Efeitos da hiperprolactinemia sobre o útero de camundongos no proestro

Abstract

Data have shown that hyperprolactinemia induced by metoclopramide determines endometrial proliferation and interferes with the ovarian function, mainly in the progesterone production.

Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle

“…We also observed a significant decrease in progesterone levels coexisted with PRL serum elevation. Overall, these disturbances may have deleterious effects on ovarian function,7 endometrial tissue,9 and embryo implantation 8. Finally, hyperprolactinemia caused by metoclopramide in mice is due to an increase in the number and activity of lactotrophs and these alterations seem to be independent of the cycle phase.…”

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

“…On the last day, one hour after drug administration, the mice were sacrificed, except for those not in proestrus. These continued to receive the drugs until they entered that phase 1 .…”

“…De fato nosso trabalho identificou grande expressão dessas isoformas nesse tecido, o que complementaria a explicação das modificações morfológicas encontrada nos trabalhos anteriores Panzam et al, 2006;Gomes et al, 2009 O PRLR uterino tem sido alvo de estudo nas duas últimas décadas, mas pouco se sabe sobre sua biologia em animais submetidos à hiperprolactinemia (Harbaum et al, 2010). Nosso estudo aponta que o tratamento com metoclopramida pode alterar a expressão dos receptores PRLR-S3 e PRLR-L no útero.…”

“…Hyperprolactinemia is characterized by persistently high prolactin (PRL) levels in the blood, and it is the most common endocrine disorder of pituitary hypersecretion on the hypothalamic-pituitary axis 1,2 .…”