Indicadores bioquímico e hormonal de vacas leiteiras mestiças sadias e doentes durante o final da gestação e o início da lactação

Filho, Alonso Pereira Silva; Mendonça, Carla Lopes de; Souto, Rodolfo José Cavalcanti; Silva, Rafael J.; Soares, Pierre Castro; Afonso, José Augusto Bastos

doi:10.1590/s0100-736x2017001100007

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…βHB concentrations were stable between groups and moments, demonstrating only slightly higher values than those reported by Silva Filho et al [28] in healthy dairy cattle at 60 days postpartum. Despite the slight elevation, these values remained within normal limits, thus excluding the possibility of concomitant diagnosis of clinical ketosis in the animals in this study.…”

Section: Discussioncontrasting

confidence: 68%

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Ribeiro

Soares

Coutinho

et al. 2020

Acta Scientiae. Vet.

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Background: Displaced abomasum (DA) is a common and economically important disorder that affects dairy cattle. Nutritional factors and adaptive responses that occur in the peripartum play a central role in the pathogenesis. The measurement of blood metabolites represents a useful tool for monitoring and prognostic determination in affected animals. Therefore, the objective was to evaluate cardiac, energy and hormonal blood markers, lactatemia, and insulin sensitivity in cows diagnosed with right displaced abomasum (RDA) and left displaced abomasum (LDA), comparing them with each other.Materials, Methods & Results: Nineteen cases of abomasum displacement in cows were studied, including 9 cases of RDA and 10 cases of LDA. The diagnosis was established by means of physical examination and measurement of the concentration of chlorides in the ruminal fluid (> 30mEq/L). After diagnosis, clinical-surgical therapeutic management was instituted. At the time of diagnosis (M1) and at the resolution of the case (M2), blood samples were collected to assess the variables: non-esterified fatty acids (NEFA), beta hydroxybutyrate (βHB), L-lactate, creatine kinase (CK), creatine kinase MB (CK-MB), cardiac troponin I (cTnI), lactate dehydrogenase (LDH), glucose, insulin, and cortisol. In addition, insulin sensitivity was estimated using the Revised Quantitative Insulin Sensitivity Check Index (RQUICKI) and RQUICKI-βHB. The means of the variables were compared, separating the effects of groups (RDA and LDA) and moments (M1 and M2), at the level of 5% probability. The concentrations of NEFA, CK-MB, L-lactate, glucose, insulin, and cortisol were higher at M1 and the RQUICKI and RQUICKI-βHB indices were lower at this moment. L-lactate, CK, and CK-MB were higher in the RDA group, while cTnI, βHB, and LDH did not present a group or moment effect. Cardiac markers correlated with the energy profile metabolites, L-lactate, and cortisol.Discussion: The high concentrations of NEFA at M1 reflected the condition of negative energy balance. βHB concentrations were stable, that may be related to the number of days postpartum in which the animals were diagnosed. The hyperglycemic condition and the increase in serum cortisol concentrations found at M1 can be induced by the condition of metabolic stress resulting from the disease. Hyperinsulinemia were recorded in the present study could be an important factor related to the pathogenesis of DA, since there seems to be a correlation between hyperinsulinemia and decreased abomasal emptying rate. The RQUICKI and RQUICKI-βHB indices was significantly lower at M1, which may indicate lower sensitivity of peripheral tissues to insulin at this time. Changes in serum activity of LDH and CK may result from tissue damage due to organ displacement, in addition to damage associated with surgery and the administration of injectable drugs, mainly intramuscularly. The elevation in plasma L-lactate at M1 and in the RDA group may be associated with abomasal hypoperfusion. The high positive correlations found between L-lactate and the variables glucose, insulin, and cortisol reinforcing the association between the concentration of L-lactate and the moment of greatest stress. The increase in cardiac biomarkers may be related to the occurrence of ischemia/reperfusion injury in the abomasum, which involves oxidative stress and the production of inflammatory mediators. The hyperglycemic condition and the higher concentrations of NEFA can also contribute to the occurrence of myocardial injury. The correlations found between cardiac biomarkers and plasma L-lactate, strengthen the idea that there is a relationship between L-lactate and myocardial injury. In this sense, the measurement of blood concentrations of cTnI, CK-MB, and L-lactate could contribute as severity markers and prognosis indicators in cattle with DA.

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Section: Discussioncontrasting

confidence: 68%

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Ribeiro

Soares

Coutinho

et al. 2020

Acta Scientiae. Vet.

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Effect of changes in body condition during the dry period, milk yield and genetic groups on the metabolic profiles of high-producing Holstein × Gir cows

et al. 2022

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Protein, enzymatic and mineral indicators of clinical and subclinical pregnancy toxemia during the transitional period in dairy goats

Souto,

Soares,

Macedo

et al. 2023

Ciênc. anim. bras.

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The purpose of this study was to evaluate the influence of clinical and subclinical pregnancy toxemia (PT) forms on the dynamics of blood metabolites, composing the protein, enzymatic and mineral profiles of dairy goats during the transitional period. 111 multiparous dairy goats were used in this research. The animals were raised under an intensive system. Experimental groups (n=3) were created using the βHB blood concentrations as a cut-off point. The G1 or control group (n = 40), G2 or subclinical PT group (n = 39) were established when least one of the experimental assessment times presented βHB values between 0.8 mmol/L and 1.6 mmol/L; whereas G3 or clinical PT group (n = 32), which at any of the experimental assessment times of βHB values were higher than 1.6 mmol / L when verified and also presented clinical signs of PT. The animals were evaluated on the 30th , 20th and 10th day ante-partum (dap), at parturition and on the 10th, 20th and 30th day postpartum (dpp). Total proteins (TP), albumin, globulin, urea, creatinine, aspartate aminotransferase (AST), Gamma glutamiltransferase (GGT), creatine kinase (CK), amylase, phosphorus, chloride and calcium, sodium and potassium ions were measured. The analysis of variance (F Test) was performed in order to investigate the effects and interactions between group and assessment times. Clinical and/or subclinical disease during the transitional period resulted in an increase of phosphorus and potassium concentrations (P<0.05), while a decrease in total protein, albumin, globulin, and ionized calcium values was observed (P<0.05). No statistical effect of PT on urea, creatinine, AST, GGT, CK, amylase and sodium was observed (P>0.05). Except the ionized calcium and phosphorus, the levels of all the metabolites were influenced (P<0.05) by late pregnancy, parturition and lactation. The occurrence of the subclinical form was higher than the clinical form during the transitional period. Among the all variables studied, mineral profile were those that suffered alteration resulting from PT, highlighting the ionized calcium. Attention is drawn to the magnitude of the impact of disease on these components interfering in animal health.

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Indicadores bioquímico e hormonal de vacas leiteiras mestiças sadias e doentes durante o final da gestação e o início da lactação

Cited by 5 publications

References 38 publications

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Cardiac, Energy and Hormonal Blood Markers, and Lactatemia in Cows with Displaced Abomasum

Effect of changes in body condition during the dry period, milk yield and genetic groups on the metabolic profiles of high-producing Holstein × Gir cows

Protein, enzymatic and mineral indicators of clinical and subclinical pregnancy toxemia during the transitional period in dairy goats

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