Liposomes: from biophysics to the design of peptide vaccines

Frézard, Frédéric

doi:10.1590/s0100-879x1999000200006

Cited by 110 publications

(75 citation statements)

References 26 publications

(29 reference statements)

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“…The lipid bilayer has the tendency to allow a given substance to pass across it-the so-called selective permeability [32]. This means that the internal environment of a liposome can become different from the outer space.…”

Section: Liposome Propertiesmentioning

confidence: 99%

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Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

293

195

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Liposome Propertiesmentioning

confidence: 99%

“…Additionally, longer tail lipids have more area to interact [31,35,38]. Conversely, unsaturated lipids have a significantly lower T c than saturated lipids [32].…”

Section: Liposome Propertiesmentioning

confidence: 99%

Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

293

195

View full text Add to dashboard Cite

show abstract

“…When these lipids, e.g., phosphatidylcholine, phosphatidyl ethanolamine or phosphatidyl glycerol, are exposed to an aqueous environment, interactions between themselves (hydrophilic interactions between polar head groups and van der Waals interactions between hydrocarbon chains and hydrogen bonding with water molecules) lead to spontaneous formation of closed bilayers. 6 Liposomes can differ in size, ranging from the smallest vesicle (diameter 20nm) to liposomes that are visible under the light microscope, with a diameter of 1μm or greater, equal to the dimensions of living cells. 6 Liposome can carry drugs in one or three potential compartments (water soluble agents in the central aqueous core, lipid soluble agents in the membrane, peptide and small proteins at the lipid aqueous interface).…”

Section: Introductionmentioning

confidence: 99%

“…6 Liposomes can differ in size, ranging from the smallest vesicle (diameter 20nm) to liposomes that are visible under the light microscope, with a diameter of 1μm or greater, equal to the dimensions of living cells. 6 Liposome can carry drugs in one or three potential compartments (water soluble agents in the central aqueous core, lipid soluble agents in the membrane, peptide and small proteins at the lipid aqueous interface). They are classified structurally into multilamellar vesicles (MLVs) and unilamellar vesicles (ULVs).…”

Section: Introductionmentioning

confidence: 99%

Effect of cholesterol concentration on size of liposome

Pathak¹,

Mishra²,

Kumar³

et al. 2012

IOSJPBS

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“…When these lipids, e.g., phosphatidylcholine, phosphatidyl ethanolamine or phosphatidyl glycerol, are exposed to an aqueous environment, interactions between themselves (hydrophilic interactions between polar head groups and van der Waals interactions between hydrocarbon chains and hydrogen bonding with water molecules) lead to spontaneous formation of closed bilayers. 6 Liposomes can differ in size, ranging from the smallest vesicle (diameter 20nm) to liposomes that are visible under the light microscope, with a diameter of 1µm or greater, equal to the dimensions of living cells. 6 Liposome can carry drugs in one or three potential compartments (water soluble agents in the central aqueous core, lipid soluble agents in the membrane, peptide and small proteins at the lipid aqueous interface).…”

Section: Introductionmentioning

confidence: 99%

Current trends in the production and biomedical applications of liposomes: a review

Uhumwangho¹,

Okor²

2009

Journal of Medicine and Biomedical Research

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A review of literature was carried out to determine methods of production of liposomes, their stability, biodistribution and their uses as drug delivery systems. The conventional method of preparing liposomes is basically for the multilamellar vesicles (MLVs). However, other methods are used to reduce the size of these MLVs to small unilamellar vesicles (SUVs) so as to increase their plasma lifetime and consequently increase the possibility of achieving greater tissue localisation. Some of these methods of size reduction are sonication and high pressure extrusion. Each of these methods has its own advantages and disadvantages. Large unilamellar vesicles (LUVs), on the other hand, are prepared mainly by detergent removal method and reverse phase extrusion technique. There are also improved pharmacokinetic properties with liposomal drugs compared to free drugs, though some formulation factors affect the release kinetics of the liposomal drugs. The review also shows that liposomes have a lot of biomedical applications and uses. They have been used in drug targeting, oral delivery of vaccines, insulins, peptides and some compounds, which are usually degraded in the gastrointestinal tract. It has also found application in topical therapy especially in the eye and lungs. Other areas of application are in cancer chemotherapy and treatment of human immunovirus (HIV) infection. The control of the stability of liposomes is an essential prerequisite for effective use as drug carriers. Leakage of the liposome is attributable mainly to differences in lamellar structure. For instance, MLVs are less prone to leakage than ULVs. The use of a combination of saturated phospholipid and cholesterol in the formulation of the liposomes has also been found to enhance stability with lower tendency to leakage.

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Liposomes: from biophysics to the design of peptide vaccines

Cited by 110 publications

References 26 publications

Liposomes in tissue engineering and regenerative medicine

Liposomes in tissue engineering and regenerative medicine

Effect of cholesterol concentration on size of liposome

Current trends in the production and biomedical applications of liposomes: a review

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