Mecanismos da intoxicação do fígado de rato causada pelo gossipol

Carvalho, Wanderson Luís de; Maioli, Marcos A.; Mendes, Luiz Cláudio Nogueira; Rozza, Daniela Bernadete; Mingatto, Fábio Ermínio

doi:10.1590/s0100-736x2013000300011

Cited by 4 publications

(3 citation statements)

References 23 publications

(17 reference statements)

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“…and observed increases in GSH and reductions in GSSG concentration. However, the results obtained in the present study are consistent with those found by Carvalho et al [ 30 ] who observed a significant decrease in the level of GSH in liver homogenate of rats treated with 5 mg/kg BW gossypol compared to control animals, with a consequent increase in the concentration of GSSG. In addition, according to the results of the present study, vitamin E was able to protect against the oxidative effect of gossypol on glutathione.…”

Section: Discussionsupporting

confidence: 93%

“…These effects are consistently illustrated in this study, since there was an increase in the formation of MDA in the testis homogenate of animals treated with gossypol, indicating the occurrence of lipid peroxidation. A similar result was reported by Carvalho et al [ 30 ] when evaluating the effects of gossypol on rat livers. Treatment with vitamin E protected against this effect in the testes, which can be attributed to the fact that vitamin E is the major antioxidant in cell membranes, acting on polyunsaturated fatty acids and preventing their oxidation [ 34 ].…”

Section: Discussionsupporting

confidence: 89%

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Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

et al. 2015

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BackgroundGossypol is a chemical present in the seeds of cotton plants (Gossypium sp.) that reduces fertility in farm animals. Vitamin E is an antioxidant and may help to protect cells and tissues against the deleterious effects of free radicals. The aim of this study was to evaluate the mechanisms of reproductive toxicity of gossypol in rats and the protective effects of vitamin E. Forty Wistar rats were used, divided into four experimental groups (n = 10): DMSO/saline + corn oil; DMSO/saline + vitamin E; gossypol + corn oil; and gossypol + vitamin E.ResultsFertility was significantly reduced in male rats treated with gossypol in that a significant decrease in epididymal sperm count was observed (P < 0.05) and the number of offspring was significantly reduced in females mated with them (P < 0.05). This dysfunction was prevented by vitamin E. Gossypol caused a significant increase in the activity of the enzymes glutathione peroxidase (P < 0.01) and glutathione reductase (P < 0.01), but vitamin E did not reduce the enzyme activities (P > 0.05). The levels of reduced glutathione and pyridine nucleotides in testis homogenate were significantly reduced by gossypol (P < 0.05 and P < 0.01, respectively) and this reduction was accompanied by increased levels of oxidized glutathione (P < 0.05). Vitamin E showed a preventive effect on the changes in the levels of these substances. Gossypol significantly increased the levels of malondialdehyde (P < 0.01), a lipid peroxidation indicator, whereas treatment with vitamin E inhibited the action of the gossypol. Vitamin E prevented a decrease in mitochondrial ATP induced by gossypol (P < 0.05).ConclusionsThis study suggests that the reproductive dysfunction caused by gossypol may be related to oxidative stress and mitochondrial bioenergetic damage and that treatment with vitamin E can prevent the infertility caused by the toxin.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

et al. 2015

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“…Even the liver being the main metabolizing organ of xenobiotics (De Carvalho et al, 2013), it was demonstrated that NDGA can cause cystic nephropathy in rats. Its occur due to the quinone resulting from the metabolism process of NDGA absorbed by the proximal tubular epithelium and accumulate in the lysosomes, thus leading to the destruction of tubular epithelial cells and tubule blockage (Goodman et al 1970;Evan, Gardner, 1979) (Figure 3).…”

Section: Toxicitymentioning

confidence: 99%

Chemical and biological properties of nordihydroguaiaretic acid

Macena

Renzi

Grigoletto

2022

Braz. J. Pharm. Sci.

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Nordihydroguaiaretic acid (NDGA) is a natural product obtained by the alkaline extraction of dried plants of Larrea tridentata species. Due to the biological properties presented, such as antioxidant, anti-inflammatory, antiviral and cytotoxic capacity, this compound is being increasingly studied. In this review, it was evaluated the benefits of NDGA against different animal models. Besides that, it was found that this compound has antitumor activity similar to its synthetic derivative terameprocol in prostate tumors. The hypoglycemic effect may be evidenced by the inhibition of sugar uptake by NDGA; in obesity, studies have observed that NDGA presented a positive regulatory effect for Peroxisome proliferator-activated receptors (PPAR-α) involved in the oxidation of hepatic fatty acids and reduced the expression of lipogenic genes. Regarding its antioxidant potential, its mechanism is related to the ability to in vitro scavenging reactive substances. Although there are several studies demonstrating the benefits of using NDGA, there are also reports of its toxicity, mainly of liver damage and nephrotoxicity.

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Health concerns of lambs fed cottonseed hulls combined with chitosan by examining the blood metabolic profile and histopathology of the kidney, liver, and rumen

Magalhães¹,

Carvalho²,

Santos³

et al. 2021

Vet. Med. - Czech

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This study analysed the effect of cottonseed hulls and chitosan in diets for lambs by determining the blood metabolite profile, and the histopathology of the kidney, liver, and rumen. Eighty non-castrated Santa Inês lambs, approximately 120 days of age and a mean initial body weight (b.w.) of 22.6 (standard deviation ± 2.2 kg) were assigned to a completely randomised design, with a 2 × 2 factorial arrangement. Two chitosan levels and two cottonseed forms were evaluated. The experimental diets were following: diet containing whole cottonseed hulls (WC) without the addition of chitosan; diet containing WC with 136 mg/kg b.w. chitosan added; diet containing ground cottonseed hulls (GC) without the addition of chitosan; diet containing GC with 136 mg/kg b.w. chitosan added. The blood metabolites and hepatic enzymes ALT, AST, GGT were not significantly influenced in the treatment groups, except for the serum cholesterol concentration which was lower (P < 0.05) when the chitosan was combined with the whole cottonseed hulls. There were histopathological alterations (P < 0.05) in the liver and kidney tissue and moderate changes in the rumen samples in the animals fed cottonseed without chitosan, however, when chitosan was added, the changes were less marked. The combination of chitosan with cottonseed hulls (ground or whole) can be supplied safely to feedlot finishing lambs without compromising their health.

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Mecanismos da intoxicação do fígado de rato causada pelo gossipol

Cited by 4 publications

References 23 publications

Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E

Chemical and biological properties of nordihydroguaiaretic acid

Health concerns of lambs fed cottonseed hulls combined with chitosan by examining the blood metabolic profile and histopathology of the kidney, liver, and rumen

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