2001
DOI: 10.1590/s0100-879x2001000500016
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The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro

Abstract: Neurons from the anterior subventricular zone (SVZ) of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be rich in 9-O-acetyl GD3 gangliosides (9-O-acGD3), which have been previously shown to be implicated in gliophilic migration in the rodent cerebral cortex and c… Show more

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Cited by 22 publications
(24 citation statements)
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“…In these regions, cells are found with migratory profiles. The observation that labeling with Jones mAb is restricted to regions of cell migration is consistent with previous reports that have suggested that the ganglioside 9-O-acetyl GD3 is a marker for neuronal migration in the developing Schlosshauer et al, 1988;Mendez-Otero and Ramon-Cueto, 1994;Miyakoshi et al, 2001;Santiago et al, 2001) (for review, see Mendez-Otero and Santiago, 2001) and adult (Mendez-Otero and Cavalcante, 1996) nervous system. We also show that the antibody against 9-Oacetyl GD3 arrests granule cells in the external granular cell layer and diminishes the number of BrdU-positive granule cells in the internal granular cell layer by 57%.…”
Section: Discussionsupporting
confidence: 90%
“…In these regions, cells are found with migratory profiles. The observation that labeling with Jones mAb is restricted to regions of cell migration is consistent with previous reports that have suggested that the ganglioside 9-O-acetyl GD3 is a marker for neuronal migration in the developing Schlosshauer et al, 1988;Mendez-Otero and Ramon-Cueto, 1994;Miyakoshi et al, 2001;Santiago et al, 2001) (for review, see Mendez-Otero and Santiago, 2001) and adult (Mendez-Otero and Cavalcante, 1996) nervous system. We also show that the antibody against 9-Oacetyl GD3 arrests granule cells in the external granular cell layer and diminishes the number of BrdU-positive granule cells in the internal granular cell layer by 57%.…”
Section: Discussionsupporting
confidence: 90%
“…However, 9-O-acGD3 molecules were also shown to be expressed in the developing and adult SVZ/RMS labeling migratory profiles (41). Their role as possible mediators of neuroblast homophilic migration was confirmed in studies in which ganglioside 9-O-acGD3 was shown to be present in migrating chains of cells devoid of glia in postnatal SVZ explant cultures (42). Immunoblocking ganglioside 9-O-acGD3 produced a drastic decrease in the migration halo in these explants (43).…”
Section: Cell Contact-mediating Moleculesmentioning
confidence: 86%
“…Immunoblocking ganglioside 9-O-acGD3 produced a drastic decrease in the migration halo in these explants (43). One could speculate that PSA-NCAM and 9-O-acGD3 would be expressed in different subsets of the SVZ cells but in general both molecules are found in the same cells (42). Recent evidence suggests that these gangliosides might reside in focal adhesion sites together with integrins and other adhesion-mediating molecules performing a still obscure role.…”
Section: Cell Contact-mediating Moleculesmentioning
confidence: 99%
“…Neutrophil motility is sharply reduced when GM1 gangliosides are neutralized (35). Migrat- ing neurons in the developing cerebral cortex, subventricular zone, or cerebellum are also affected after immunoblockage of 9-O-acetyl GD3 ganglioside (11,13,14). Gangliosides are known to interact laterally in the membrane, regulating the responsiveness of receptors for insulin, epidermal growth factor, and vascular endothelial growth factor (36).…”
Section: Discussionmentioning
confidence: 99%