The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon

Gonkowski, Sławomir; Calka, J.

doi:10.1590/s0100-736x2012001300014

Cited by 1 publication

(2 citation statements)

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“…However, observed changes are difficult to explain and may be the result of primary or secondary (pain reaction) actions of pathogenic factors and take place in the transcriptional, translational or metabolic level. Moreover, previous studies show different changes in SOM-LI enteroendocrine cells according to various pathological conditions (4,(18)(19)(20)(21) discrepancies probably result both from interspecies differences and characters of pathological factors studied.…”

Section: Discussionmentioning

confidence: 91%

“…It is well-known that the GI tract is the largest endocrine organ in the body, which contains various classes of enteroendocrine cells distributed in the glands and epithelial cells (3), containing several biological active factors (4-7) and playing multiple roles, such as the control of peristaltic movements, secretion of gastric and intestinal glands, blood flow, regulation of feeding behavior as well as adaptive and reparative processes within the GI tract (3,4,8,9). Somatostatin is one of the substances, which is widely distributed in the gastrointestinal tract, both in the enteric nervous system and in the enteroendocrine cells (7,10,11).…”

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confidence: 99%

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Somatostatin as an Active Substance of Enteroendocrine Cells in the Canine Digestive Tract in Physiological Conditions and during Inflammatory Bowel Disease

2013

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The aim of the present investigation is to examine the changes in the number of somatostatin-like immunoreactive (SOM-LI) enteroendocrine cells in various parts of the canine gastrointestinal (GI) tract during canine inflammatory bowel disease (IBD). The distribution of SOM-LI enteroendocrine cells was studied using the double-labeling immunofluorescence technique with antisera against chromogranin A (CgA; used here as a marker of enteroendocrine cells) and somatostatin (SOM). Evaluation of the number of CgA-positive cells, which also contained SOM in the mucosal layer of canine stomach, duodenum, jejunum and descending colon was based on the counting of such cells per unit area (0.1 mm2). In physiological conditions, the number of SOM-LI enteroendocrine cells has been shown to constitute 5.30±2.07 in the stomach, 2.23±0.56 in the duodenum, 1.86±0.48 in the jejunum and 1.19±0.36 in the descending colon. Canine IBD caused an increase in the number of cells studied in the stomach (to 9.55±1.46) and the jejunum (to 3.84±1.16), while the changes observed in the duodenum and the descending colon have not been statistically significant. The obtained results suggest that SOM-LI enteroendocrine cells, as well as somatostatin, may be involved in pathological processes during canine IBD. Moreover, this study can be treated as the first step of application of SOM and/or its analogues in the treatment of canine IBD in the future.

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