Zinc and water intake in rats: investigation of adrenergic and opiatergic central mechanisms

Fregoneze, J.B.; Luz, Carla Patrícia Novais; Castro, L.; Oliveira, Pedro Dantas; Lima, A.K.S.; Souza, F.S; Maldonado, Igor Lima; Macêdo, D.F.; Ferreira, M.G.; Bandeira, Isabelle Pastor; Rocha, Mariane Amorim; Carvalho, F.; de-Castro-e-Silva, E

doi:10.1590/s0100-879x1999001000007

Cited by 9 publications

(10 citation statements)

References 12 publications

(14 reference statements)

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“…Indeed, a result of water deprivation is change to hair coat and hair loss (57,58), and consequently, the reported drop in daily water intake might be in part responsible for anagen retardation observed by us. On the other hand, it should still be considered a direct effect of zinc, which likely acts on the hypothalamic level as an antidipsogenic factor (59) and does not lead to a systemic stress response. It is particularly difficult to assess in in vivo experiments to what extent anagen inhibition is a result of direct zinc action on HFs, and to what extent – a result of antidipsogenic action of zinc.…”

Section: Discussionmentioning

confidence: 99%

“…As the experimental animals were given zinc solution ad libitum , artificial water shortage to the level of the daily intake of zinc‐treated groups would cause the real water‐deprivation stress in control animals. Meanwhile, application of antidipsogenic factors, such as moxonidine (60) or zinc (59), can prevent water intake even in water‐deprived and dehydrated animals. It means that zinc may even cause a partial and temporal dehydration without actual water‐deprivation stress.…”

Section: Discussionmentioning

confidence: 99%

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Zinc as an ambivalent but potent modulator of murine hair growth in vivo– preliminary observations

Płonka

Handjiski

Popik

et al. 2005

Experimental Dermatology

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Oral zinc (Zn(2+)) is often employed for treating hair loss, even in the absence of zinc deficiency, although its mechanisms of action and efficacy are still obscure. In the current study, we explored the in vivo effects of oral zinc using the C57BL/6 mouse model for hair research. Specifically, we investigated whether continuous administration of high-dose ZnSO(4) x 7H(2)O (20 mg/ml) in drinking water affects hair follicle (HF) cycling, whether it retards or inhibits chemotherapy-induced alopecia (CIA) and whether it modulates the subsequent hair re-growth pattern. Here, we show that high doses of oral zinc significantly inhibit hair growth by retardation of anagen development. However, oral zinc also significantly retards and prolongs spontaneous, apoptosis-driven HF regression (catagen). Oral zinc can also retard, but not prevent, the onset of CIA in mice. Interestingly, Zn(2+) treatment of cyclophosphamide-damaged HFs also significantly accelerates the re-growth of normally pigmented hair shafts, which reflects a promotion of HF recovery. However, if given for a more extended time period, zinc actually retards hair re-growth. Thus, high-dose oral zinc is a powerful, yet ambivalent hair growth modulator in mice, whose ultimate effects on the HF greatly depend on the timing and duration of zinc administration. The current study also encourages one to explore whether oral zinc can mitigate chemotherapy-induced hair loss in humans and/or can stimulate hair re-growth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc as an ambivalent but potent modulator of murine hair growth in vivo– preliminary observations

Płonka

Handjiski

Popik

et al. 2005

Experimental Dermatology

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“…Zinc, a divalent cation with manifold biochemical and physiological functions, may play principal neuromodulatory roles in the central nervous system. Indeed, zinc is co-released with glutamate, and it modulates glutamatergic excitation by inhibiting N-methyl-D-aspartate (NMDA) receptors, and averts gammaaminobutyric acid (GABA) inhibition by blocking GABA-A receptor function [30,31] reported that zinc exerts its antioxidant property in ameliorating the effect of chlorpyrifos-induced erythrocyte fragility in Wistar rats. Neuropsychological performance has been reported to improve with Zn supplementation in young Chinese children, especially when other micronutrient nutrition is sufficient [27,28].…”

Section: Insights In Biomedicine Issn 2572-5610mentioning

confidence: 99%

Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress

Ao¹,

Ao²,

So³

et al. 2017

Insights Biomed

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“…They also showed that dehydrated rats under central cholinergic and angiotensinergic stimulation experienced antidipsogenic response to zinc treatment [25]. Further studies by this group demonstrated that zinc induced blockade of water intake in dehydrated rats may be, at least in part, due to stimulation of central opioid peptides [26].…”

Section: Reduction Of Water Intake By Zinc Acetatementioning

confidence: 99%

“…It was also shown that the inhibitory effect of zinc on water intake might be opioid-dependent. [26].…”

Section: Reduction Of Water Intake By Zinc Acetatementioning

confidence: 99%

Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms

Akomolafe¹

2014

AJLS

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This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT 3 & D 2 blocker/5HT 4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT 3 and 5HT 4 serotonergic and dopaminergic receptors.

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Zinc and water intake in rats: investigation of adrenergic and opiatergic central mechanisms

Cited by 9 publications

References 12 publications

Zinc as an ambivalent but potent modulator of murine hair growth in vivo– preliminary observations

Zinc as an ambivalent but potent modulator of murine hair growth in vivo– preliminary observations

Ameliorative Effects of Kaempferol and Zinc Gluconate on Erythrocyte Osmotic Fragility and Haematological Parameters in Wistar Rats Exposed to Noise Stress

Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms

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