Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice

Umekita, Lilia F.; Ramos, Diana; Mota, I.

doi:10.1590/s0100-879x1997001000009

Cited by 7 publications

(4 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that good BCS of the animal result in development of immune elements present of serum controlling the overloading of parasites in animal. Umekita, et al [19] had long cited the importance of antibodies in resistance against the acute phase of T. cruzi infection. Previously, it was demonstrated that antibodies with lytic ability are only efficiently induced after immunization with living parasites and react with living but not with dead parasites [20].…”

Section: Discussionmentioning

confidence: 99%

Animal Trypanosomiasis in Cattle of Good Body Condition Score in the Adamawa Region of Cameroon: Hematological and Immunological Implications

Echi¹,

Jude²,

Farikou³

et al. 2020

Int J Trop Dis

View full text Add to dashboard Cite

The control of animal trypanosomiasis consists, amongst other things, the punctual treatment of new cases, primarily diagnosed by pastoralists on the basis of clinical signs. This practice suggests that many healthy infected animals are left untreated. In this study, animal trypanosomiasis in cattle of good body condition score was evaluated, the existence of polyclonal anti-trypanosome (Anti-tryps) and its serotherapy implications were discussed. From January to March 2020, the study was carried out in the Mission Special d'Eradication des Glossines in Ngaoundere. A total of 298 blood samples were collected from cattle in randomly selected ranches in Ngaoundere. The blood samples were subjected to parasitological examination using the buffy coat method and the packed cell volume determined. A serum sample of cattle with trypanosome was subjected to serotherapeutical study against Trypanosoma congolense in mice and the parasitemia and mortality were analyzed. An overall trypanosomiasis prevalence of 4.02% was found in the cattle examined. Trypanosome-infected cattle had significantly (P = 0.0001) lower Packed Cell Volumes (PCV). Anemia was highly associated with trypanosome infection (OR = 10.54; p = 0.0005). Species of trypanosomes identified were Trypanosoma congolense and Trypanosoma vivax. Concentration of 5 µl/g body weight of antiserum showed significantly (P = 0.02) protective effect in cure and passive immunization of mice. In conclusion, carriers of trypanosomes are present amongst cattle of good body condition score. Attempts to successfully reduce the population of reservoir of trypanosomes within herds and control the disease will need to consider mass screening including both animals of good and poor body conditions and anti-sera of trypanosomes will be a good candidate for therapeutical and preventive control.

show abstract

Section: Discussionmentioning

confidence: 99%

Animal Trypanosomiasis in Cattle of Good Body Condition Score in the Adamawa Region of Cameroon: Hematological and Immunological Implications

Echi¹,

Jude²,

Farikou³

et al. 2020

Int J Trop Dis

View full text Add to dashboard Cite

show abstract

“…Trypomastigotes obtained from successive peaks of parasitemia express antigenically distinct VSGs. The robust antibodies produced in response to the highly immunogenic VSG on the surface of one trypomastigote variant can eliminate most of the homologous parasitic variants by either complement-mediated lysis or phagocytosis, in which the antibodies function as opsonin ( Cross, 1975 ; Umekita et al., 1988 ; Umekita et al., 1997 ; Pays, 2006 ). At the same time, however, there is a selection of some trypomastigotes that express another set of VSGs to which the antibodies to the former variant are non-cross reactive, and thus are ineffective against the newly emerged heterologous variant ( Pays, 2006 ).…”

Section: Antigenic Variationmentioning

confidence: 99%

“…Trypanosomatids Variant-specific glycoproteins (Cross, 1975;Umekita et al, 1988;Umekita et al, 1997;Pays, 2006) Plasmodium spp.Babesia spp. Antigenic variation of the relapse variants (Cox, 1962;Brown and Brown, 1965;Hommel et al, 1983;al-Khedery et al, 1999;Winter et al, 2005;Recker et al, 2011;Reńia and Goh, 2016;Bloch et al, 2019) (Continued)…”

Section: Surface Antigen Variationmentioning

confidence: 99%

Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites

Chulanetra

Chaicumpa

2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

For the establishment of a successful infection, i.e., long-term parasitism and a complete life cycle, parasites use various diverse mechanisms and factors, which they may be inherently bestowed with, or may acquire from the natural vector biting the host at the infection prelude, or may take over from the infecting host, to outmaneuver, evade, overcome, and/or suppress the host immunity, both innately and adaptively. This narrative review summarizes the up-to-date strategies exploited by a number of representative human parasites (protozoa and helminths) to counteract the target host immune defense. The revisited information should be useful for designing diagnostics and therapeutics as well as vaccines against the respective parasitic infections.

show abstract

“…However, it is difficult to answer since clearance antibodies usually also have lytic ability, although these two abilities could be distinguished by the use of heterologous antisera (43). In this regard, it should be pointed out that antisera from the acute phase, in spite of their high lytic ability (38,39), have no clearance effect (40,41).…”

mentioning

confidence: 99%

How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi?

Umekita

Mota

2000

Braz J Med Biol Res

Self Cite

View full text Add to dashboard Cite

Host resistance to Trypanosoma cruzi is dependent on both natural and acquired immune responses. During the acute phase of the infection the presence of IFN-g, TNF-a, IL-12 and GM-CSF has been closely associated with resistance, whereas TGF-ß and IL-10 have been associated with susceptibility. Several investigators have demonstrated that antibodies are responsible for the survival of susceptible animals in the initial phase of infection and for the maintenance of low levels of parasitemia in the chronic phase. However, how this occurs is not yet understood. Our results and other data in the literature support the hypothesis that the protective role of antibodies in the acute phase of infection is dependent mostly on their ability to induce removal of bloodstream trypomastigotes from the circulation in addition to other concomitant cell-mediated events.

show abstract

Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice

Cited by 7 publications

References 11 publications

Animal Trypanosomiasis in Cattle of Good Body Condition Score in the Adamawa Region of Cameroon: Hematological and Immunological Implications

Animal Trypanosomiasis in Cattle of Good Body Condition Score in the Adamawa Region of Cameroon: Hematological and Immunological Implications

Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites

How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi?

Contact Info

Product

Resources

About