el li ik k* * Ö Öz zg gü ün n A Ar ra afl flt t› ›r rm ma a O Or ri ig gi in na al l A Ar rt ti ic cl le e Ö Öz ze et t Amaç: Mekonyum ileusu kistik fibrozda %10-20 oran›nda görülür. ‹lk tan› bulgular›ndan biridir. On iki ay alt›nda tan› alan kistik fibrozlularda mekonyum ileusu varl›¤›n›n seyire etkisini mekonyum ileusu olmayan grup ile karfl›laflt›rmak.
Material and Method:The sample consisted of 214 patients with CF diagnosed at younger than 12 months admitted to the pediatric pulmonology unit over a period of 18 years between January 1987 to December 2005. 22 patients presented with MI (MI group), 192 patients had non MI (nonMI group). Demographic, clinical, nutritional and laboratory data were obtained.Results: There were 11 female, 11 male patients in MI group, 85 female and 107 male patients in nonMI group. A statistically significant difference was not observed between the groups studied regarding the following variables: BMI, Staphylococcus aureus and Pseudomonas aeruginosa colonisations, mutation types, respiratory functions assesed by FEV1, lung findings. Pseudo-Bartter's syndrome and progression to bronchiectasis were detected higher in nonMI group statistically.
Conclusions:There is no prognostic difference between two groups when these patients are diagnosed early and followed-up by a multidisciplinary action and a collective treatment approach. The results of the present study suggest that meconium ileus is not an indication of a more severe phenotype of cystic fibrosis. (Turk Arch Ped 2010; 45: 105-10)