Introduction:Infertility is a complex disease experienced by 13-17% of couples that can involve different dimensions of women's health, not only from an underlying organic and biological point of view, but also from their sexual health. Objectives: The aim of this systematic review and meta-analysis was to evaluate infertility's impact on female sexuality. Methods: A systematic review and meta-analysis were conducted. A literature search was done for publications from 1 January 2012 to 31 December 2022 via the databases PubMed, EBSCO (MEDLINE and Health Policy Reference Center) and Websci, databases, which assess female sexual function based on the Female Sexual Function Index (FSFI) in adult women between 18 and 49 years old. Heterogeneity was estimated using I 2. The risk of bias in the selected studies was assessed using the Newcastle-Otawa Quality Assessment Scale (NOS) adapted for case-control and cross-sectional studies. Results: A total of 8 studies were included. The results indicated an association between greater sexual dysfunction and infertility in women (WMD = 2.22, 95% CI = 3.57 to 0.87, p<0.001), and high heterogeneity was observed between studies (I2= 97%, p<0.00001). The study was complemented with a meta-analysis of the individual FSFI domains, and it was observed that infertile women had significantly lower scores in all domains. Conclusion: Our review showed that infertility has a negative impact on female sexual health. These findings may help professionals in the field to deal with female sexual and reproductive health, from diagnosis to therapy, thus benefiting the couple's sexual function.