Effects of terpineol on the compound action potential of the rat sciatic nerve

Moreira, Maria Rosilene Cândido; Cruz, Giovany Michely Pinto da; Lopes, Monalisa Soares; Albuquerque, A.A.C.; Leal-Cardoso, José Henrique

doi:10.1590/s0100-879x2001001000015

Cited by 43 publications

(33 citation statements)

References 8 publications

(7 reference statements)

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“…Furthermore, in agreement with the mechanism of action of EOCn, 1,8-cineole was found to act by a non-opioid mechanism (18). Methyleugenol (19) and a-terpineol (20) have been reported to be central and peripheral neural depressants, respectively, which raises the suspicion that they might act as antinociceptive agents. For the other constituents we found no report in the literature on either antinociceptive or neural activity.…”

supporting

confidence: 64%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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Croton nepetaefolius Baill. is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hotplate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.

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supporting

confidence: 64%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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“…The effects of eugenol and some of its derivatives, such as terpineol, on CAP have been investigated (4,17,18). All of these agents blocked the CAP of sciatic nerve with higher potency than demonstrated here for estragole.…”

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confidence: 91%

Effects of estragole on the compound action potential of the rat sciatic nerve

Leal-Cardoso

Matos-Brito

Lopes-Junior

et al. 2004

Braz J Med Biol Res

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Estragole, a relatively nontoxic terpenoid ether, is an important constituent of many essential oils with widespread applications in folk medicine and aromatherapy and known to have potent local anesthetic activity. We investigated the effects of estragole on the compound action potential (CAP) of the rat sciatic nerve. The experiments were carried out on sciatic nerves dissected from Wistar rats. Nerves, mounted in a moist chamber, were stimulated at a frequency of 0.2 Hz, with electric pulses of 50-100-µs duration at 10-20 V, and evoked CAP were monitored on an oscilloscope and recorded on a computer. CAP control parameters were: peakto-peak amplitude (PPA), 9.9 ± 0.55 mV (N = 15), conduction velocity, 92.2 ± 4.36 m/s (N = 15), chronaxy, 45.6 ± 3.74 µs (N = 5), and rheobase, 3.9 ± 0.78 V (N = 5). Estragole induced a dose-dependent blockade of the CAP. At 0.6 mM, estragole had no demonstrable effect. At 2.0 and 6.0 mM estragole, PPA was significantly reduced at the end of 180-min exposure of the nerve to the drug to 85.6 ± 3.96 and 13.04 ± 1.80% of control, respectively. At 4.0 mM, estragole significantly altered PPA, conduction velocity, chronaxy, and rheobase (P ≤ 0.05, ANOVA; N = 5) to 49.3 ± 6.21 and 77.7 ± 3.84, 125.9 ± 10.43 and 116.7 ± 4.59%, of control, respectively. All of these effects developed slowly and were reversible upon a 300-min wash-out. The data show that estragole dose-dependently blocks nerve excitability. Correspondence

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“…Essential oils components, such as terpineol [38], estragole [39], 1,8-cineole [40], and linalool [22], have been reported to produce effects on the CNS [41] at similar concentration ranges and in similar experimental models to those used in this study. The essential oil of Alpinia zerumbet , of which 4TRP is a major component, alters electrophysiological parameters [42].…”

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confidence: 99%

Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies

Nóbrega

Salvadori

Masson

et al. 2014

Oxidative Medicine and Cellular Longevity

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Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.

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Effects of terpineol on the compound action potential of the rat sciatic nerve

Cited by 43 publications

References 8 publications

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Effects of estragole on the compound action potential of the rat sciatic nerve

Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies

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