Aging and immunoglobulin isotype patterns in oral tolerance

Faria, Ana Maria Caetano; Ficker, Sabine Madsen; Speziali, Elaine; Menezes, José Elmo de; Stransky, Beatriz; Verdolin, B. A.; Lahmann, W. M.; Rodrigues, Vanessa Gregório; Vaz, Nelson M.

doi:10.1590/s0100-879x1998000100005

Cited by 20 publications

(19 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In mice, some reports suggest that, with ageing, the levels of total and specific serum IgG and IgM increase (Koga et al, 2000), while other authors found a reduction in specific IgG and IgM in aged animals (Faria et al, 1998). Speziali et al (2009), have recently shown that basal levels of total serum immunoglobulins, IgG and IgA were increased while antigen-specific immunoglobulins, IgG and IgA were reduced in aged mice compared to young ones.…”

Section: B Lymphocytesmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

View full text Add to dashboard Cite

a b s t r a c tImmunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG + IgD − CD27 − ) that we have demonstrated is increased in healthy elderly.

show abstract

Section: B Lymphocytesmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

View full text Add to dashboard Cite

show abstract

“…Levels of parasitespecific immunoglobulin G1 (IgG1) and IgG2a were measured by ELISA as described elsewhere (8). A titration curve was plotted to determine the best protein concentration and antibody dilution.…”

mentioning

confidence: 99%

Immune Responses Induced by theLeishmania(Leishmania)donovaniA2 Antigen, but Not by the LACK Antigen, Are Protective against ExperimentalLeishmania(Leishmania)amazonensisInfection

Coelho¹,

Tavares²,

Carvalho³

et al. 2003

Infect Immun

210

199

View full text Add to dashboard Cite

Leishmania amazonensis is one of the major etiologic agents of a broad spectrum of clinical forms of leishmaniasis and has a wide geographical distribution in the Americas, which overlaps with the areas of transmission of many other Leishmania species. The LACK and A2 antigens are shared by various Leishmania species. A2 was previously shown to induce a potent Th1 immune response and protection against L. donovani infection in BALB/c mice. LACK is effective against L. major infection, but no significant protection against L. donovani infection was observed, in spite of the induction of a potent Th1 immune response. In an attempt to select candidate antigens for an American leishmaniasis vaccine, we investigated the protective effect of these recombinant antigens (rLACK and rA2) and recombinant interleukin-12 (rIL-12) against L. amazonensis infection in BALB/c mice. As expected, immunization with either rA2-rIL-12 or rLACK-rIL-12 induced a robust Th1 response prior to infection. However, only the BALB/c mice immunized with rA2-rIL-12 were protected against infection. Sustained gamma interferon (IFN-γ) production, high levels of anti-A2 antibodies, and low levels of parasite-specific antibodies were detected in these mice after infection. In contrast, mice immunized with rLACK-rIL-12 displayed decreased levels of IFN-γ and high levels of both anti-LACK and parasite-specific antibodies. Curiously, the association between rA2 and rLACK antigens in the same vaccine completely inhibited the rA2-specific IFN-γ and humoral responses and, consequently, the protective effect of the rA2 antigen against L. amazonensis infection. We concluded that A2, but not LACK, fits the requirements for a safe vaccine against American leishmaniasis

show abstract

“…circulating antibody formation [37][38][39][40][41][42][43]. Natural feeding of mice has been shown to result preferentially in oral tolerance to dietary components, specially with proteins repeatedly ingested on several consecutive occasions [38,41,44].…”

Section: Different Outcomes Of Mucosal Antigenic Exposuresmentioning

confidence: 99%

Immaturity, Ageing and Oral Tolerance

et al. 1997

View full text Add to dashboard Cite

Vaz NM, Faria AMC, Verdolin BA, Carvalho CR. Immaturity, Ageing and Oral Tolerance. Scand J Immunol 1997;46:225-229 Founding studies of cellular immunology emphasized that tolerance to allografts could only be achieved early in the embryonic or neonatal period, suggesting that the establishment of self-tolerance, a main event in the organization of the immune system, would necessarily take place in immature hosts. Contradicting these ideas, oral tolerance is a common, daily phenomenon, easily achieved by a physiological route in adult immunocompetent animals. Furthermore, there is solid evidence that, after the neonatal period, the susceptibility to oral tolerance induction also wanes and that it may be restored by adoptive transfer of cells from young hosts. These findings are briefly reviewed here to emphasize that immunological activity is a continuous and ongoing epigenesis extending throughout the entire life of the organism, far beyond the early phases of ontogenesis. Nelson M. Vaz, Department of Biochemistry and Immunology, CP 486, Instituto de Ciências Biológicas, Universidade Federal de Minas Gevais 30161-970, Belo Horizonte, MG, Brazil THE DOMINANT IMMUNOLOGICAL PARADIGMWe refer to the 'dominant immunological paradigm' [1] as a large interlaced set of terms and notions based on the concept of specific immunological recognition of foreign epitopes (immunity) and its complement, the notion of self-tolerance (self/nonself discrimination). The current version of the paradigm is based in different versions of the Clonal Selection Theory of Antibody Formation [2]. An alternative paradigm should be able to define, discuss and explain immunological activities and immunological phenomena without relying on the distinction between foreign and familiar materials (self/non-self discrimination) or on the notion of self-tolerance (self-ignorance). Up to this moment, we are not aware of such an alternative being fully formulated.In a previous essay [3], we pointed to a confusion of domains of description inherent to the current paradigm, which confounds the structural dynamics of the immune system (its physiology) with immunological phenomena (such as specific immune responses) which take place in the domain of interactions of the organism acting as a whole 1 . In the present essay, we use the same way of seeing to describe the set of phenomena currently described as 'oral tolerance'. We will show that these phenomena are not explained by the current paradigm and require alternative systemic notions to explain them. SELF-TOLERANCE AND IMMATURITYCreated in the early 1960s, the current immunological paradigm was heavily influenced by experimental findings on bovine twins' natural allogeneic chimeras [4], the rejection of allografts in mice [5,6] and chickens [7,8] and the adoptive transfer of immunological competence by lymphocytes [9][10][11][12]. The Clonal Selection Theory hinged around the notions of self/non-self discrimination (self-tolerance) already emphasized in a previous book by Burnet & Fenner [13], exp...

show abstract

Aging and immunoglobulin isotype patterns in oral tolerance

Cited by 20 publications

References 69 publications

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Immune Responses Induced by theLeishmania(Leishmania)donovaniA2 Antigen, but Not by the LACK Antigen, Are Protective against ExperimentalLeishmania(Leishmania)amazonensisInfection

Immaturity, Ageing and Oral Tolerance

Contact Info

Product

Resources

About