Fipronil/(S)-methoprene spot-on to control fleas on cats in a field trial in Spain

Lamelas, María Teresa; Calvete, C.; Estrada, Rolando; Marcén, J. M.; Pinal, R.; Peribáñez, Miguel A.

doi:10.1590/s0100-736x2017000600012

Cited by 4 publications

(2 citation statements)

References 18 publications

(23 reference statements)

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“…It prevented infestation for about four weeks, followed by fipronil alone and, lastly, the combination of imidacloprid / permethrin. A monthly dosing interval (28) is necessary to reduce the reappearance and massive infestation of dogs with fleas and ticks and decrease the environmental reservoir, so remission of clinical signs was achieved (47,48).…”

Section: Discussionmentioning

confidence: 99%

The Anti-Ectoparasite Effects of Different Topical Spots-on Formulation Against Ticks and Fleas in Naturally Infested Stray and Owned Dogs

Fawzi,

Youssef,

Ras

et al. 2021

SVR

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Ectoparasites poses potential hazards and are a constant challenge for veterinarians and pet owners worldwide. This clinical field study was conducted to assess the efficacy of different topical spot-on formulations against ticks and fleas in naturally infected dogs admitted for clinical examination at the Veterinary Hospital, Faculty of Veterinary Medicine, Sharkia Governorate, Egypt. Herein, forty dogs showed ectoparasites infestation were enrolled. These dogs were divided into four groups (ten each). Group1 (G1) considered as untreated control. The other three groups (G2, G3, and G4) were treated with fipronil 9.8% (Fipron spot-on solution), a combination of 9.8% fipronil/(S)-9.8% methoprene (Frontline Plus®), and imidacloprid/permethrin (K9-Advantix®), respectively. Clinical (all the dogs were clinically monitored throughout the experiment), parasitological (ticks and fleas (adult and eggs) were counted and identified on days 0, 1, 2, 7, 15, 21, 30, and 45 after treatment, and zootechnical (live-weight gain) analyses were conducted. Throughout the experiment, no adverse symptoms were observed in any of the treated animals. The synergistic effect of each topical spot-on was compared for eliminating ticks and fleas, aiming to obtain the ideal treatment model. Our results suggest that fipronil/(S)-methoprene outperformed fipronil alone in controlling ticks and fleas in naturally infested dogs. Also, it may be productive in the struggle against different tick and flea species infesting dogs as it gives protection for at least four weeks. In comparison to the other two topical spot-on formulations used in this study, imidacloprid/permethrin was the least effective, particularly against fleas. Overall, because these ectoparasites concern animal welfare and human health, this study underlines the importance of continued ectoparasites monitoring and educating pet owners about the impacts of flea and tick infestations as well as pathogenic hazards.

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Section: Discussionmentioning

confidence: 99%

The Anti-Ectoparasite Effects of Different Topical Spots-on Formulation Against Ticks and Fleas in Naturally Infested Stray and Owned Dogs

Fawzi,

Youssef,

Ras

et al. 2021

SVR

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“…Dryden et al [9] reported an effective eradication of fleas using topical SE and FL in cats. Gracia et al [10], reported the efficacy of topical FM to control fleas on cats. Tielemans et al [11], indicated the efficacy of topical FMEP against ticks on cats.…”

Section: Discussionmentioning

confidence: 99%

Usability Comparison Study of Spot-on Formulations of Parasiticides in Cats

Chansiripornchai¹

2020

CTCMS

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The aim of this study was to evaluate the usability of spot-on parasiticides for cats from the aspects of their stickiness and drying time after application. Eighteen client-owned healthy, munchkin cats (3 males, 15 females), between 9-month-old and 6-year-old, weighing from 1.5-2.9 kg were used in the study. Six spot-on parasiticides which are commercially available in Thailand including selamectin (SE), moxidectin + imidacloprid (MI), praziquantel + emodepside(PE), fipronil + (S)-methoprene + eprinomectin + praziquantel (FMEP), fluralaner (FL) and fipronil + (S)-methoprene (FM) were assessed after their respective application to the skin between shoulder blades of the 18 cats. Stickiness scores (STS) and drying time scores (DTS) were evaluated and recorded at 0.5, 1, 3, 6, 9, 12, 24 and 48 h after drug administration (DA). SE and MI groups showed the most satisfying scores of STS at 3 h after DA, STS in all groups was zero (not sticky) at 48 h after DA. For DTS, the SE and FL groups had the most satisfying score at 0.5 and 1 h after DA, DTS in all groups were zero (dry) at 24 h after DA. Some skin lesions such as erythema and alopecia were found in the MI and FMEP groups but the lesions completely recovered and all cats had normal general health throughout the study. From the study results, all of the 6 spot-on parasiticides are safe for cats and are acceptable for cat owners.

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Methoprene

Monteiro

2024

Encyclopedia of Toxicology

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Fipronil/(S)-methoprene spot-on to control fleas on cats in a field trial in Spain

Cited by 4 publications

References 18 publications

The Anti-Ectoparasite Effects of Different Topical Spots-on Formulation Against Ticks and Fleas in Naturally Infested Stray and Owned Dogs

The Anti-Ectoparasite Effects of Different Topical Spots-on Formulation Against Ticks and Fleas in Naturally Infested Stray and Owned Dogs

Usability Comparison Study of Spot-on Formulations of Parasiticides in Cats

Methoprene

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