Expression and cytokine secretion in the states of immune reactivation in leprosy

Sampaio, Elizabeth P.; Sarno, Euzenir Nunes

doi:10.1590/s0100-879x1998000100009

Cited by 17 publications

(15 citation statements)

References 14 publications

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“…This finding is similar to those observed by Nadkarni and Rege [11]. a Type 1 reaction that can occur once treatment is initiated in the latter category of patients [18,19].…”

Section: Discussionsupporting

confidence: 91%

Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

Kini¹,

Choudhury²

2017

J Interdiscipl Histopathol

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This study is a descriptive, hospital-based retrospective study. Skin biopsies obtained from patients clinically diagnosed as leprosy in the OPD and leprosy clinic of our institute between January 2012 and November 2015 were included in the study. The study was initiated after obtaining ethical clearance from the Ethics Committee of our institution. Slides stained with hematoxylin and eosin and Fite-Faraco were evaluated for features representing/indicative of leprosy. Cases positive for Hansen's disease were evaluated for the presence or absence of granulomas, type of cells comprising the granulomas, nature of the histiocytes-whether foamy/epithelioid, presence of epidermal involvement, evidence of neural involvement/ destruction, presence location and density of lymphocytes, type Clinicopathological correlation in diagnosis of Hansen's disease: A histopathologist's perspective

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“…This finding is similar to those observed by Nadkarni and Rege [11]. a Type 1 reaction that can occur once treatment is initiated in the latter category of patients [18,19].…”

Section: Discussionsupporting

confidence: 91%

Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

Kini¹,

Choudhury²

2017

J Interdiscipl Histopathol

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“…Incubation of sera with antihuman immunoglobulins and anticomplement fractions showed no immune complex deposition. Similar findings have been seen with ENL lesions 4,5 . However, in contrast to classic ENL, there was an increased number of γδ+ T cells in the dermis of these patients (Fig.…”

Section: Reportsupporting

confidence: 85%

Clinical, immunological and histological aspects of an uncommon type II reaction in patients with lepromatous leprosy

et al. 2008

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This study reports three cases of an unusual leprotic reaction characterized by superficial bullous ulcerative cutaneous lesions associated with high fever, malaise and oedema in patients with leprosy. Two patients responded to thalidomide treatment, with regression of the symptoms and skin ulcers. The third patient responded to thalidomide plus prednisone. Analysis of the ulcerated skin lesions showed dermal oedema with mononuclear cell infiltrate enriched for gammadelta-positive T lymphocytes and an increased number of Mycobaterium leprae bacilli within capillary endothelium. In contrast, gammadelta+ cells were decreased in or absent from the blood. Tumour necrosis factor-alpha and interleukin-6 were raised in the serum of the patients at the onset of the reaction. After the episode, cytokine levels and the percentage of gammadelta+ cells in the blood returned to normal. These cases characterize an uncommon leprotic reaction with clinical similarities to type II reaction and may indicate a significant role for gammadelta+ T cells in its pathogenesis.

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“…In the lepromatous forms, however, the reactional state, referred to as erythema nodosum leprosum (ENL), has an abundance of neutrophils and is associated with acute systemic symptoms. The reactivation of the immune response and the upregulation of proinflammatory cytokines have been broadly documented for both forms of reaction (19)(20)(21)34), and both are implicated in leprosy morbidity. Immunosuppressors such as corticosteroids and thalidomide have been the only treatment options available.…”

mentioning

confidence: 99%

High Matrix Metalloproteinase Production Correlates with Immune Activation and Leukocyte Migration in Leprosy Reactional Lesions

Teles

Amadeu

et al. 2010

Infect Immun

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Matrix metalloproteinases (MMPs) compose a family of zinc-and calcium-dependent proteolytic enzymes responsible for extracellular matrix (ECM) remodeling and the regulation of the trans-ECM migration of leukocytes, an important step in inflammatory processes as well as infectious diseases. MMPs are functionally classified according to their relative substrate specificities but have been shown to overlap. Collagenases (MMP-1, -8, and -13) degrade type I collagen, whereas gelatinases A and B (MMP-2 and -9, respectively) degrade denatured type I (gelatin) and type IV collagens, a major component of the basement membrane. Collagenases are produced by many cell types including lymphocytes, granulocytes, astrocytes, and activated macrophages (10, 18).MMP secretion takes place under tight regulatory mechanisms including transcriptional controls in addition to their release as proenzymes, requiring activation by specific proteases and cytokines present in the milieu (2,3,16). Also, the postactivation of MMPs is controlled by metalloproteinase tissue inhibitors (tissue inhibitor of MMP [TIMP]), a family of specific inhibitors, that bind to MMPs in a stoichiometric ratio.

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Expression and cytokine secretion in the states of immune reactivation in leprosy

Cited by 17 publications

References 14 publications

Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

Clinical, immunological and histological aspects of an uncommon type II reaction in patients with lepromatous leprosy

High Matrix Metalloproteinase Production Correlates with Immune Activation and Leukocyte Migration in Leprosy Reactional Lesions

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