Prevalência de Chlamydia trachomatis e fatores de risco associados à infecção detectada em amostra endocervical

Garcês, Alzira Xavier; Martínez, Ana Maria Barral de; Gonçalves, Carla Vitola; Germano, Fabiana Nunes; Barral, Maria Fernanda Martínez; Vieira, Valdimara Correia

doi:10.1590/s0100-72032013000800008

Cited by 12 publications

(14 citation statements)

References 13 publications

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“…Another important study carried out by Neves et al (2016) on asymptomatic women aged 14-25 years who used public health services in Manaus showed a prevalence of 13.1% for CT infections, whereas in women aged 20-25 years this prevalence was 10.8%, as determined by the Digene Hybrid Capture II Test (HCII CT-ID). Our results corroborate the prevalence range found in the rest of Brazil (9.1-14.3%) (de Paula et al, 2007;Oliveira et al, 2009;Benzaken et al, 2010;Piazzetta et al, 2011;Garcês et al, 2013). CT infection is asymptomatic in almost all women and, if left untreated, can progress to complications such as ectopic pregnancy, pelvic inflammatory disease (PID), and tubal infertility (Golijow et al, 2005).…”

Section: Discussionsupporting

confidence: 89%

Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology

Costa-Lira¹,

Jacinto²,

Silva³

et al. 2017

Genet. Mol. Res.

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Sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. We investigated the prevalence of human papillomavirus (HPV), Chlamydia trachomatis (CT), and Trichomonas vaginalis (TV), and accessed the diversity of HPV in women with normal and abnormal cytology in Manaus, Brazil. We used polymerase chain reaction and HPV genotyping by direct sequencing. The chi-square test was used to calculate the absolute and relative frequencies of the categorical variables, and Fisher's test was used when P < 0.05. The level of significance was set at 5%. All statistical analyses were performed using R 2.9.0. There were statistically significant differences in age (P = 0.0395), education level (P = 0.0131), sexual partners (P = 0.0211), condom use (P = 0.0039), marital status (P < 0.0001), and pregnancy (P = 0.0003) between the normal and abnormal groups. HPV DNA was found in 36.56 and 93.88% of subjects in the normal and abnormal groups, respectively. A total of 19 genotypes were detected; HPV16 was the most common, followed by HPV58. The percentages of TV and CT DNA were 18.04 and 9.02% in the normal group, respectively. The percentages of HPV/TV and HPV/CT coinfection were 12.5% each in women with normal cytology. These findings improve our understanding of HPV, CT, and TV, and the distribution of HPV types, which may be relevant to vaccination strategies for protecting women from the north of Brazil from cervical cancers and precancerous lesions.

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Section: Discussionsupporting

confidence: 89%

Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology

Costa-Lira¹,

Jacinto²,

Silva³

et al. 2017

Genet. Mol. Res.

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“…The global prevalence of chlamydial infection (11%) was similar to that found in other studies performed in Brazil under similar conditions, reflecting a national reality [20]. In 2008, Jalil et al performed a wide-ranging, multicentric study in the capitals of six Brazilian states.…”

Section: Discussionsupporting

confidence: 78%

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Brasiliense

Borges

Ferreira

2016

J Infect Dev Ctries

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Introduction: Genital Chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in women, and undetected cases of the disease are highly associated with long-term complications. Despite the high prevalence of infections in Brazil, very little is known about the distribution of C. trachomatis genovars. In this study, we determined the prevalence and genotypes of C. trachomatis in women treated at a public hospital in the Brazilian city of Belém, the capital of the state of Pará. Methodology: A total of 154 women were tested for chlamydial infection by PCR using specific primers for the C. trachomatis cryptic plasmid. Genotyping of positive samples was performed by sequencing the ompA gene and conducting further phylogenetic analysis. Results: Out of the 154 samples, 17 were found to be positive using C. trachomatis cryptic plasmid PCR. The overall prevalence of C. trachomatis infection was 11%, with the highest prevalence observed in women between 16 and 20 years of age. Five genotypes were found to be associated with endocervical infection. Genotype F was most frequently found (37.5%), followed by genotypes J (25%), E (25%), I (6.25%), and D (6.25%). Conclusions: This study emphasizes the relevance of C. trachomatis infection in the young female population of the Brazilian Amazon region. It also demonstrates the diversity of genotypes involved in genital infection in this population.

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“…A prevalência da infecção não difere significativamente das encontradas em outros estudos do Brasil, os quais foram realizados em populações femininas urbanas, com variados graus de instrução, como nos estados do Rio Grande do Norte (10,9%) 13 , Goiás (9,6%) 14 , Paraná (12,7%) 17 e Rio Grande do Sul (11,0%) 15 . Apenas nos estados da Bahia (31,0%) 18 e de Pernambuco (23,8%) 16 foram registradas prevalências maiores, porém com tamanho amostral inferior ao utilizado neste estudo.…”

Section: Discussionunclassified

“…No Brasil, a prevalência de infecções por C. trachomatis varia entre 4,3% e 31,0%, conforme estudos de base populacional/comunitária de grandes centros urbanos e estudos de base clínica, realizados com participantes frequentadoras de ambulatórios e clínicas ginecológicas 10,11,12,13,14,15,16,17,18,19 . Nas comunidades amazônicas, há escassez de conhecimento sobre a epidemiologia da infecção endocervical por C. trachomatis, o que impossibilita a criação de diretrizes que estabeleçam o rastreio e controle dessa infecção.…”

Section: Introductionunclassified

Prevalência da infecção endocervical de Chlamydia trachomatis em universitárias do estado do Pará, Região Amazônica, Brasil

Santos

Ulian

Trindade

et al. 2017

Revista Pan-Amazônica de Saúde

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RESUMOOBJETIVOS: Descrever a prevalência e os fatores associados à infecção endocervical por Chlamydia trachomatis em estudantes de uma universidade da capital e de três de seus campi do interior do estado do Pará, Amazônia, Brasil. MATERIAIS E MÉTODOS: Estudo transversal, com mulheres de idade igual ou superior a 18 anos, que realizaram o preventivo do câncer do colo uterino, de setembro de 2010 a outubro de 2014. O DNA da secreção cérvico-vaginal foi extraído pelo método fenol-clorofórmio e submetido à amplificação dos genes da β-globina humana e ompA de C. trachomatis por reação em cadeia da polimerase. Foram utilizados os testes de Mann-Whitney, estimação da proporção e odds ratio para análises estatísticas. O p ≤ 0,05 foi considerado estatisticamente significativo para um intervalo de confiança (IC) de 95%. RESULTADOS: A prevalência de C. trachomatis foi de 11,9% [54/454 (IC 95% 8,9-14,9)]. A infecção foi identificada em 10,4% [36/345 (IC 95% 7,2-13,7)] das estudantes da Capital e em 16,5% [18/109 (IC 95% 10,3-24,6)] das estudantes dos campi do interior (p = 0,12), sendo de 7,1% (2/28) no Interior 1, 22,2% (6/27) no Interior 2 e 18,5% (10/54) no Interior 3. Não foi observada associação entre as variáveis investigadas e a infecção endocervical por C. trachomatis. CONCLUSÃO: A prevalência da infecção por C. trachomatis entre as universitárias se assemelhou à média encontrada no Brasil e não se mostrou associada às condições sociodemográficas e comportamentais das universitárias investigadas. ARTIGO ORIGINAL | ORIGINAL ARTICLEABSTRACT OBJECTIVES: To describe the prevalence and factors associated with endocervical infection by Chlamydia trachomatis in students from a university in the capital and three campuses in inland towns of Pará State, Amazon, Brazil. MATERIALS AND METHODS: A cross-sectional study with women aged 18 years or older who underwent cervical cancer prevention from September 2010 to October 2014. DNA from cervicovaginal secretion was extracted using the phenol-chloroform method and subjected to the amplification of the human β-globin and ompA genes of C. trachomatis by polymerase chain reaction. Mann-Whitney tests, proportion estimation, and odds ratio were used for statistical analysis. The p ≤ 0.05 was considered statistically significant for a confidence interval (CI) of 95%. RESULTS: The prevalence of C. trachomatis was 11.9% ]. Infection was identified in 10.4% [36/345 (95% CI 7.2-13.7)] of the students in the Capital and in 16.5% ) of students from the campuses in the inland towns (p = 0.12), with 7.1% (2/28) in the Town 1, 22.2% (6/27) in the Town 2, and 18.5% (10/54) in the Town 3. No association between the investigated variables and the endocervical infection by C. trachomatis was observed. CONCLUSION: The prevalence of C. trachomatis infection among those university students was similar to the average found in Brazil and was not associated with the sociodemographic and behavioral conditions of the university students investigated.

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Prevalência de Chlamydia trachomatis e fatores de risco associados à infecção detectada em amostra endocervical

Abstract: The prevalence of C. trachomatis in endocervical specimens by PCR was 11%. The factors associated with a higher infection by C. trachomatis were lower education and being HIV positive.

Cited by 12 publications

References 13 publications

Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology

Prevalence of human papillomavirus, Chlamydia trachomatis, and Trichomonas vaginalis infections in Amazonian women with normal and abnormal cytology

Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Prevalência da infecção endocervical de Chlamydia trachomatis em universitárias do estado do Pará, Região Amazônica, Brasil

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