Nutritional fibrous osteodystrophy in goats

Bandarra, Paulo Mota; Pavarini, Saulo Petinatti; Santos, Adriana da Silva; Antoniassi, Nadia Aline Bobbi; Cruz, Cláudio Estêvão Farias da; Driemeier, David

doi:10.1590/s0100-736x2011001000007

Cited by 13 publications

(5 citation statements)

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“…The most frequently identified pathology within our sample was the enlargement and thickening of cranial and mandibular regions. Many of these lesions are consistent with skeletal manifestations of fibrous osteodystrophy, formed by calcium and phosphorus imbalance (Figure 2 ; Table 1 ; Bandarra et al, 2011 ; Canington & Hunt, 2016 ; Craig et al, 2016 ; Long et al, 1975 ; Lynch et al, 1999 ; Olson et al, 2015 ). Four of the pathological individuals in our sample, accessioned between 1890 and 1905, have associated accession records indicating rickets.…”

Section: Discussionmentioning

confidence: 73%

Investigating factors of metabolic bone disease in baboons (Papio spp.) using museum collections

Sadhir

Eller

Canington

et al. 2021

American Journal of Biological Anthropology

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Objectives: To assess manifestations of metabolic bone disease (MBD) and their potential environmental and phenotypic factors in captive and non-captive baboon (Papio spp.) specimens. Materials and methods: Our sample consisted of 160 baboon specimens at the Smithsonian's National Museum of Natural History accessioned from 1890 to 1971. Combining cranial indicators of MBD and the museum's historical data, we examined factors contributing to likely instances of MBD. We used binomial-family generalized linear models to assess differences in MBD frequency by environment (captive, noncaptive), specimen accession year, and skin color (light, medium, dark). Results: Indicators of MBD were most frequently observed in captive baboons, with a decrease in MBD frequency over time. Fifteen non-captive individuals showed indicators of MBD, which are the first published cases of MBD in non-captive nonhuman primates (NHPs) to our knowledge. The most common MBD indicators were bone porosity (n = 35) and bone thickening/enlargement (n = 35). Fibrous osteodystrophy was observed frequently in our sample, likely relating to nutritional deficiencies. We found no association between exposed facial skin color variation and MBD. Conclusions: Our findings are consistent with historical accounts of MBD prevalence in captive facilities, especially earlier in the 20th century. A decrease in MBD prevalence later in the 20th century likely reflects improvements in housing, diet, and veterinary care in captive settings. Causes of MBD development in non-captive baboons should be further explored, as understanding the potential health impacts that anthropogenic environments impose on NHPs is imperative as humans increasingly alter the natural world in the 21st century.

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Section: Discussionmentioning

confidence: 73%

Investigating factors of metabolic bone disease in baboons (Papio spp.) using museum collections

Sadhir

Eller

Canington

et al. 2021

American Journal of Biological Anthropology

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“…In case of domestic animals primary hyperparathyroidism is rare and may be connected to parathyroid tumors or idiopathic bilateral parathyroid hyperplasia. On the other hand, secondary hyperparathyroidism occurs sporadically and attributed to nutritional imbalance in feed or chronic renal diseases (Bandarra et al, 2011). Insufficiency in dietary calcium or excessive phosphorous diet considered as most common pathological causes of nutritional fibrous osteodystrophy.…”

Section: Introductionmentioning

confidence: 99%

“…The major clinical features of FOD encompass bone deformities and enlargements, and locomotion or postural disturbs. The disease is more frequently observed in horses (Ospina et al, 2014) and sporadically described in goats, rabbits and other mammals however, lesions tend to be rare in sheep and cattle (Bandarra et al, 2011). All breeds and ages of goats are susceptible after weaning .…”

Section: Introductionmentioning

confidence: 99%

Clinical case report on nutritional dystrophy in goats at S. A. Quadary Veterinary Teaching Hospital, CVASU, Chittagong

Akter

Kamal²,

Islam

et al. 2019

Bangladesh Journal of Veterinary Medicine

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Background: Nutritional fibrous osteodystrophy may be developed due to dietary deficiency of calcium or dietary excess of phosphorus. Fibrous osteodystrophy (FOD) provokes hyperostotic distortion of cancellous bones, conjunctive tissue proliferation, and poor mineralization of bone. The objectives of this study were to report the clinical characteristics and therapeutic management of FOD in goats. Materials and methods: Four out of 8 Jamnapari goats developed fibrous osteodystrophy in a small scale intensive household farm in Chittagong. The age range of the affected goats was 4-5 months. The feeding history of goats was primarily wheat bran, gram and pea husk. Blood sample from all affected and non-affected animals and feed sample from household farm were collected for laboratory analysis. Fibrous Osteo-dystrophy was primarily diagnosed by observing clinical signs of mandibular and maxillary enlargement, pain on pressure at the enlarged bone, protruded tongue and dyspnea which was then confirmed by high level of phosphorus in serum evaluation. Results: The calcium and phosphorus contents in the sampled gram, pea husk and bran were 0.5%, 0.3% and 0.5%, and 0.71%, 0.49% and 0.61%, respectively. Most of the affected animals had increased serum levels of phosphorus, glucose and alkaline phosphatase and decreased level of calcium. Based on the clinical findings and the laboratory report, the cases were diagnosed as fibrous osteodystrophy due to nutritional imbalance in diet. The owner was advised strictly to stop providing any bran to animals (affected and healthy). Affected animals were additionally treated with calcium preparation vitamin ADE, ketoprofen, protein, and penicillin-streptomycin combination. Conclusion: Treatment of fibrous osteodystrophy required a long time recovery along with balanced ration. A combined therapy of calcium and vitamin D and protein preparation is effective for treatment along with adequate green grass and balanced rations.

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“…A osteodistrofia fibrosa é uma desordem metabólica caracterizada por reabsorção óssea extensa, proliferação de tecidos conjuntivos fibrosos e mineralização insuficiente dos tecidos ósseos. A patogênese envolve o aumento persistente dos níveis de paratormônio no plasma (Thompson 2007) e, em caprinos, está geralmente associada ao hiperparatireoidismo secundário nutricional, em que os níveis séricos de cálcio estão diminuídos, geralmente devido ao consumo de dietas hipocalcêmicas e/ou hiperfosfatêmicas (Bandarra et al 2011). Na deficiência de cobre em caprinos, também pode haver osteopenia com ou sem ocorrência de fraturas espontâneas.…”

Section: Discussionunclassified

Deficiência de fósforo em caprinos no semiárido de Pernambuco

et al. 2018

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RESUMO: O objetivo deste estudo foi avaliar os aspectos clínicos e patológicos da deficiência de fósforo em caprinos no semiárido de Pernambuco. Para isso, visitas técnicas foram realizadas em diferentes propriedades na microrregião do Sertão do Moxotó durante o período da estação seca. Realizaram-se exames clínicos, determinação da atividade sérica de cálcio total e ionizado, fosforo sérico, magnésio, razão Ca:P, proteína total, albumina, globulina e o percentual de cinzas ósseas. Biopsias ósseas da região hipocondríaca da 12 costela direita foram fixadas em solução de formalina a 10% e descalcificadas para análises histológicas. Os principais sinais clínicos observados nos caprinos com deficiência de fósforo foram aumento da fragilidade óssea além de desidratação, magreza, hipomotilidade ruminal, alopecia, pelos opacos, quebradiços e eriçados e osteofagia. As médias dos valores das cinzas ósseas e do teor de fósforo nos ossos estavam abaixo dos valores de referência e a correlação entre essas duas variáveis foi fortemente positiva (r=0,91); a redução da concentração do fósforo sérico foi acompanhada da redução da porcentagem desse mineral nas cinzas. Esse resultado é conclusivo para o diagnóstico de deficiência de fósforo. No exame microscópico dos fragmentos ósseos das costelas, verificou-se evidente aumento da atividade osteoclástica com áreas de reabsorção óssea e maior quantidade de tecido osteóide e de fibras colágenas na matriz óssea. Conclui-se que a deficiência de fósforo é uma doença frequente em caprinos criados em regime semi-extensivo no semiárido de Pernambuco e que a suplementação desse mineral é necessária na região estudada.

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Nutritional fibrous osteodystrophy in goats

Cited by 13 publications

References 10 publications

Investigating factors of metabolic bone disease in baboons (Papio spp.) using museum collections

Investigating factors of metabolic bone disease in baboons (Papio spp.) using museum collections

Clinical case report on nutritional dystrophy in goats at S. A. Quadary Veterinary Teaching Hospital, CVASU, Chittagong

Deficiência de fósforo em caprinos no semiárido de Pernambuco

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