Ouratea lancifolia R. G. Chacon &amp; K. Yamam. (Ochnaceae), uma nova espécie do Cerrado, Brasil

Phytochemical studies of Cespedesia spathulata (Ochnaceae) leaves using 1 H, 13 C NMR, and GC-MS have led to the isolation of some metabolites identifi ed for the fi rst time in these species such as cathechin, epicatechin, vitexin, orientin, 6''-O-acetylvitexin, sitosterol, stigmasterol, phytol, 4,5-dihydrovomifoliol and a mixture of aliphatic methyl esters, together with ochnafl avone, which was previously isolated from this plant.The modulating activity of some fractions and compounds from Cespedesia spathulata towards tyrosinase enzyme was assayed by spectroscopic and theoretical means/ experiments. The dichloromethane fraction (133 μg mL -1 ) and ochnafl avone (333 μM) inhibited tyrosinase activity by 20 % and 2.0 %, respectively, whereas the ethyl acetate fraction (666 μg mL -1 ) and ±catechins (catechin and epicatechin -800 μM) activated it by 104 % and 384 %, respectively. Quantum chemical calculations suggested that catechin and epicatechin are better activators than L-DOPA by interacting with Cu (II) ions. Molecular docking results suggested that hydrogen bonding and hydrophobic interactions are the main binding forces between each tyrosinase activator and the amino acid residues inside the active protein binding pocket.

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Phytochemical profile of Cespedesia spathulata leaves (Ochnaceae) and its effect on tyrosinase enzyme

Oliveira

Silva

Chaves

et al. 2021

An. Acad. Bras. Ciênc.

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Ouratea cataniapoensis, a New Name for O. megaphylla (Ochnaceae)

Aymard

2018

Harvard Papers in Botany

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Ouratea lancifolia R. G. Chacon & K. Yamam. (Ochnaceae), uma nova espécie do Cerrado, Brasil

Cited by 2 publications

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Phytochemical profile of Cespedesia spathulata leaves (Ochnaceae) and its effect on tyrosinase enzyme

Phytochemical profile of Cespedesia spathulata leaves (Ochnaceae) and its effect on tyrosinase enzyme

Ouratea cataniapoensis, a New Name for O. megaphylla (Ochnaceae)

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