IFN-&lt;FONT FACE=Symbol&gt;g&lt;/font&gt; in human Chagas' disease: protection or pathology?

Bahia-Oliveira, Lilian M. G.; Gomes, Juliana de Assis Silva; Rocha, Manoel Otávio Costa; Moreira, M.C.V.; Lemos, Elenice Moreira; Luz, Zélia Maria Profeta da; Pereira, M. E. S.; Coffman, R. L.; Dias, João Carlos Pinto; Cançado, J. R.; Gazzinelli, Giovanni; Corrêa-Oliveira, Rodrigo

doi:10.1590/s0100-879x1998000100017

Cited by 69 publications

(67 citation statements)

References 16 publications

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“…Although the present results showed no differences between IL-10 and IFN-γ levels in CARD and IND patients, the IND patients displayed a positive correlation between inflammatory and regulatory cytokine production, indicating a controlled immune response. These findings are supported by the higher production of IFN-γ and TNF-α associated with high IL-10 levels described in IND patients, while CARD patients showed an unregulated Th1 response (Bahia-Oliveira et al 1998, Correa-Oliveira et al 1999, Ribeirao et al 2000, Abel et al 2001, Gomes et al 2005. A lack of co-regulation between inflammatory and anti-inflammatory cytokines associated with severe disease was also demonstrated in human patients with leishmaniasis (Gaze et al 2006), strengthening this hypothesis.…”

Section: Discussionsupporting

confidence: 54%

Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease

D'avila

Guedes

Castro

et al. 2009

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 54%

Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease

D'avila

Guedes

Castro

et al. 2009

Mem. Inst. Oswaldo Cruz

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“…Bahia-Oliveira et al [38] , taking into account only the inflammatory actions of the cytokine, also described the dual role of IFN-γ during chronic Chagas disease. Our observations from the standpoint of the pleiotropic biological effects, both inflammatory and non-inflammatory, in Chagas disease made us remodel the concept as will follow in these review.…”

Section: Ifn-γ a Dual Role In Chagas Diseasementioning

confidence: 99%

Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy

Ferreira¹,

Frade²,

Baron³

et al. 2014

WJC

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Chagas disease cardiomyopathy (CCC), the main consequence of Trypanosoma cruzi (T.cruzi ) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon (IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of T.cruzi infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.

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“…In human patients' cardiac biopsies, among the mononuclear cells, macrophages and CD8 + T cells represent the majority of the infi ltrate (Higuchi et al 1997). IFN-γ can be detected in tissues via in situ immunohistochemistry (Bahia-Oliveira et al 1998, Correa-Oliveira et al 1999) and appears to be correlated with the presence of CD8 + T cells (Higuchi et al 1997, Reis et al 1997). In addition, T. cruzispecifi c human CTL have been identifi ed (Thomson et al 1998, Wizel et al 1998.…”

Section: Human Studiesmentioning

confidence: 99%

An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress

Zacks

Wen

Vyatkina

et al. 2005

An. Acad. Bras. Ciênc.

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There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stressinduced injuries that may contribute to disease progression. Pathogen invasion-and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role of oxidative stress in chagasic cardiomyopathy (CCM) remains incomplete. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, electron transport chain dysfunction and its role in sustaining oxidative stress in myocardium. We discuss the literature reporting the consequences of sustained oxidative stress in CCM pathogenesis.Key words: chagasic cardiomyopathy, reactive oxygen species, inflammation, mitochondria, oxidant/antioxidant status, oxidative damage. PARASITE, VECTOR AND TRANSMISSIONTrypanosoma cruzi, a parasitic protozoan of the ancient branch of eukaryotes (Kingdom Eukaryota, Order Kinetoplastida), is the etiological agent of Chagas disease in humans (Miles 2003). Currently, the World Health Organization estimates that 11-18 million individuals are infected worldwide (WHO 2002). Transmission of T. cruzi occurs predominantly via insect vectors of the subfamily Triatoma, family Reduviidae, referred to as " kissing bugs". Residing in the peridomestic habitat of mud-thatch Correspondence to: Nisha Garg Ph.D. E-mail: nigarg@utmb.edu houses in rural areas (Mott et al. 1978), Triatoma infestans in South America, Rhodnius prolixus in Venezuela, Colombia and Central America (Schofi eld and Dias 1999), and Triatoma barberi in Mexico (Guzman 2001), are the most common species responsible for transmission. Improvements in housing conditions and vector control measures instituted by the Southern Cone Initiative in 1991 have contributed to a decline in transmission in endemic countries (Schofi eld and Dias 1999). However, concern remains that reinfestation of homes by secondary sylvatic vectors, e.g. Triatoma sordida, will compromise the long-term effi cacy of vector control measures in Brazil and other Southern American countries (Monteiro et al. 2001, WHO 2002. Blood transfusion and organ transplantation represent further routes of T. cruzi transmission. Although many countries in Latin America screen blood donations for T. cruzi, infection rates ranging from 0.1% to 24.4% are estimated to occur through transfusion (WHO 2002).In the U.S., vector-transmitted human infections have been reported in the southern States (Ochs et al. 1996, Herwaldt et al. 2000. Several studies have shown the presence of the insect vector as well as infection of domestic dogs and wild animals in the US (Meurs et al. 1998, Bradley et al. 2000, Beard et al. 2003, Yabsley and Noblet 2002. Further, due to signifi cant increases in immigration to the USA and Canada from endemic countries and perinatal transmission, it is estimated that ∼ 100, 000 people residing...

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IFN-<FONT FACE=Symbol>g</font> in human Chagas' disease: protection or pathology?

Cited by 69 publications

References 16 publications

Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease

Immunological imbalance between IFN-³ and IL-10 levels in the sera of patients with the cardiac form of Chagas disease

Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy

An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress

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