Abortos em equinos na região sul do Rio Grande do Sul: estudo de 72 casos

Marcolongo-Pereira, Clairton; Adrien, María de Lourdes; Ladeira, Sílvia Regina Leal; Soares, Mauro Pereira; Assis-Brasil, Nathalia Dode de; Schild, Ana Lúcia

doi:10.1590/s0100-736x2012000100005

Cited by 13 publications

(24 citation statements)

References 17 publications

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“…Of the 105 aborted fetuses, stillbirths and perinatal deaths submitted for differential diagnosis of causes of abortion or perinatal mortality, 53 were submitted to bacteriological analysis with 16 found positive for bacterial agents representing 30.0% of those tested. Other studies point to bacterial infections as the cause of 20-34% of equine infectious abortions, representing an important economic loss (MOREIRA et al, 1998;GENOVEZ et al, 1995;LAUGIER et al, 2011;MARCOLONGO-PEREIRA et al, 2012). In the present study, the predominant agents isolated were E. coli in 4 of the 16 positive samples, E. aerogenes (3/16); E. coli + Streptococcus spp.…”

Section: Discussionsupporting

confidence: 49%

“…Studies of causes of abortion, stillbirth and perinatal mortality can help to identify the primary pathogens or other factors involved and define appropriate measures to reduce its occurrence. The most recent report from Brazil was conducted from January 2000 to June 2011 and presented data from a single region of the country (MARCOLONGO-PEREIRA et al, 2012). Further research is needed to expand available information.…”

Section: Abstract: Equus Caballus; Infectious Diseases; Reproductionmentioning

confidence: 99%

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Causes of equine abortion, stillbirth, and perinatal mortality in Brazil

et al. 2020

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Abortion and complications in reproduction are important causes of economic loss in horse breeding. Studies of its causal agents can help to identify the primary pathogens or other factors involved and define appropriate measures to reduce its occurrence. This research aimed to investigate the primary causes of equine abortion, stillbirth, and perinatal mortality in regions of Brazil. Tissue from aborted fetuses, stillbirths, neonates and foals submitted to the Biological Institute of São Paulo, Brazil, from January 2010 to July 2013 were processed for viral and bacterial isolation, polymerase chain reaction (PCR), histology, and immunohistochemistry. Bacterial infection was the primary detected cause of abortion, found in 16 of the 53 animals submitted for bacterial analysis followed by viruses analysis in 2 of 105 animals, and noninfectious causes (neonatal isoerythrolysis) in 2 of 105 animals. Fungi were found in a single sample of 53 tested. The most frequent bacteria recovered were Escherichia coli, Enterobacter aerogenes, combined E. coli and Streptococcus spp., Staphylococcus spp., and Bacillus spp. The following agents were each observed in a single sample: Arcanobacterium pyogenes, Streptococcus spp., Corynebacterium spp., Actinobacillus spp., and Rhodococcus equi. The predominant identification of fecal and other opportunistic bacteria as opposed to pathogens commonly associated with equine abortion, such as Leptospira spp. and equine herpesvirus type 1 (EHV-1), suggests the need of improving hygiene management of breeding mares to prevent bacterial infection that may cause fetal loss, stillbirth, and perinatal mortality.

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Section: Discussionsupporting

confidence: 49%

Section: Abstract: Equus Caballus; Infectious Diseases; Reproductionmentioning

confidence: 99%

Causes of equine abortion, stillbirth, and perinatal mortality in Brazil

et al. 2020

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“…Since the etiology of approximately half of the cases of abortion in Brazil is unknown [21,22] and there is no previous information regarding the prevalence of the disease, it is possible that GBED has been silently contributing to abortion in horses throughout the years and resulting in large economic losses. This highlights the need to know the genotype of the animals to guide the mating selection, avoiding the production of affected foals.…”

Section: Discussionmentioning

confidence: 99%

“…However, studies conducted in the United Kingdom, France, and the United States determined that in 7.8%-25.1% of the abortion cases, the etiology was not identified [18][19][20]. In Brazil, this scenario is even worse, and it is estimated that the cause of abortion in horses is unknown in 47.2%-54% of the cases [21,22]. In the United States, 1.3%-3.8% of abortion cases in QHs are caused by GBED [13].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of the Glycogen Branching Enzyme Deficiency Mutation in Quarter Horses in Brazil

Araújo

Delfiol

Badial

et al. 2018

Journal of Equine Veterinary Science

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Glycogen branching enzyme deficiency (GBED) is a fatal autosomal inherited disease affecting horses and caused by a nonsense mutation (c.102C>A) in the GBE1 gene. This disease strongly impairs the glycogen metabolism of affected animals resulting in abortion or early death of foals. Although understanding the prevalence of heterozygous for GBED is imperative to estimate the impact of the disease, prevalence studies have yet to be performed in Brazil. The aim of this study was to determine the prevalence of heterozygous of the GBED mutation in a population of Quarter Horses in Brazil. Blood samples were obtained from 742 animals competing in distinct disciplines including cutting, halter, race, reining, and barrel racing. All samples were submitted to DNA purification, amplification, and sequencing of the target fragment. The overall GBED prevalence of carriers was 7.95% (59/742). The prevalence of heterozygotes by discipline was considered higher in cutting (19.75% [32/162]) and reining (10% [16/160]) subgroups followed by barrel racing (5% [8/160]) and halter (3% [3/100]) horses. There were none heterozygous in the racing subgroup. These results demonstrate the GBED causative mutation in the Brazilian Quarter Horse herd and suggest the occurrence of the disease. Therefore, GBED is a disease that should be considered in the differential diagnosis of abortion and stillbirths, especially if suspect foals are products of two heterozygous. Besides testing aborted foals for the GBED mutation, the molecular diagnosis should be recommended to owners and breeders, at least for those breeding the at-most-risk subgroups of horses, to guiding their mating selections and, therefore, prevent the transmission of the mutation.

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“…Num estudo realizado no Sul do Rio Grande do Sul entre 2000 e 2011 abortos devidos a causas bacterianas representaram 68,4% dos casos, sendo Klebisiella pneumoniae, Leptospira sp. e Streptococcus beta hemolítico as bactérias mais frequentes (Marcolongo-Pereira et al 2012a).…”

Section: Resultsunclassified

Doenças de equinos na região Sul do Rio Grande do Sul

et al. 2014

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A retrospective study of the diagnoses of injuries and deaths in equine in Southern Brazil was conducted between 1978 and 2012. All necropsy protocols and other materials of the Regional Diagnostic Laboratory of the Veterinary School of the Federal University of Pelotas were reviewed. The collected data consisted of 2,026 equine materials, including 514 necropsy protocols of and 1,512 other biologic materials, including the protocols of biopsies, organs, swabs, feces, blood, and skin scrapings. From the resulting 2,026 diagnoses, 467 (23.05%) corresponded to neoplasms and tumor like lesions; 168 (8.29%) to parasitic diseases; 135 (6.66%) to bacterial diseases; 31 (1.53%) to viral diseases; 86 (4.24%) to diseases caused by fungi and oomycetes; 50 (2.47%) to intoxication and poisoning by mycotoxins; 9 (0.44%) to metabolic diseases; 60 (2.96%) to other diseases; and 75 (3.70%) to non-transmittable diseases of the digestive tract. Three hundred twenty cases (15.79%) were classified as diseases of unknown etiology. Other diagnoses accounted for 489 of the total 2,026 cases (24.14%). In 44 (8.56%) of the 514 necropsies and 91 (9.47%) of the 961 biopsies of organs mailed into the laboratory, the diagnoses were inconclusive, totaling 135 (9.15%) of the 1,475 in the category. This study demonstrates the importance of skin lesions in horses, as 31.88% (642) of the biopsies received were lesions on the skin of the animals. The most significant tumors observed were equine sarcoid, at 33.18%, and squamous cell carcinoma, at 7.94%. The most common observed causes of death were leucoenceflomalacia (7.59%), rabies (3.70%) thromboembolism by Strongylus vulgaris (2.33%) and monocytic ehrlichiosis (1.75%). INDEX TERMS: Horses, disease of horses, retrospective study, pathology.

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Abortos em equinos na região sul do Rio Grande do Sul: estudo de 72 casos

Cited by 13 publications

References 17 publications

Causes of equine abortion, stillbirth, and perinatal mortality in Brazil

Causes of equine abortion, stillbirth, and perinatal mortality in Brazil

Prevalence of the Glycogen Branching Enzyme Deficiency Mutation in Quarter Horses in Brazil

Doenças de equinos na região Sul do Rio Grande do Sul

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