Gastric ulcers in pigs affected with postweaning multisystemic wasting syndrome

Corrêa, Ana Grasielle Dionísio; Zlotowsk, Priscila; Barcellos, David Emílio Santos Neves de; Cruz, Cláudio Estêvão Farias da; Driemeier, David

doi:10.1590/s0100-736x2008001200007

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…However, the ulcerations and erosions were more pronounced in the glandular mucosa than in pars oesophagea. The development of these lesions in glandular mucosa might be attributed to infectious diseases such as hog cholera, salmonellosis and PCV2 infections as well as dietary hygienic practices that disrupted the normal glandular mucosal epithelium (Correa et al, 2008;Omotosho et al, 2016). Another notable lesion in stomach was diphtheritic membrane formation in the glandular mucosa which was higher among growers.…”

Section: Resultsmentioning

confidence: 99%

Occurrence and distribution of gross and microscopic gastrointestinal lesions in pigs in Northern Kerala

Elizabeth¹,

Anoopraj²,

Ajith³

et al. 2022

Journal of Veterinary and Animal Sciences

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Gastroenteritis in swine herds pose a big constraint in pig farming due to the economic losses accompanying it. The present study utilised 57 pig carcasses to assess the occurrence and distribution of various gastrointestinal lesions in pigs in Northern Kerala. Gross changes in stomach were observed in 84.21 per cent of carcasses in which mucosal congestion (61.40 per cent) was the most frequent lesion. Principal microscopic gastric lesions observed were mucosal necrosis, cellular infiltration in lamina propria, hyperplastic epithelium, hyperkeratinisation and fibrino-necrotic membrane. Gross changes in at least one region of intestine were evident in all the samples. The most common lesions in intestines were engorgement of mesenteric blood vessels (80.70 per cent) followed by catarrhal enteritis (73.68 per cent). Salient gross lesions such as mucosal ulcers were observed only in caecum and colon, diphtheritic membrane formation was observed in ileum, caecum and colon. Major histological lesions observed in intestines were mucosal necrosis (89.47 per cent) followed by cellular infiltration in lamina propria (68.42 per cent). Histologically, the major site-specific lesions observed were Brunner gland hyperplasia in duodenum, necrosis, hyperplasia, and lymphocytic depletion of Peyer’s patches in ileum, granulomatous infiltration in ileum and colon, neutrophilic colitis and goblet cell depletion in colon. The present study observed a higher incidence of gastrointestinal variations in pigs irrespective of age and further research is needed to understand the etiological factors contributing to such heavy burden of gastrointestinal lesions.

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Section: Resultsmentioning

confidence: 99%

Occurrence and distribution of gross and microscopic gastrointestinal lesions in pigs in Northern Kerala

Elizabeth¹,

Anoopraj²,

Ajith³

et al. 2022

Journal of Veterinary and Animal Sciences

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“…Meanwhile, pigs from the 10th percentile tADG had greater (P < 0.05) stomach inflammation incidence and severity compared to those from the 30th or 70th percentiles. Again, this effect again seems biologically irrelevant; it follows the same pattern of PCV2 incidence at 22 wk postweaning, and the pathogen has been clearly linked to lesions within the stomach and gastrointestinal tract (Chianini et al, 2003;Segalés et al, 2004;Corrêa et al, 2008) Another method to determine severity of pathogen load is to determine the concentration of markers of immunological or oxidative stress. An immune response results in the production of proinflammatory cytokines, the production of which requires energy and nutrients that may have otherwise been used for growth (Broussard et al, 2003;Johnson, 1997;Spurlock, 1997).…”

Section: Resultsmentioning

confidence: 99%

Poor weaning transition average daily gain in pigs is not correlated with pathological or immunological markers of enteric disease during a porcine reproductive and respiratory syndrome virus outbreak1

Jones

Madson

Main

et al. 2014

Journal of Animal Science

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Previous research suggests that enteric disease and poor gut health interact to decrease pig performance. Our objective was to determine if light birth weight pigs or those from the bottom 10th percentile of transition ADG (tADG) have a higher incidence of pathogen presence or enteric lesions than heavier or faster-growing contemporaries. A total of 1,500 pigs were weighed at birth and divided into 5 birth weight (BRW) categories: <1, 1 to 1.25, 1.26 to 1.5, 1.51 to 1.75, and >1.76 kg. At weaning, 1,054 random pigs were moved to a commercial wean-to-finish barn. Pigs were weighed individually at 0 and 3 wk postweaning. Transition ADG was calculated as the ADG between wk 0 and 3 postweaning. One pig from each of the 10th, 30th, and 70th percentiles of tADG was used to create 1 set of 3 pigs with the same litter size and from the same parity sow. Forty pigs from each of the 3 tADG percentiles were matched for sex, litter size, and sow parity but not BRW to create 20 matched sets of 60 pigs. This allowed for the main effects of BRW and tADG to be studied as a 5 × 3 factorial design. At 3 and 22 wk postweaning, pigs were euthanized for organ system tissue evaluation. Lung, lymph node, and digesta were analyzed for presence of pathogens and for severity of microscopic lesions (0 = not present, 1 = present, with slight erosion, 2 = present, with moderate erosion, and 3 = present and severe erosion). Data were analyzed using PROC GENMOD and GLIMMIX, where pig served as the experimental unit. The fixed effects were BRW and tADG and the random effects were pen and set. There were no BRW × tADG interactions (P = 0.16). There was no correlation (P = 0.12) between tADG and pathogen presence at either 3 or 22 wk postweaning. Incidence and severity of microscopic lesions in the large intestine at 3 wk postweaning decreased linearly with increasing tADG (P = 0.01). Lesion incidence and severity were also affected (P < 0.04) by tADG at 22 wk postweaning, with greater stomach incidence in the 10th percentile. Birth weight affected (P = 0.02) haemolytic Escherichia coli and Salmonella spp. B (includes Salmonella typhimurium) isolation at 3 wk postweaning as well as Brachyspira spp. isolation at 22 wk postweaning (P = 0.05) but in mixed directions. There were no effects (P = 0.21) of BRW or tADG on serum or ileum mucosa immune markers. In summary, it is apparent from this research that neither BRW nor tADG are likely causes of pathogen or lesion incidence.

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“…Meanwhile, Pigs from the 10 th percentile tADG had greater (P < 0.05) stomach inflammation incidence and severity compared to those from the 30 th or 70 th percentiles. Again, this effect again seems biologically irrelevant, it follows the same pattern of PCV2 incidence at 22-weeks post-weaning, and the pathogen has been clearly linked to lesions within the stomach and gastrointestinal tract (Chianini et al, 2003;Segalés et al, 2004;Corrêa et al, 2008) Another method to determine severity of pathogen load is to determine the concentration of immune markers, such as immunoglobulins, cytokines, chemokines, and glutathione. An immune response results in the production of pro-inflammatory cytokines, the production of which require energy and nutrients that may have otherwise been used for growth (Broussard et al, 2003;.…”

Section: Resultsmentioning

confidence: 99%

Characterizing the Fallback Pig

Jones

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Appreciation is like looking through a wide-angle lens that lets you see the entire forest, not just the one tree limb you walked upon.-Doc Childre and Sara Paddision This dissertation is the final product of innumerable sacrifices made by others to help me succeed. First, I express my deep gratitude to Dr. John F. Patience, my major professor, mentor, and friend. You inspire me to become better each day. I also appreciate my Ph.D.

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Gastric ulcers in pigs affected with postweaning multisystemic wasting syndrome

Cited by 7 publications

References 21 publications

Occurrence and distribution of gross and microscopic gastrointestinal lesions in pigs in Northern Kerala

Occurrence and distribution of gross and microscopic gastrointestinal lesions in pigs in Northern Kerala

Poor weaning transition average daily gain in pigs is not correlated with pathological or immunological markers of enteric disease during a porcine reproductive and respiratory syndrome virus outbreak1

Characterizing the Fallback Pig

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