Morfometria das fibras colágeno cardíaco em ratos sadios e diabéticos suplementados com vitamina C

Diniz, Thiago Guerra; Benedicto, Hildebrando Gomes; Agreste, Fernanda Rodrigues; Clebis, Naianne Kelly; Hernandez‐Blazquez, Francisco Javier; Bombonato, Pedro Primo

doi:10.1590/s0100-736x2011001300001

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“…Generally, the cardiac remodeling arises in diabetic rats after 3 months of induction of the disease 8 . It is well known that Advanced Glycation End (AGE) products synthesized during obesity and IR cooperate with cardiac fibrosis by interaction with the receptor of AGE (RAGE), which stimulates the release of pro-fibrotic growth factors, as well as collagen deposition 50 . In addition, AGEs promote stiffening of cardiac collagen through crosslinks between type 1 collagen molecules 47 .…”

Section: Discussionmentioning

confidence: 99%

Supplementation with okra combined or not with exercise training is able to protect the heart of animals with metabolic syndrome

Gomes

Moura

Cardoso

et al. 2023

Sci Rep

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The metabolic syndrome (MetS) is a clinical manifestation strongly associated with cardiovascular disease, the main cause of death worldwide. In view of this scenario, many therapeutic proposals have appeared in order to optimize the treatment of individuals with MetS, including the practice of exercise training (ET) and the consumption of okra (O). The aim of the present study was to evaluate the effect of O consumption and/or ET in animals with MetS. In all, 32 male Zucker rats (fa/fa) at 10 weeks old were randomly distributed into four groups of 8 animals each: MetS, MetS+O, MetS+ET and MetS+ET+O, and 8 lean Zucker rats (fa/ +) comprised the control group. Okra was administered by orogastric gavage 2x/day (morning and night, 100 mg/kg), 5 days/week, for 6 weeks. The ET was performed on a treadmill 1x/day (afternoon), 5 days/week, 60 min/day, in an intensity of 70% of maximal capacity, for the same days of O treatment. It was found that, O consumption alone was able to promote improved insulin sensitivity (MetS 93.93 ± 8.54 mg/dL vs. MetS+O 69.95 ± 18.7 mg/dL, p ≤ 0.05, d = 1.65, CI = 50.32 −89.58, triglyceride reduction (MetS 492.9 ± 97.8 mg/dL vs. MetS+O 334.9 ± 98.0 mg/dL, p ≤ 0.05, d = 1.61, CI = 193.2–398.7). In addition, it promoted a reduction in systolic blood pressure (MetS 149.0 ± 9.3 mmHg vs. MetS+O 132.0 ± 11.4 mmHg, p ≤ 0.05, d = 1.63, CI = 120–140), prevented an increase in cardiac collagen (MetS 12.60 ± 2.08% vs. MetS+O 7.52 ± 0.77%, p ≤ 0.05, d = 3.24, CI = 6.56–8.49). When associated with ET, the results were similar. Thus, we conclude that O consumption combined or not with aerobic ET can have a protective effect on the cardiac tissue of rats with MetS.

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Section: Discussionmentioning

confidence: 99%