Contribuição do hiperandrogenismo para o desenvolvimento de síndrome metabólica em mulheres obesas com síndrome dos ovários policísticos

Rehme, Marta Francis Benevides; Pontes, Ana Gabriela; Corrente, José Eduardo; Franco, J.G.; Pontes, Anaglória

doi:10.1590/s0100-72032013001200006

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…On the other hand, patients with the non-hyperandrogenic PCOS phenotype (normal FGI) present as a metabolically similar group to patients without PCOS. 14 Patients with PCOS and hirsutism have been reported to have an increased risk of MS. 8 9 10 16 The progressive accumulation of fat, mainly in the abdominal region, is characterized by an increase in insulin resistance. 13 LAP reflects both the deposition of visceral fat and the increase of lipolytic activity within adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Hirsute carriers of PCOS have a 3-fold risk of developing metabolic syndrome (MS) compared with those without hirsutism. 8 9 MS occurs in ~43% of PCOS carriers, causing up to a 7-fold elevation of cardiovascular risk. 8 9 10…”

Section: Introductionmentioning

confidence: 99%

“…8 9 MS occurs in ~43% of PCOS carriers, causing up to a 7-fold elevation of cardiovascular risk. 8 9 10…”

Section: Introductionmentioning

confidence: 99%

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Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

Oliveira

Rezende²,

Faria³

et al. 2016

Rev Bras Ginecol Obstet

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Objective Polycystic ovary syndrome (PCOS) is the most common endocrine metabolic disorder in women between menarche and menopause. Clinical hyperandrogenism is the most important diagnostic criterion of the syndrome, which manifests as hirsutism in 70% of cases. Hirsute carriers of PCOS have high cardiovascular risk. Lipid accumulation product (LAP) is an index for the evaluation of lipid accumulation in adults and the prediction of cardiovascular risk. The aim of this study was to evaluate the association between LAP and hirsutism in women with PCOS. Methods This was a cross-sectional observational study of a secondary database, which included 263 patients who had visited the Hyperandrogenism Outpatient Clinic from November 2009 to July 2014. The exclusion criteria were patients without Ferriman-Gallwey index (FGI) and/or LAP data. We used the Rotterdam criteria for the diagnosis of PCOS. All patients underwent medical assessment followed by measurement and recording of anthropometric data and the laboratory tests for measurement of the following: thyroid-stimulating hormone, follicle-stimulating hormone, prolactin, total testosterone, sex hormone binding globulin, 17-α-hydroxyprogesterone (follicular phase), glycohemoglobin A1c, and basal insulin. In addition, the subjects underwent lipid profiling and oral glucose tolerance tests. Other laboratory measurements were determined according to clinical criteria. LAP and the homeostatic model assessment index (HOMA-IR) were calculated using the data obtained. We divided patients into two groups: the PCOS group with normal LAP (< 34.5) and the PCOS group with altered LAP (> 34.5) to compare the occurrence of hirsutism. For statistical analysis, we used SPSS Statistics for Windows® and Microsoft Excel programs, with descriptive (frequencies, percentages, means, and standard deviations) and comparative analyses (Student's t-test and Chi-square test). We considered relations significant when the p-value was 0.05. Results LAP was high in most patients (n ¼ 177; 67.3%) and the FGI indicated that 58.5% of the patients (n ¼ 154) had hirsutism. The analysis by LAP quartiles showed a positive correlation (p ¼ 0.04) among patients with a high FGI and an upper quartile LAP (> 79.5) when compared with those with LAP < 29.0 (lower quartile). Conclusion This study demonstrated an association between high LAP and hirsutism. The FGI could represent a simple and low-cost tool to infer an increased cardiovascular risk in women with PCOS. ResumoObjetivo A síndrome dos ovários policísticos (SOP) é o distúrbio endócrino mais comum em mulheres entre a menarca e a menopausa. O hiperandrogenismo clínico é o critério diagnóstico mais importante da síndrome, que se manifesta como hirsutismo em 70% dos casos. Portadores de SOP hirsutas têm elevado risco cardiovascular. O Lipid accumulation product (LAP) é um índice para a avaliação da acumulação de lípidos nos adultos e é um preditor de risco cardiovascular. O objetivo deste estudo é avaliar a associação entre LAP e hirsutismo em por...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

Oliveira

Rezende²,

Faria³

et al. 2016

Rev Bras Ginecol Obstet

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“…This hypertrophy results in alterations both in the deposit and in the lipolytic capacity of adipocytes. The impairment of the lipolytic function of the adipose tissue may be secondary to hyperandrogenism in women with PCOS, which would lead to greater insulin resistance 18 .…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

The relationship between overweight and female infertility

Costa¹,

Andrade²,

Soares³

et al. 2021

Rev Cienc Saude

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Excessive weight seems to negatively influence fertility, and as it is a modifiable factor, understanding this relationship can contribute to infertility treatment. Adipose tissue is responsible for releasing several hormones and cytokines related to the reproductive system, such as leptin, TNF-a, and Interleukin-6, substances that can negatively impact female fertility. Additionally, a woman's diet and lifestyle can influence body weight and fertility. Food consumption, characterized by a high intake of foods with high energy density, high levels of sugar, saturated fat, and poor nutrients, as well as physical inactivity, can favor excessive weight. Thus, losing body weight obtained through a healthy diet associated with physical activity may restore fertility in overweight women.

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“…Palabras claves: síndrome de ovario poliquístico; hiperandrogenismo; obesidad; infertilidad, Paraguay (1,2) en mujeres en edad reproductiva y se considera en la actualidad una patología familiar (3,4) . Se estima una prevalencia de 4 a 8% (5)(6)(7)(8) , mientras que otras literaturas lo elevan hasta el 10% e incluso 15% (6,9,10) . Se reporta en un 45,4% entre los 20 y 30 años de edad (11)(12)(13)(14)(15) .…”

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Características clínicas y epidemiológicas del Síndrome de Ovario Poliquístico en un Hospital de referencia de Paraguay

Giménez-Osorio

Ríos-González

2020

Rev. cient. cienc. salud

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Contribuição do hiperandrogenismo para o desenvolvimento de síndrome metabólica em mulheres obesas com síndrome dos ovários policísticos

Abstract: Obese women with PCOS have a higher frequency of metabolic syndrome than non-PCOS obese women, and hyperandrogenism does not contribute to the development of metabolic syndrome in this group of women.

Cited by 7 publications

References 36 publications

Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

The relationship between overweight and female infertility

Características clínicas y epidemiológicas del Síndrome de Ovario Poliquístico en un Hospital de referencia de Paraguay

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