Levels of C-reactive protein in serum samples from healthy children and adults in São Paulo, Brazil

Abstract

C-reactive protein (CRP) was measured by ELISA in the sera of 165 healthy blood donors and 125 normal children 1 to 14 years old. The serum levels of blood donors ranged from 0.05 to 57.6 mg/l with median and mean values of 1.8 mg/l and 4.86 mg/l, respectively. CRP levels ranged from 0.02 to 14.4 mg/l in the children's sera, the median being 0.45 mg/l and the mean 1.65 mg/l. No individual lacking CRP was detected. The high CRP levels observed in the present study suggest that the population of the State of São Paulo may usually be exposed to subacute infections and/or inflammation without presenting clinical symptoms.

Serum Levels of High Sensitive C Reactive Protein in Healthy Adults From Southern Brazil

“…The wide range in the serum hs‐CRP levels obtained in the present study is consistent with previous studies , and may be resulted from the different undetectable stimulus and the genetic heterogeneity of the inflammatory response among the individuals . In the present study, middle age, female gender, and high BMI were associated with high serum hs‐CRP levels.…”

“…With the emergence of more sensitive and reliable immunoassays, it has been shown that CRP is present at low levels in the serum of all the clinically healthy individuals . When CRP concentration was measured using an enzyme‐linked immunosorbent assay (ELISA) in sera from healthy blood donors, the values ranged from 0.05 to 57.6 mg/l (median 1.8 mg/l) , and a non‐Gaussian distribution of CRP was demonstrated, with the 2.5th, 50.0th, and 97.5th percentile values of 0.08, 0.64, and 3.11 mg/l, respectively .…”

Neighborhoods and systemic inflammation: High CRP among legal and unauthorized Brazilian migrants

“…The 2005 2008 NHANES data indicate that women aged 18 64 in the United States are approximately 1.5 times as likely as men to have high CRP, and among foreign born Mexicans – the only foreign born group that may be identified – this gap is greater (Centers for Disease Control and Prevention, 2010). We also found that Brazilian men are 31 percent less likely to exhibit high CRP than women, and at least two studies conducted among Brazilians in Brazil similarly identified this gender gap in young and otherwise healthy populations (Araújo et al, 2004; Ribeiro, 1997). It will be worthwhile in future studies to clearly articulate hypotheses regarding the environmental and psychosocial factors that may help explain this disparity, in addition to potential hormonal differences that may influence CRP levels.…”

The efficacy of negative pressure wound therapy in treating sacroiliac joint tuberculosis with a chronic sinus tract: a case series

“…CRP, an acute phase protein, is synthesized by hepatocytes in response to pro-inflammatory cytokines, in particular interleukin (IL)-6 [29]. ESR and CRP, which will initially be elevated significantly, and normalize over time on therapy, in patients with active tuberculosis have been used to predict disease severity and curative effects for several decades.…”