Leukocyte adhesion - a fundamental process in leukocyte physiology

Abstract

Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß 2 -integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.

Protective effect of Chresta martii extract on the zymosan-induced temporomandibular joint arthritis in rats

“…1,2 Cellular migration to tissues occurs via a cascade of events. [28][29][30][31] Our results showed that CEE at 400 mg/kg reduced cellular migration of total leukocytes and MPO activity in the synovial lavage.…”

Influence of kinin peptides on monocyte-endothelial cell adhesion

“…The most important functions of leukocytes, including phagocytosis, and chemotaxis of macrophages and granulocytes, depend on adhesion of these cells to the vessel wall [Gahmberg et al, ]. Although this research area has been extensively investigated, new concepts are being constantly introduced in order to extend the knowledge of leukocyte recruitment, especially during inflammatory processes [Ley et al, ].…”

Bradykinin and des-Arg10-kallidin enhance the adhesion of polymorphonuclear leukocytes to extracellular matrix proteins and endothelial cells

“…The bars represent the mean percentage of changes in mean fl uorescence intensity (MFI) in probes vs. the control sample (assumed to be 100%) from at least 3 experiments * -a statistical signifi cance by t-Student test at p Ͻ 0.05 against the control sample of unstimulated cells. (Carlos & Harlan, 1994;Gahmberg et al, 1999). However, other cell-cell interactions have been described with a mediatory role of ECM proteins such as FBR or FBN (Carlos & Harlan, 1994;Gumbiner, 1996).…”