Taxa de infecção e sorotipos de Streptococcus agalactiae em amostras de recém-nascidos infectados na cidade de Campinas (SP), Brasil

Fiolo, K.; Zanardi, Cibele Esteves; Salvadego, Marizete; Bertuzzo, Carmen Sílvia; Amaral, Eliana; Calil, Roseli; Levy, Carlos Emílio

doi:10.1590/s0100-72032012001200003

Cited by 10 publications

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References 35 publications

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“…One hundred thirty-five articles (reporting data from 57 countries) met our inclusion criteria (search strategy of study selection in Figure 2 ). Of these, 90 reported incidence [ 22–96 ], (EOGBS: 74 studies; LOGBS: 33 studies), 64 reported CFR [ 22–27 , 30 , 34 , 37 , 38 , 41–43 , 46 , 49–57 , 59 , 61 , 63 , 68 , 70 , 71 , 73–75 , 78–81 , 84 , 89 , 90 , 92 , 95–111 ], and 45 reported serotype data [ 22–25 , 31 , 42 , 47 , 50 , 55 , 61 , 63 , 66 , 70 , 73 , 78 , 81 , 84 , 112–138 ]. (The full list of articles included in this review is available in Supplementary Table 3.)…”

Section: Resultsmentioning

confidence: 99%

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Madrid

Seale

Kohli-Lynch

et al. 2017

Clinical Infectious Diseases

306

304

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BackgroundGroup B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates.MethodsWe conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0–89 days. We conducted random-effects meta-analyses of incidence, case fatality risk (CFR), and serotype prevalence.ResultsWe identified 135 studies with data on incidence (n = 90), CFR (n = 64), or serotype (n = 45). The pooled incidence of invasive GBS disease in infants was 0.49 per 1000 live births (95% confidence interval [CI], .43–.56), and was highest in Africa (1.12) and lowest in Asia (0.30). Early-onset disease incidence was 0.41 (95% CI, .36–.47); late-onset disease incidence was 0.26 (95% CI, .21–.30). CFR was 8.4% (95% CI, 6.6%–10.2%). Serotype III (61.5%) dominated, with 97% of cases caused by serotypes Ia, Ib, II, III, and V.ConclusionsThe incidence of infant GBS disease remains high in some regions, particularly Africa. We likely underestimated incidence in some contexts, due to limitations in case ascertainment and specimen collection and processing. Burden in Asia requires further investigation.

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Section: Resultsmentioning

confidence: 99%

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Madrid

Seale

Kohli-Lynch

et al. 2017

Clinical Infectious Diseases

306

304

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“…Overall incidence of neonatal infections was 1.34 per 1000 livebirths which is 2.5 times higher than the estimated global incidence and twice higher the incidence reported for the Americas (0.67 per 1000 livebirths) [7]. Data reported from Latin América are variable and fluctuate between 0.3-1.15 × 1000 livebirths, with mortality rates ranging from 20 to 60% [5, 9, 22–27]. Neonatal incidence reported here is lower than previous reports by Bajaras et al in Colombia [23] (neonatal incidence: 1.8 per 1000 livebirths) and similar to that reported from Brazil by Miura et al (1.15 per 1000 livebirths 95% CI: 0.7-1.9) [24], possibly due to similar hospital characteristics.…”

Section: Discussionmentioning

confidence: 99%

Emerging trends in invasive and noninvasive isolates of Streptococcus agalactiaein a Latin American hospital: a 17-year study

et al. 2014

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BackgroundStreptococcus agalactiae or group B Streptococcus (GBS) has been recognized as a lethal pathogen in neonates worldwide. S. agalactiae infections also severely affect pregnant women and immunosuppressed adults with substantial attributable morbidity and mortality. However, in Latin America, studies on the epidemiology and behaviour of S. agalactiae infections remain limited.MethodsTo better understand the behaviour of S. agalactiae infections in our region, we conducted a retrospective study to phenotypically describe S. agalactiae isolates collected in one of the largest hospitals in Colombia at two time periods: 1994–2001 and 2004–2012. The isolates were identified by biochemical analysis and tested for antimicrobial susceptibility.ResultsIn 1994–2001 a total of 201 S. agalactiae isolates were found in urine 38.3%, vaginal exudates 27.8%, soft tissue 12.9%, and blood 8.5%. Susceptibility to ampicillin or penicillin was 94% whereas resistance to erythromycin and clindamycin were 2.8% and 5.2% respectively. In total 46 culture-positive cases of invasive infections were reported, 11 (24%) in neonates and 35 (76%) in adults. In 2004–2012 a total of 671 isolates were found in urine 47.8%, vaginal exudates 32.6%, soft tissue 2.7% and blood 9%. Susceptibility rates to ampicillin and penicillin were 98% whereas resistance to erythromycin and clindamycin were 12.5% and 9.4%. A total of 95 severe infections were reported: 12 (12.6%) were in neonates, 5 (5.3%) in children and 78 (82.1%) in adults. Over the 17-year study period the averaged prevalence of invasive S. agalactiae isolates was 17.4%. The estimated incidence for neonatal infections was 1.34 per 1000 livebirths (0.99 × 1000 livebirths for early- onset disease and 0.35 × 1000 livebirths for late- onset disease) whereas for non-pregnant adults the estimated incidence was 0.75 × 1000 admissions.ConclusionsA remarkable increase in bloodstream infections in immunosuppressed adults and a shift to early neonatal S. agalactiae infections were seen over time. We also found an increase in S. agalactiae resistance to erythromycin and clindamycin during the study period, and the emergence of penicillin-nonsusceptible isolates. Our findings are consistent with the global trends described elsewhere, reinforcing the need for S. agalactiae control measures in our region.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2334-14-428) contains supplementary material, which is available to authorized users.

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“…Os GBS diferenciam-se em dez sorotipos distintos relacionados aos determinantes antigênicos da superfície celular, sendo classificados como: Ia, Ib, II, III, IV, V, VI, VII, VIII e IX. Os dez sorotipos capsulares se distinguem de acordo com a variação da virulência e de antígenos, os quais são detectados por imunodifusão ou PCR (FIOLO et al, 2011;. A identificação dos sorotipos é crítica para estudos clínicos e epidemiológicos.…”

Section: Sorotipo Capsular Do Streptococcus Do Grupo Bunclassified

Polissacarídeo capsular do <i>Streptococcus agalactiae<i> como antígeno vacinal: desenvolvimento de um modelo vacinal para mucosas com Nanopartícula de quitosana

Hacker¹

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E um homem disse: "Fala-nos do conhecimento de si próprio." E ele respondeu, dizendo: "Vosso coração conhece em silêncio os segredos dos dias e das noites;Mas vossos ouvidos anseiam por ouvir o que vosso coração sabe. Desejais conhecer em palavras aquilo que sempre conhecestes em pensamento.Quereis tocar com os dedos o corpo nu de vossos sonhos. E é bom que o desejeis.A nascente secreta de vossa alma precisa brotar e correr, murmurando para o mar; E o tesouro de vossas profundezas ilimitadas precisa revelar-se a vossos olhos. Mas não useis balanças para pesar vossos tesouros desconhecidos; E não procureis explorar as profundidades de vosso conhecimento com uma vara ou uma sonda, Porque o Eu é um mar sem limites e sem medidas.Não digais: "encontrei a verdade." Dizei de preferência "Encontrei uma verdade." Não digais: "Encontrei o caminho da alma." Dizei de preferência:"Encontrei a alma andando em meu caminho." Porque a alma anda por todos os caminhos. A alma não marcha em linha reta nem cresce como um junco.A alma desabrocha, qual um lótus de inúmeras pétalas."Então, um professor disse: "Fala-nos do ensino." E ele respondeu, dizendo: "Homem algum poderá revelar-vos senão o que já está meio adormecido na aurora do vosso entendimento. O mestre que caminha à sombra do templo, rodeado de discípulos, não dá de sua sabedoria, mas sim de sua fé e de sua ternura. Se ele for verdadeiramente sábio, não vos convidará a entrar na mansão de seu saber, mas vos conduzirá antes ao limiar de vossa própria mente. O astrônomo poderá falar-vos de sua compreensão do espaço, mas não vos poderá dar a sua compreensão. O músico poderá cantar para vós o ritmo que existe em todo o universo, mas não vos poderá dar o ouvido que capta a melodia, nem a voz que a repete. E o versado na ciência dos números poderá falar-vos do mundo dos pesos e das medidas, mas não vos poderá levar até lá. Porque a visão de um homem não empresta suas asas a outro homem. E assim como cada um de vós se mantém isolado na consciência de Deus, assim cada um deve ter sua própria compreensão de Deus e sua própria interpretação das coisas da terra." Por Gibran Khalil Gibran "O profeta" RESUMO HACKER, S. S. Polissacarídeo capsular do Streptococcus agalactiae como antígeno vacinal: desenvolvimento de um modelo vacinal para mucosas com Nanopartícula de quitosana. 2018. 134f. Tese de Doutorado -Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, 2018. SUMMARY HACKER, S. S. Capsular polysaccharide of Streptococcus agalactiae as vaccine antigen: development of a mucosal vaccine model with chitosan nanoparticle. 2018. 134f. PhD Thesis -Faculdade de Ciências Farmacêuticas, University of São Paulo, São Paulo, 2018.Gram-positive bacteria Streptococcus agalactiae group B (GBS) is part of the normal microbiota of the human genitourinary tract, being a commensal organism of the female body. However, in pregnant women, when there are changes in the microbial composition of the vaginal canal, GBS proliferation and infection may occur. This microorganism, in its op...

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Taxa de infecção e sorotipos de Streptococcus agalactiae em amostras de recém-nascidos infectados na cidade de Campinas (SP), Brasil

Cited by 10 publications

References 35 publications

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses

Emerging trends in invasive and noninvasive isolates of Streptococcus agalactiaein a Latin American hospital: a 17-year study

Polissacarídeo capsular do <i>Streptococcus agalactiae<i> como antígeno vacinal: desenvolvimento de um modelo vacinal para mucosas com Nanopartícula de quitosana

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