The role of natural killer cells in the early period of infection in murine cutaneous leishmaniasis

Laurenti, Márcia Dalastra; Gidlund, Magnus; Ura, D. M.; Sinhorini, Idércio Luiz; Corbett, Carlos Eduardo Pereira; Goto, Hiro

doi:10.1590/s0100-879x1999000300012

Cited by 18 publications

(18 citation statements)

References 7 publications

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“…Second, NK cells and myeloid cells frequently colocalize during cutaneous or visceral leishmaniasis (3,72), raising the possibility of functional interactions. Third, previous experiments involving activation, depletion, or transfer of NK cells provided evidence for a protective role of NK cells in cutaneous and visceral leishmaniasis (3,17,24,28,34,36,39,43,(56)(57)(58)61).…”

Section: Discussionmentioning

confidence: 97%

“…A series of findings argues for a protective role of NK cells in murine leishmaniasis, at least during the early phase of infection. These include (i) the aggravated course of Leishmania infections in NK cell-deficient bg/bg (beige) mice (28) or in NK cell-depleted mice (34,36,57), (ii) the disease-ameliorating effect of the activation or transfer of NK cells in Leishmania-infected mice (34,43,56), (iii) the expression of IFN-␥ by NK cells early after infection in vivo (3,17,24,39,57,58,61), and (iv) the involvement of NK cells in the protection elicited by dendritic cell (DC)-based vaccines (54). However, it should be noted that the NK cell depletions were performed only transiently prior to and early during infection using reagents (e.g., anti-NK1.1 antibody) that were not entirely selective for NK cells.…”

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confidence: 99%

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Leishmania-Infected Macrophages Are Targets of NK Cell-Derived Cytokines but Not of NK Cell Cytotoxicity

et al. 2011

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Leishmania-Infected Macrophages Are Targets of NK Cell-Derived Cytokines but Not of NK Cell Cytotoxicity

et al. 2011

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“…The direct cytotoxic role of activated NK cells on African trypanosomes remains unclear (12). Nevertheless, activated NK cells may be one of the early sources of IFN-␥ which could further activate antitrypanosome activities of M⌽s as in other infection models (15,32,36,39). In almost all protozoan diseases where NK cells have been reported to play a protective role, they seem to exert their effect through the cytokine secretory pathway rather than their direct lytic activity (12).…”

Section: Discussionmentioning

confidence: 99%

Effects of Exogenous Transforming Growth Factor β onTrypanosoma congolenseInfection in Mice

2007

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The socioeconomic implications of trypanosomosis in sub-Saharan Africa and the limitations of its current control regimes have stimulated research into alternative control methods. Considering the pro-and antiinflammatory properties of transforming growth factor ␤1 (TGF-␤1) and its potential to enhance immunity against protozoan parasites, we examined the effects of intraperitoneally delivered TGF-␤1 in C57BL/6 mice infected with Trypanosoma congolense, the hemoprotozoan parasite causing nagana in cattle. A triple dose of 10 ng TGF-␤1 significantly reduced the first parasitemic peak and delayed mortality of infected mice. Furthermore, exogenous TGF-␤1 significantly decreased the development of trypanosome-induced anemia and splenomegaly. The apparent TGF-␤1-induced antitrypanosome protection, occurring mainly during the early stage of infection, correlated with an enhanced parasite antigen-specific Th1 cell response characterized by a skewed type I cytokine response and a concomitant stronger antitrypanosome immunoglobulin G2a antibody response. Infected TGF-␤1-pretreated mice exhibited a significant reduction in the trypanosome-induced hyperexpansion of B cells. Furthermore, evidence is provided herein that exogenous TGF-␤1 activates macrophages that may contribute to parasite control. Collectively, these data indicate that exogenous TGF-␤1 is immunostimulative, inducing partial protection against T. congolense infection, possibly through mechanisms involving innate immune responses.

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“…Their presence however, may delay onset of disease as Balb/c mice lacking NK cells develop lesions faster and harbor more parasite. [37] Thus, NK cells can serve a function in control of Leishmania burden during early phases of infection through their ability to rapidly respond with IFNγ production. In vitro , human NK cells have been shown to have the ability to be directly activated to IFNγ production by Leishmania promastigotes or their LPG.…”

Section: A Recovered Role For Natural Killer (Nk) Cells In Induction mentioning

confidence: 99%

Immunological perspectives of leishmaniasis

Nylén

Gautam

2010

J Global Infect Dis

141

104

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Leishmania parasites have been widely used in experimental models to understand generation, maintenance and failure of immune responses underlying resistance and susceptibility to infection. The clinical outcomes of Leishmania infection depend on the infecting species and the immune status of the host. Noticeably most people exposed Leishmania never develop overt disease. Understanding the immunological events that result in failure or successful control of the parasites is fundamental to both design and evaluation of vaccines and therapies against the leishmaniases. Recent studies visualizing immune response to Leishmania major in the skin have given new insights into the different immune cells acting as hosts the parasite during different stage of infection. Control of Leishmania infection and disease progression has been associated with generation of T-helper (Th) 1 and Th2 responses respectively. Though still valid in several aspects, the Th1/Th2 paradigm is an oversimplification in need of revision. Th2 polarization has never explained severity of human leishmanial disease and a number of other T-cell subsets, including regulatory T- and Th17- cells, have important roles in susceptibility and resistance of both experimental and human leishmanial disease. This review gives an updated overview of immunological response considered to be of importance in protection, susceptibility, disease progression and cure of leishmaniasis, with a special emphasis on human diseases.

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The role of natural killer cells in the early period of infection in murine cutaneous leishmaniasis

Cited by 18 publications

References 7 publications

Leishmania-Infected Macrophages Are Targets of NK Cell-Derived Cytokines but Not of NK Cell Cytotoxicity

Leishmania-Infected Macrophages Are Targets of NK Cell-Derived Cytokines but Not of NK Cell Cytotoxicity

Effects of Exogenous Transforming Growth Factor β onTrypanosoma congolenseInfection in Mice

Immunological perspectives of leishmaniasis

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